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Polymer hydrogel capable of in-situ crosslinking as substitute material of vitreous body

A hydrogel and polymer technology, applied in prosthetics, medical science, etc., can solve the problems of difficult removal of small molecules, harsh reaction conditions, and reduced mechanical strength, and achieve the effects of simple operation, easy preparation, and low cost

Inactive Publication Date: 2011-05-11
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As Hong, Y. etc. reported in Journal of Biomedical Materials Research, 1998, 39: 650, using vinylpyrrolidone (VP) as monomer, EGDMA, DVG, etc. Then the resulting gel is injected into the vitreous cavity as a vitreous substitute material. The material has good rheological properties before injection, but its mechanical strength decreases significantly after injection, and there are obvious macrophage phagocytosis, which is mainly due to The gel was fragmented during injection and implantation; PVA has excellent biocompatibility in theory, and PVA-like hydrogels are also considered to be ideal as artificial vitreous materials, but they are usually irradiated with gamma rays Cross-linked, not suitable for in vivo cross-linking and can only be injected after in vitro cross-linking, there is also the problem of gel fragmentation
In addition, Chirila T. et al. also proposed in Progress in Polymer Science, 1998, 23: 457 that the raw material preparation of PVA may also introduce some toxicity
In short, the previous preparation of hydrogel as a vitreous substitute material can only be implanted after in vitro cross-linking due to harsh reaction conditions or the need to add some small molecule additives, which will lead to gel fragmentation or gel formation. A series of problems such as small molecules are difficult to remove

Method used

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  • Polymer hydrogel capable of in-situ crosslinking as substitute material of vitreous body
  • Polymer hydrogel capable of in-situ crosslinking as substitute material of vitreous body
  • Polymer hydrogel capable of in-situ crosslinking as substitute material of vitreous body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1, Preparation of in situ hydrogel for vitreous cavity

[0029] Polymer preparation of component A:

[0030] Use hydroxyl-terminated PEG (number-average molecular weight of 6000, provided by Sigma-Aldrich, item number 81260) (please provide the company name and catalog number that sells the product) as raw material, refer to literature (Lee, Y., etc., Biomacromolecules, 2005, 6:24) to prepare the compound represented by formula I, wherein x is an integer greater than 100 and less than 200.

[0031]

[0032] Formula I

[0033] The specific preparation method is as follows:

[0034] Dissolve 30.0 g of hydroxy-terminated PEG (number-average molecular weight: 6000) in 500 mL of dry THF, add 4.5 mL of triethylamine and 5.7 g of p-toluenesulfonic acid chloride, react at room temperature for 24 hours, and mix the resulting product with thioacetic acid 3.5 g of potassium was refluxed at 85° C. for 4 hours, and finally the resulting product was stirred with 2M methan...

Embodiment 2

[0045] Example 2, Preparation of in situ hydrogel for vitreous cavity

[0046] Polymer preparation of component A:

[0047] Using PVA (the number average molecular weight is 31000-50000, provided by Sigma-Aldrich, product number 363138) as raw material, the compound shown in formula III is prepared according to the method of reference (Tortora, M., etc., Biomacromolecules, 2007, 8: 209), wherein , x is an integer of 700-1200.

[0048]

[0049] Formula III

[0050] The specific preparation method is as follows:

[0051] Dissolve 30.0g of PVA (number average molecular weight: 37,000) in 500mL of distilled water, heat to 80°C to dissolve completely, add 3.0g of sodium metaperiodate, and reflux the solution for 30 minutes. After cooling to room temperature, add 3.5g barium chloride, filter out insoluble matter, add 45.0g cysteine ​​dissolved in 100mL pH=4.5 buffer solution to the solution, heat to reflux for 1 hour, cool to room temperature, and continue stirring After 30 m...

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Abstract

The invention discloses a hydrogel vitreous body substitute material. The vitreous body substitute material is in-site hydrogel used for the cavity of a vitreous body and comprises component A, component B and an aqueous solution, wherein the component A contains at least one polymer with two or more mercapto functional groups on each molecular chain, the component B contains at least one polymer with two or more vinyl sulfone functional groups on each molecular chain, the number of the mercapto functional groups in the polymer of component A and the number of the vinyl sulfone functional groups in the polymer of component B can not be 2 at the same time. The vitreous body substitute material adopts two-component design so as to greatly facilitate material storage, any component has good stability in case of independent existence, and the vitreous body substitute material can be used only by uniformly mixing the solutions of the component A and the component B and transplanting into the cavity of vitreous body.

Description

technical field [0001] The invention relates to an in-situ cross-linkable polymer hydrogel vitreous substitute material. Background technique [0002] As an important component of the eyeball, the vitreous body fills between the lens and the retina, supports the retina, and makes the retina close to the pigment epithelium. Vitreous opacity or vitreous hemorrhage caused by some ophthalmic diseases and a large number of ophthalmic surgeries require removal of the vitreous. After vitrectomy, in order to maintain the support of the retina, it needs to be filled with substitute material, that is, artificial vitreous material. [0003] In the nearly hundred years since the last century, people have tried a lot of vitreous replacement materials, including physiological saline, silicone oil or silicone resin, air and fluorinated hydrocarbon gas, etc., which are widely used in commercial use. The biggest feature of these materials is that they are easy to implant. , implantation ca...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/24A61L27/22A61L27/20A61L27/18A61L27/16
Inventor 童新明黄延宾郭宝华
Owner TSINGHUA UNIV
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