Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof
A technology for rheumatoid arthritis and arthritis, which is applied in the field of traditional Chinese medicine composition for treating rheumatoid arthritis in children and its preparation field, can solve problems such as large toxic and side effects of drugs, and achieve the effects of strong targeting, easy manufacture and pain relief.
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preparation example Construction
[0056] The preparation method of the capsule of the present invention: first make Gentiana 500g, Rehmannia glutinosa 500g, Radix Astragali 500g, Angelica 500g, Drynaria fortunei 500g, Poria cocos 500g, Psoraleae 500g, Sanqi 500g, Geranium 500g, Dipsacus 500g, Su 500g of wood, 500g of Shenjincao, 500g of Clematis, 500g of peach kernel, 500g of wood beetle, and 500g of earthworm are crushed into coarse powder, then further crushed, and passed through a 100-120-mesh sieve, so that the amount of fine powder that can pass through the sieve reaches 30%, collect the fine powder that passes through the sieve to obtain fine powder a; put the coarse powder that cannot pass through the 120 mesh sieve into a multifunctional extraction tank for extraction twice, add 5-10 times the amount of water for the first time and decoct for 1-2 hours, For the second time, add 4-8 times the amount of water and decoct for 1-2 hours, combine the two decoctions, and filter to obtain the filtrate; mix the ...
experiment example 2
[0073] Experimental example 2: Cumulative toxicity test:
[0074] Traditional Chinese medicine preparation of the present invention is taken orally honey refined pills to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 3 weeks after stopping the drug, there was no significant change in the organs of the rats. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.
experiment example 3
[0075] Experimental Example 3: Results of Acute Percutaneous Toxicity Test
[0076] The medicinal compound preparation for external use of the present invention has the effects of expelling wind and dampness, promoting blood circulation and dredging collaterals, and is used for treating rheumatism, rheumatoid arthritis and other diseases. Accordingly, the acute percutaneous toxicity test was first carried out to observe whether the drug's acute percutaneous toxicity to rats is actually non-toxic.
[0077] Test substance: the preparation ointment for external use of the present invention. Weigh 50g of the test substance and add distilled water to make a 50% paste for subsequent use.
[0078] Experimental animals: 20 SD rats were provided by the Experimental Animal Center of Shandong Provincial Academy of Traditional Chinese Medicine, male and female, weighing 180-220g, first-class animals (Yidongzi No. 08-25), and the source of feed was the same as above. Animal room environm...
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