Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof

A technology for rheumatoid arthritis and arthritis, which is applied in the field of traditional Chinese medicine composition for treating rheumatoid arthritis in children and its preparation field, can solve problems such as large toxic and side effects of drugs, and achieve the effects of strong targeting, easy manufacture and pain relief.

Active Publication Date: 2011-08-31
江西博屾医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is that there is a need for a traditional Chinese medicine preparation for the treatment of rheumatoid arthritis that relieves pain, improves swelling, prevents joint deformation, and relieves the pain of sick children. In the past, chemical medicine and Chinese patent me

Method used

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  • Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof
  • Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof
  • Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0056] The preparation method of the capsule of the present invention: first make Gentiana 500g, Rehmannia glutinosa 500g, Radix Astragali 500g, Angelica 500g, Drynaria fortunei 500g, Poria cocos 500g, Psoraleae 500g, Sanqi 500g, Geranium 500g, Dipsacus 500g, Su 500g of wood, 500g of Shenjincao, 500g of Clematis, 500g of peach kernel, 500g of wood beetle, and 500g of earthworm are crushed into coarse powder, then further crushed, and passed through a 100-120-mesh sieve, so that the amount of fine powder that can pass through the sieve reaches 30%, collect the fine powder that passes through the sieve to obtain fine powder a; put the coarse powder that cannot pass through the 120 mesh sieve into a multifunctional extraction tank for extraction twice, add 5-10 times the amount of water for the first time and decoct for 1-2 hours, For the second time, add 4-8 times the amount of water and decoct for 1-2 hours, combine the two decoctions, and filter to obtain the filtrate; mix the ...

experiment example 2

[0073] Experimental example 2: Cumulative toxicity test:

[0074] Traditional Chinese medicine preparation of the present invention is taken orally honey refined pills to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 3 weeks after stopping the drug, there was no significant change in the organs of the rats. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

experiment example 3

[0075] Experimental Example 3: Results of Acute Percutaneous Toxicity Test

[0076] The medicinal compound preparation for external use of the present invention has the effects of expelling wind and dampness, promoting blood circulation and dredging collaterals, and is used for treating rheumatism, rheumatoid arthritis and other diseases. Accordingly, the acute percutaneous toxicity test was first carried out to observe whether the drug's acute percutaneous toxicity to rats is actually non-toxic.

[0077] Test substance: the preparation ointment for external use of the present invention. Weigh 50g of the test substance and add distilled water to make a 50% paste for subsequent use.

[0078] Experimental animals: 20 SD rats were provided by the Experimental Animal Center of Shandong Provincial Academy of Traditional Chinese Medicine, male and female, weighing 180-220g, first-class animals (Yidongzi No. 08-25), and the source of feed was the same as above. Animal room environm...

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Abstract

The invention discloses a Chinese medicinal composition for treating pediatric rheumatoid arthritis. An oral preparation of the Chinese medicinal composition is prepared from large-leaved gentian, prepared rehmannia root, astragalus root, Chinese angelica, drynaria rhizome, tuckahoe, earthworm, malaytea scurfpea fruit, pseudo-ginseng, geranium nepalense, teasel root, Sappan wood, common clubmoss herb, clematidis root, peach kernel and ground beeltle; and an externally applied preparation of the Chinese medicinal composition is prepared from red-rooted salvia root, cassia twig, frank incense, myrrh, Szechuan lovage rhizome, nux vomica, beautiful sweetgum fruit, scorpion, dragon's blood, ground beetle, teasel, earthworm, safflower and vein fern rhizome. The Chinese medicinal composition disclosed by the invention has the effects of treating moist heat arthralgia spasm syndrome, replenishing the vital essence, removing heat, eliminating dampness and relaxing collaterals. The technology has the advantages of convenience for medicine administration, direct access to wound portions, strong target activity, easiness for medicine manufacture, low cost and the like. In the invention, Chinese medicinal plants with different medicinal properties are scientifically compatible with each other so that an ideal treatment effect can be obtained; and moreover, the Chinese medicinal composition is safe without any toxic or side effect, and can be used for replenishing the vital essence, removing heat, eliminating dampness, relaxing collaterals and eliminating the pain while taken orally and applied externally at the same time.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine composition for treating infantile rheumatoid arthritis and a preparation method thereof. Background technique [0002] Juvenile rheumatoid arthritis (JRA), also known as juvenile rheumatoid arthritis (JRA), is a common connective tissue disease in childhood, characterized by chronic arthritis and multi-system involvement, including joints, skin, liver, etc. , spleen, lymph nodes. Younger children often have persistent irregular fever first, and their systemic symptoms are more significant than joint symptoms. Older children or adult patients are more limited to joint symptoms. The clinical manifestations of this disease are quite different, and can be divided into different types, so there are many names: juvenile rheumatoid recurrent high fever (Wissler Fanconi syndrome), juvenile chronic art...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K36/889A61K9/70A61P19/02A61P29/00A61K35/64A61K35/62A61K35/646
Inventor 梁轶聪李佃场王漪
Owner 江西博屾医疗器械有限公司
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