Aspergillus immunodominance antigen and application thereof

An immunodominant antigen, Aspergillus technology, applied in the field of immunodiagnosis, can solve problems such as little understanding
CN102174485AInactive Publication Date: 2011-09-07NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
Publication Date
2011-09-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of immunodiagnosis and discloses an aspergillus immunodominance antigen and an application thereof. The antigen is one or more of aspergillus thioredoxin reductase, fructose-bisphosphate aldolase, actin cytoskeleton protein V1P1 and secretory dipeptidyl peptidase. The aspergillus immunodominance antigen can react with specific antibodies in the serums of the patients suffering from invasive aspergillosis strongly and can be used for preparing a diagnostic reagent of invasive aspergillosis.
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Description

technical field

[0001] The invention belongs to the field of immunodiagnosis, and relates to an aspergillus immunodominant antigen and its application. More specifically, the present invention relates to newly identified Aspergillus fumigatus antigens which strongly react with specific antibodies in the sera of patients with invasive aspergillosis. Through gene recombination technology, use prokaryotic cell expression system to obtain recombinant protein. The present invention also relates to the use of the immunodominant antigen in the serological diagnosis of invasive aspergillosis. Background technique

[0002] Invasive aspergillosis (IA) is an infectious disease and is a serious fungal infection with high mortality. In recent years, the incidence of this infection has increased significantly, and it has become an important cause of death for patients with low immune function such as blood diseases, organ transplants, bone marrow transplants, AIDS, and autoimmune diseas...

Claims

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