Preparation method of N-phenethyl-4-phenylaminopiperidine
A technology of anilinopiperidine and phenethyl, which is applied in the field of preparation of N-phenethyl-4-anilinylpiperidine, an intermediate of fentanyl, can solve the problem of harsh reaction conditions, high price and poor product quality. Stability and other issues, to achieve the effect of less by-products, low cost, and high product purity
Active Publication Date: 2011-11-23
EAST CHINA UNIV OF SCI & TECH
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Abstract
The invention relates to a method for preparing N-phenethyl-4-phenylaminopiperidine. The method comprises the main steps of carrying out hydrogenation and amination on N-phenethyl-4-piperidone (structural formula as shown in a formula (II)) and aniline (structural formula as shown in a formula (III)) in ethanol in the presence of Raney Ni at the temperature of 50-100 DEG C so as to obtain the target product. The method for preparing N-phenethyl-4-phenylaminopiperidine has the advantages of cheap and available raw material, less byproduct, good product purity, high yield, low cost and the like.
Application Domain
Organic chemistry
Technology Topic
AnilinePhotochemistry +5
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