Method for loading hydrophobic medicament uniformly on hydrophilic polymer electrospinning nanofiber

A technology of electrospinning nanofibers and hydrophilic polymers, which is applied in the field of biomedical engineering and medicine, can solve problems such as uneven dispersion and easy aggregation into agglomerates, and achieve the effects of simple equipment, avoiding violent release, and convenient operation

Inactive Publication Date: 2011-09-14
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] But so far, such research work is mostly limited to the use of hydrophilic polymer electrospun nanofibers for loading and controlled release of hydrophilic drugs, when it is used for loading and controlled release of hydrophobic drugs or drugs with very low water solubility. , there will be problems su

Method used

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  • Method for loading hydrophobic medicament uniformly on hydrophilic polymer electrospinning nanofiber
  • Method for loading hydrophobic medicament uniformly on hydrophilic polymer electrospinning nanofiber
  • Method for loading hydrophobic medicament uniformly on hydrophilic polymer electrospinning nanofiber

Examples

Experimental program
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Effect test

Embodiment 1

[0025] (1) Preparation of Hydrophobic Drug-β Cyclodextrin Inclusion Complex

[0026] The β-cyclodextrin is heated and dissolved in water at 60°C in a water bath to form a β-cyclodextrin aqueous solution with a mass concentration of 11.85%; the hydrophobic drug ibuprofen (Ibuprofen) is dissolved in ethanol to make a mass concentration It is 8.4% drug solution; slowly drop the drug solution into the β-cyclodextrin aqueous solution (the volume ratio of the β-cyclodextrin aqueous solution and the drug solution is 4:1), keep the water bath at 60°C after the dropwise addition, and use 400r Stir at a speed of 1 / min for 3 hours, pass the resulting solution through a 0.45 μm filter nanofiber, store the filtrate at 5°C overnight, filter it with suction, and dry it in vacuum at 40°C for 24 hours to obtain a hydrophobic drug-β-cyclodextrin inclusion compound thing;

[0027] (2) dissolving the hydrophobic drug-β-cyclodextrin inclusion complex obtained in step (1) in water to prepare a sol...

Embodiment 2

[0031] (1) Preparation of Hydrophobic Drug-β Cyclodextrin Inclusion Complex

[0032] Heat and dissolve β-cyclodextrin in water at 70°C in a water bath to form an aqueous solution of β-cyclodextrin with a mass concentration of 13%; dissolve the hydrophobic drug ibuprofen in ethanol to make a mass concentration of 9% drug solution; slowly drop the drug solution into the β-cyclodextrin aqueous solution (the volume ratio of the β-cyclodextrin aqueous solution and the drug solution is 4:1), keep the 60°C water bath after the dropping, and use 300r / min Stir at a high speed for 5 hours, pass the obtained solution through a 0.45 μm filter nanofiber, store the filtrate at 10°C overnight, filter it with suction, and dry it in vacuum at 60°C for 48 hours to obtain a hydrophobic drug-β-cyclodextrin inclusion compound;

[0033] (2) dissolving the hydrophobic drug-beta cyclodextrin inclusion complex obtained in step (1) in water to form a solution with a mass concentration of 2.0%;

[0034] ...

Embodiment 3

[0037] (1) Preparation of Hydrophobic Drug-β Cyclodextrin Inclusion Complex

[0038] Heat and dissolve β-cyclodextrin in water at 50°C in a water bath to form an aqueous solution of β-cyclodextrin with a mass concentration of 7%; take the hydrophobic drug ibuprofen and dissolve it in ethanol to make a mass concentration of 7% The drug solution; the drug solution is slowly dropped into the β-cyclodextrin aqueous solution (the volume ratio of the β-cyclodextrin aqueous solution and the drug solution is 4:1), and after the drop is completed, keep the water bath at 80 ° C, and use 300r / min Stir at a high speed for 6 hours, pass the obtained solution through a 0.45 μm filter nanofiber, store the filtrate at 4°C overnight, filter it with suction, and dry it in vacuum at 50°C for 32 hours to obtain a hydrophobic drug-β-cyclodextrin inclusion compound;

[0039] (2) dissolving the hydrophobic drug-β-cyclodextrin inclusion compound obtained in step (1) in water to prepare a solution wit...

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Abstract

The invention discloses a method for loading a hydrophobic medicament uniformly on hydrophilic polymer electrospinning nanofiber. The method comprises the following steps of: (1) preparing the hydrophobic medicament-beta cyclodextrin inclusion compound; (2) dissolving the hydrophobic medicament-beta cyclodextrin inclusion compound into water to prepare solution with the mass concentration of 1.0 to 4.0 percent; (3) dissolving the hydrophilic polymer raw material into water to prepare solution with the mass concentration of 3.0 to 10.0 percent; and (4) mixing the solution uniformly to obtain electrospinning liquid, and preparing the electrospinning nanofiber by using an electrostatic spinning instrument under the conditions of the voltage of 15 to 20 kV, the spinning temperature of between 50 and 60 DEG C and the propelling speed of 0.001 to 0.003 mm/s. By the method, the hydrophobic medicament molecules are loaded in the hydrophilic polymer electrospinning nanofiber uniformly and controlled to release.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering and medicine, in particular to a method for uniformly loading hydrophobic drugs on hydrophilic polymer nanometer electrospun fibers. Background technique [0002] As a new type of drug carrier, polymer electrospun nanofibers have attracted extensive attention and interest at home and abroad in recent years. Electrospun nanofibers have a higher specific surface area, and have a high similarity to the extracellular matrix in structure, making it an obvious advantage when used as a drug carrier (a.Travis J.Sill, Horst A.von Recum.Biomaterials, 2008 , 29(13): 1989-2006.b. Lu Yao, Jiang Hongliang, Zhu Kangjie. Chinese Journal of Biomedical Engineering, 2008, 27(6): 926-932). The polymer raw materials that have been electrospun mainly include hydrophobic polylactic acid, polycaprolactone, poly(glycolide-lactide) and hydrophilic sodium alginate, chitosan, dextran, gelatin, Hyaluronic aci...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/48A61K47/32A61K47/36A61K31/192A61K31/405A61K31/573D01F9/00D01D5/00A61K47/69
Inventor 林坚涛张黎明胡剑灿邓敏敏
Owner SUN YAT SEN UNIV
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