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A kind of camphor leaf volatile oil clathrate and preparation method thereof

A technology of clathrate of volatile oil and camphor leaves, applied in the biological field of Microsporum ointment), insecticidal, analgesic and anti-inflammatory effects, which can solve the problems of unfavorable feed storage, reduced bioavailability, easy mildew, etc. To achieve the effect of improving bioavailability, improving stability and protecting drug efficacy

Inactive Publication Date: 2011-12-14
SICHUAN AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natural plant extracts are generally liquid substances that are insoluble in water. If natural plant extracts are directly added to feed as feed additives without treatment, it will not only be unfavorable for the storage of feed (very easy to mildew), transportation, but also Greatly reduce its bioavailability, limit the efficacy of the drug, and also limit the route of administration, inhibiting the further utilization of natural plant extracts

Method used

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  • A kind of camphor leaf volatile oil clathrate and preparation method thereof
  • A kind of camphor leaf volatile oil clathrate and preparation method thereof
  • A kind of camphor leaf volatile oil clathrate and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Preparation of volatile oil from camphor leaves: wash fresh camphor leaves, cut them into pieces, put them in a flask, and extract them with steam distillation in a volatile oil extraction device. Sodium sulfate drying, to obtain camphor leaf volatile oil.

[0036] Accurately weigh 4g of β-cyclodextrin, prepare a solution according to the ratio of β-cyclodextrin:water 1:20, and heat it in a water bath at 60°C until dissolved. Take another 1ml of camphor volatile oil and dissolve it with 1ml of polyethylene glycol 400, slowly drop the polyethylene glycol solution of camphor volatile oil into the aqueous solution of β-cyclodextrin at constant temperature (60°C) under stirring, and wait until all the drops are finished , and continue to stir for 3h under the condition of heat preservation. Refrigerate the formed clathrate suspension (0°C) for 24 hours, filter with suction, discard the filtrate, wash the clathrate with distilled water, drain it and dry it at low temperatur...

Embodiment 2

[0038] Accurately weigh 6g of β-cyclodextrin, prepare a solution according to the ratio of β-cyclodextrin:water 1:10, and heat it in a water bath at 50°C until dissolved. Take another 1ml of camphor volatile oil and dissolve it with 1ml of polyethylene glycol 400, and slowly drop the polyethylene glycol solution of camphor volatile oil into the β-cyclodextrin solution at a constant temperature (50°C) under stirring. After all the drops are finished, Continue to stir at constant temperature for 3h. Refrigerate the formed clathrate suspension (0°C) for 24 hours, filter with suction, discard the filtrate, wash the clathrate with distilled water, drain it and dry it at low temperature to finally obtain the clathrate. The yield of inclusion compound prepared under this condition was 90.82%, and the inclusion rate was 72.22%. Fourier transform infrared spectroscopy (FI-IR) confirmed the formation of clathrates.

Embodiment 3

[0040] Accurately weigh 8g of β-cyclodextrin, prepare a solution according to the ratio of β-cyclodextrin:water 1:15, and heat in a water bath at 40°C until dissolved. Take another 1ml of camphor volatile oil and dissolve it with 1ml of polyethylene glycol 400, and slowly drop the polyethylene glycol solution of camphor volatile oil into the β-cyclodextrin solution at constant temperature (40°C) under stirring. After all the drops are finished, Continue to stir for 3h under the condition of heat preservation. Refrigerate the formed clathrate suspension (0°C) for 24 hours, filter with suction, discard the filtrate, wash the clathrate with distilled water, drain it and dry it at low temperature to finally obtain the clathrate. The yield of clathrate prepared under this condition was 78.59%, and the inclusion rate was 80.00%. Fourier transform infrared spectroscopy (FI-IR) confirmed the formation of clathrates.

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Abstract

The invention relates to a cinnamomum longepaniculatum leaf volatile oil beta-cyclodextrin clathrate compound serving as a functional biological feed additive and a preparation method thereof. The preparation method comprises the following steps of: adding cinnamomum longepaniculatum leaf volatile oil dissolved in an organic solvent into aqueous solution containing beta-cyclodextrin, and stirring. The cinnamomum longepaniculatum leaf volatile oil beta-cyclodextrin clathrate compound has the characteristics of mild clathrate condition, simplicity of operation, easy control and high clathrate yield. The prepared clathrate compound makes the cinnamomum longepaniculatum leaf volatile oil in the solid state and convenient to mix for livestock and poultry, the medicinal effect of the volatile oil can be protected, and the palatability is improved, so the defects of irritation, volatility and the like due to the direct adoption of the volatile oil are overcome. The clathrate compound has theeffects of resisting bacteria (escherichia coli, salmonella and staphylococcus aureus), resisting fungi (trichophyton mentagrophytes, microsporum canis and microsporum gypseum), killing insect pests,easing pain and resisting inflammation, and is a good biological feed additive which is used for resisting diseases and promoting growth and avoids residue.

Description

technical field [0001] The invention relates to a functional biological feed additive oil camphor leaf volatile oil β-cyclodextrin inclusion compound and a preparation method thereof, in particular to an antibacterial (Escherichia coli, Salmonella and Staphylococcus aureus), antifungal (muscle Trichophyton, Microsporum canis and Microsporum gypsum), biological feed additive β-cyclodextrin inclusion compound with insecticidal, analgesic and anti-inflammatory effects and its preparation method. Background technique [0002] Drug feed additives play an important role in my country's livestock and poultry breeding industry because of their functions of promoting the growth of livestock and poultry and preventing diseases, improving productivity and raising economic benefits. However, with the long-term use of pharmaceutical feed additives, especially the abuse of antibiotics and chemically synthesized drugs in feed, problems such as drug resistance, drug residues, and environmen...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K47/40A61P31/00A61P33/00A61P29/00A23K1/14A61K127/00A23K20/158A23K20/163
Inventor 殷中琼魏琴贾仁勇周黎军杜永华杨华兴蒋勤久
Owner SICHUAN AGRI UNIV
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