Method for preparing bezoar soft capsules for clearing away heat and reducing fire as well as dispelling wind and relieving pain

A technology of clearing and softening capsules, which is applied in the field of preparation of traditional Chinese medicine preparations. It can solve the problems of concentration change, high extraction temperature, troublesome post-processing, etc., and achieve the effects of reducing the loss of heat-sensitive components, improving extraction efficiency, and reducing extraction temperature.

Active Publication Date: 2011-11-23
TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above method, decoction, dipping, and percolation are used to extract the active ingredients of the prescription medicinal materials. The decoction and dipping methods have long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive components, and low recovery rate of active ingredients. Disadvantages such as troublesome post-processing; percolation method has disadvantages such as long extraction time, easy volatilization loss of ethanol during percolation process, resulting in concentration change, low recovery rate of active ingredients, etc.

Method used

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  • Method for preparing bezoar soft capsules for clearing away heat and reducing fire as well as dispelling wind and relieving pain
  • Method for preparing bezoar soft capsules for clearing away heat and reducing fire as well as dispelling wind and relieving pain

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Prescription: artificial bezoar 290g, mint 4.41kg, chrysanthemum 5.88kg, nepeta panicle 2.35kg, angelica dahurica 2.35kg, chuanxiong 2.35kg, gardenia 7.35kg, coptis 2.35kg, cork 1.47kg, scutellaria baicalensis 7.35kg, rhubarb 11.77kg, Alice 7.35kg, Radix Paeoniae Rubra 2.35kg, Angelica 7.35kg, Rehmannia glutinosa 9.41kg, Campanulaceae 2.35kg, Licorice 1.47kg, Gypsum 11.77kg, Borneol 1.47kg

[0041] The preparation method comprises the following steps:

[0042] a. Extraction of Forsythia, Peppermint and Nepeta

[0043] a1. Mix the prescribed amount of forsythia, mint and nepeta, and crush it into a coarse powder for later use;

[0044] a2. The medicinal powder obtained in step a1 is placed in a multifunctional extraction tank, and the volatile oil is extracted by straight-through steam distillation, and the distilled aqueous solution is collected in another device for subsequent use;

[0045] a3. Add water equivalent to 3 times the weight of the medicinal powder ob...

Embodiment 2

[0057] Prescription: artificial bezoar 290g, mint 4.41kg, chrysanthemum 5.88kg, nepeta panicle 2.35kg, angelica dahurica 2.35kg, chuanxiong 2.35kg, gardenia 7.35kg, coptis 2.35kg, cork 1.47kg, scutellaria baicalensis 7.35kg, rhubarb 11.77kg, Alice 7.35kg, Radix Paeoniae Rubra 2.35kg, Angelica 7.35kg, Rehmannia glutinosa 9.41kg, Campanulaceae 2.35kg, Licorice 1.47kg, Gypsum 11.77kg, Borneol 1.47kg

[0058] The preparation method comprises the following steps:

[0059] a. Extraction of Forsythia, Peppermint and Nepeta

[0060] a1. Mix the prescribed amount of forsythia, mint and nepeta, and crush it into a coarse powder for later use;

[0061] a2. The medicinal powder obtained in step a1 is placed in a multifunctional extraction tank, and the volatile oil is extracted by straight-through steam distillation, and the distilled aqueous solution is collected in another device for subsequent use;

[0062] a3. Add water equivalent to 2 times the weight of the powder obtained in ...

Embodiment 3

[0074] Prescription: artificial bezoar 290g, mint 4.41kg, chrysanthemum 5.88kg, nepeta panicle 2.35kg, angelica dahurica 2.35kg, chuanxiong 2.35kg, gardenia 7.35kg, coptis 2.35kg, cork 1.47kg, scutellaria baicalensis 7.35kg, rhubarb 11.77kg, Alice 7.35kg, Radix Paeoniae Rubra 2.35kg, Angelica 7.35kg, Rehmannia glutinosa 9.41kg, Campanulaceae 2.35kg, Licorice 1.47kg, Gypsum 11.77kg, Borneol 1.47kg

[0075] The preparation method comprises the following steps:

[0076] a. Extraction of Forsythia, Peppermint and Nepeta

[0077] a1. Mix the prescribed amount of forsythia, mint and nepeta, and crush it into a coarse powder for later use;

[0078] a2. The medicinal powder obtained in step a1 is placed in a multifunctional extraction tank, and the volatile oil is extracted by straight-through steam distillation, and the distilled aqueous solution is collected in another device for subsequent use;

[0079] a3. Add water equivalent to 4 times the weight of the medicinal powder ob...

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Abstract

The invention discloses a method for preparing bezoar soft capsules for clearing away heat and reducing fire as well as dispelling wind and relieving pain. Active ingredients of prescription medicinal materials are extracted by using a membrane filter pressing cyclic extraction and separation integrated technology in place of a decoction method, an impregnation method and a percolation method. Thus, a process flow can be simplified, the production period is greatly shortened, energy consumption is reduced, environmental protection and waste residue utilization are facilitated, the using amount of ethanol serving as an extraction solvent can be reduced, and the recovery rate of the active ingredients is greatly increased.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of a traditional Chinese medicine preparation. Background technique [0002] National drug standard YBZ01492003-2009Z records: Niuhuang Shangqing Soft Capsule has the effect of clearing heat and purging fire, dispersing wind and relieving pain, and is clinically used for headache, dizziness, red eyes and tinnitus, sore throat, Mouth sores, swollen and painful gums, dry stool and other symptoms, the curative effect is definite. The prescription consists of 2.9g artificial bezoar, 44.1g mint, 58.8g chrysanthemum, 23.5g nepeta, 23.5g angelica, 23.5g chuanxiong, 73.5g gardenia, 23.5g berberine, 14.7g phellodendron, 73.5g scutellaria, 117.7g rhubarb , forsythia 73.5g, red peony 23.5g, angelica 73.5g, rehmannia 94.1g, bellflower 23.5g, licorice 14.7g, gypsum 117.7g, borneol 14.7g, a total of 19 herbs. The preparation method is to grind borneol and artificial bezoar into fine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/48A61P29/00A61P25/00A61P1/08A61P27/02A61P27/16A61P11/04A61P1/02A61P1/10A61K31/045A61K33/06A61K35/413
Inventor 冯天炯秦郁文刘世琪林榜建张晓静姜进母力房华容
Owner TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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