Externally-used traditional Chinese medicine for treating hypertrophic scar and preparation method thereof
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A technology for hypertrophic scars and traditional Chinese medicine, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of complex composition of prescriptions and lack of pharmacology and pharmacy research, and achieve wide sources of raw materials and prescriptions. Strict compatibility, effective and effective effect
Inactive Publication Date: 2012-06-27
HUAZHONG UNIV OF SCI & TECH
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[0004] In the traditional Chinese medicine of the motherland, the prevention and treatment of hypertrophic scars are very rich in content, forming a unique theoretical system and accumulating valuable clinical experience; There is a lack of necessary pharmacology and pharmacy research, and the efficacy needs further verification
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Embodiment 1
[0040] Embodiment 1. prepares ointment
[0041] Take 44g of Scutellaria chinensis, 88g of safflower, and 132g of comfrey, add 8 times the amount of 80% ethanol, reflux and extract three times, each time for 2 hours, combine the extracts, filter, and concentrate the filtrate to a relative density of 1.15-1.20 (60°C) Clear ointment; add 80g of stearyl alcohol, 20g of glyceryl monostearate, 602g of Span-602g, 100g of liquid paraffin, 5g of simethicone, heat (85°C) to dissolve, stir evenly for later use; additionally take 10g of triethanolamine, glycerin 150g, 0.12g of propyl p-hydroxybenzoate, 0.24g of ethylparaben, and 1.5g of sodium lauryl sulfate were heated (85°C) to melt, mixed with the above clear paste, added water to 1000g, and stirred evenly to obtain this product Invention of the "scar removing" ointment.
Embodiment 2
[0042] Embodiment 2. prepare liniment
[0043] Take 15g of Scutellaria chinensis, 30g of safflower, and 60g of comfrey, crush them into coarse powder, add 500ml of 70% ethanol to seal, soak for 20 days, shake once every 2 days; filter, add 70% ethanol to 500ml from the filter , to get the "Xiaoscar" liniment of the present invention.
Embodiment 3
[0044] Example 3. Preparation of tincture
[0045] Get Sicao 20g, Flos Carthami 30g, Comfrey 40g, be ground into coarse powder, mix, according to the percolation method (2010 edition People's Republic of China Pharmacopoeia one appendix appendix 10) under extractum and extractum item, use 80 % ethanol as a solvent, slowly percolate after soaking for 48 hours, collect the percolation liquid, adjust it to 400ml with 80% ethanol, filter, and obtain the "Xiaoscar" tincture of the present invention.
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Abstract
The invention provides an externally-used traditional Chinese medicine for treating hypertrophic scar, which comprises the following raw materials in parts by weight: 1-4 parts of herba siegesbeckiae, 1-8 parts of radix arnebiae and 1-8 parts of flos carthami. The externally-used traditional Chinese medicine is prepared by extracting the above raw materials with ethanol or a vegetable oil to obtain an extractive, and then adding pharmaceutically-acceptable auxiliary materials by a conventional method. The preparation method of the externally-used traditional Chinese medicine, comprising the extraction and preparation of active ingredients, is as follows: respectively taking the ethanol and the vegetable oil as solvents; extracting the active ingredients of the raw materials; and adding matrixes of a wetting agent, a film-forming agent, a bacteriostatic agent, an emulsifier, a thickener, a gel, ointment, a film agent, a film coating agent and the like and using proper containers to prepare into the externally-used traditional Chinese medicine which can be clinically selected to apply. The externally-used traditional Chinese medicine has the advantages of strict compatibility of medicines, obvious special effect, wide sources of the raw materials, and low cost. The experiments prove that the externally-used traditional Chinese medicine can remarkably inhibit cell proliferation of skin scar and reduce scar index; meanwhile, the prepared externally-used medicine capable of being absorbed by penetrating the skins can be directly acted on the positions of pathological changes, thus the responses of the medicine is fast.
Description
technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to an externally used traditional Chinese medicine for treating hypertrophic scars and a preparation method of the externally used traditional Chinese medicine. Background technique [0002] Hyperplastic scar (HS) is a pathological phenomenon of excessive tissue repair after skin injury. Itching, tingling, pigmentation and contracture often seriously affect the appearance, function and quality of life of patients. It is the abnormal proliferation of scar fibroblasts (HypertroPhic scarfibroblast, HSF) and excessive deposition of extracellular matrix. HS is more common in people of color, and the incidence rate is about 4-16%, which is 5-15 times that of white people. Although a lot of research has been done on the pathogenesis and prevention methods of scars, so far there is no ideal result, and the current treatment methods (such as hormone injection, radiothe...
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