A kind of preparation method of chitosan composite acetalized polyvinyl alcohol medical dressing

Abstract

The invention discloses a method for preparing a chitosan compound acetalized polyvinyl alcohol medical dressing. The method comprises the following steps of: dissolving chitosan in an acetic acid aqueous solution to obtain a chitosan solution; mixing polyvinyl alcohol-AH26 and polyvinyl alcohol-1799, dissolving the mixture in boiled water, and uniformly mixing the mixture with the chitosan solution to obtain chitosan / polyvinyl alcohol blended solution; mixing the polyvinyl alcohol-AH26 and polyvinyl alcohol-1799, and dissolving the mixture in boiled water, adding sodium dodecyl sulfate, formaldehyde solution, sodium bicarbonate and hydrochloric acid, and stirring until foaming to obtain acetalized polyvinyl alcohol; and adding the polyvinyl alcohol / chitosan blended solution into the acetalized polyvinyl alcohol, injecting into a mold for solidifying to prepare the chitosan compound acetalized polyvinyl alcohol medical dressing. The medical dressing prepared by the method has biocompatibility, can promote wound healing, has high tensile strength, excellent air permeability, water absorption and foamability, does not have remarkable cytotoxicity, and can be used for treating wounds.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical dressings, and relates to the preparation technology of polyvinyl alcohol sponges, in particular to a preparation method of chitosan composite acetalized polyvinyl alcohol medical dressings. Background technique [0002] The correct treatment of surgical wounds is one of the keys to the success of surgical treatment, and good wound healing is the prerequisite for the recovery of body functions after trauma. Therefore, research on accelerating wound healing is very important, and the development of wound dressings is one of the hotspots of research. one. Research on wound healing shows that the purpose of using dressings is not only to cover the wound surface, but also to promote wound healing. According to the "moist wound healing" theory, wounds heal faster in a moist environment. [0003] With the advancement of material science and industrial science, wound dressings have under...

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Problems solved by technology

Such as Chinese patent 200510018241.X discloses a kind of gradient structure chitosan hydrogel burn dressing and preparation method thereof; Chinese patent CN02127182.8 discloses multi-layer structure microporous foam dressing and manufacturing method thereof; A hydrophilic polyurethane wound dressing and its preparation method are disclosed; Chinese patent CN88105184.5 discloses a production method of a medical polymer transparent dressing; Cheng Liping et al. Research on the effect of bacteria, 2004.4.240-243] on the preparation of polyurethane antibacterial wound dressing and its sterilization effect; Peng Rui et al [Peng Rui, Zou Yang, Liu Yong. Preparation and Analysis of physical and chemical properties. Journal of Clinical and Experimental Medicine. 2007. 6. 142 -143] also analyzed the preparation and physical and chemical properties of gelatin and bletilla striata gum drug-loaded biological dressings; Chinese patent 200410010849.3 discloses poly Vinyl alcohol hydrogel dressing and its preparation method, but this method uses radiation crosslinking method, the preparation process is complicated, the mechanical strength of the product is not enough, the tensile strength is not ideal, and it is easy to damage

At present, domestic medical sponges on the market generally have disadvantages such as low strength, poor resistance to wound adhesion, and easy inflammation.

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