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Composite microballoon with functions of dual mode imaging and photodynamic activity and preparation method thereof

A dual-mode imaging and composite microsphere technology, which is applied in the preparation of microspheres, medical preparations containing active ingredients, phototherapy, etc., can solve the problems of difficult control of ingredients, affecting optical imaging, and difficult to prepare materials repeatedly. The effect of overcoming poor detection accuracy, simple preparation process, and wide application prospects

Inactive Publication Date: 2013-12-18
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these composite materials that combine magnetic and luminescent substances have serious problems in the process of preparation and biological application. First, the composition of the two substances is not easy to control during the preparation process, and it is difficult to repeatedly prepare magneto-optical materials. materials with consistent properties; secondly, the structure of composite materials is complex, and the cumbersome preparation process is likely to adversely affect the basic properties of materials; the most important problem is that magnetic iron oxide particles have extremely strong absorption properties in the visible light region, which is easy to reduce It even quenches the luminous intensity of luminescent substances, which in turn affects the effect of optical imaging or application using fluorescence properties; especially the current development of magnetic-luminescent materials is limited to imaging detection applications and does not have photodynamic activity and other functions.

Method used

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  • Composite microballoon with functions of dual mode imaging and photodynamic activity and preparation method thereof
  • Composite microballoon with functions of dual mode imaging and photodynamic activity and preparation method thereof
  • Composite microballoon with functions of dual mode imaging and photodynamic activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 The preparation method of the composite microspheres with dual-mode imaging and photodynamic therapy functions is as follows:

[0055] NaGdF stabilized with oleic acid 4 : 20%Yb 3+ / 2%Er 3+ Upconversion nanocrystals dispersed in CH 2 Cl 2 , the concentration is 10mg / mL; the photosensitizer zinc phthalocyanine (ZnPc) is dispersed in tetrahydrofuran (THF) solvent to prepare a saturated solution of ZnPc in THF, and the alternating copolymer (PMAO) of octadecene and maleic anhydride is dissolved in CH 2 Cl 2 In , the concentration is 10mg / mL. Take 0.4mL NaGdF respectively 4 : Yb 3+ / Er 3+ solution, 0.3mL of PMAO solution, and 0.15mL of ZnPc saturated solution in THF were added to the reactor to prepare NaGdF 4 : Yb 3+ / Er 3+ , ZnPc, PMAO mixed solution system, add 0.15mL CH 2 Cl 2 Bring the total organic volume to 1 mL.

[0056] Weigh 50 mg of sodium dodecylsulfonate (SDS) and dissolve it in 10 mL of deionized water, and the prepared NaGdF 4 : Yb ...

Embodiment 2

[0063] Example 2 The preparation method of the composite microspheres with dual-mode imaging and photodynamic therapy functions is as follows:

[0064] NaGdF stabilized with oleic acid 4 : 20%Yb 3+ / 2%Er 3+ Upconversion nanocrystals dispersed in CH 2 Cl 2 , the concentration is 10 mg / mL; take 545nm up-conversion luminescent sensitized photosensitive molecular merocyanine 540 (M-540) and disperse it in tetrahydrofuran (THF) solvent to prepare a THF saturated solution of M-540; take octadecene Alternating copolymer with maleic anhydride (PMAO) dissolved in CH 2 Cl 2 In , the concentration is 10mg / mL. Take 0.4mLNaGdF 4 : Yb 3+ / Er 3+ solution, 0.2mL of PMAO solution, and 0.15mL of M-540 saturated solution in THF were added to the reactor to prepare NaGdF 4 : Yb 3+ / Er 3+ , M-540, PMAO mixed solution system, add 0.25mL CH 2 Cl 2 Bring the total organic volume to 1 mL.

[0065] Weigh 56 mg of dodecyltrimethylammonium bromide (DTAB) and dissolve it in 10 mL of deioniz...

Embodiment 3

[0069] Example 3 The preparation method of the composite microspheres with dual-mode imaging and photodynamic therapy functions is as follows:

[0070] NaGdF stabilized with oleic acid 4 : 20%Yb 3+ / 2%Er 3+Upconversion nanocrystals dispersed in CH 2 Cl 2 , the concentration is 10mg / mL; the photosensitizer zinc phthalocyanine (ZnPc) is dispersed in tetrahydrofuran (THF) solvent to prepare a saturated solution of ZnPc in tetrahydrofuran, and polymaleic anhydride-styrene copolymer (PSMA) is dissolved in CH 2 Cl 2 In , the concentration is 10mg / mL. Take 0.4mL NaGdF respectively 4 : Yb 3+ / Er 3+ solution, 0.3mL of PMAO solution, and 0.15mL of ZnPc saturated solution in THF were added to the reactor to prepare NaGdF 4 : Yb 3+ / Er 3+ , ZnPc, PMAO mixed solution system, add 0.15mL CH 2 Cl 2 Bring the total organic volume to 1 mL.

[0071] Weigh 50 mg of sodium dodecylsulfonate (SDS) and dissolve it in 10 mL of deionized water, and the prepared NaGdF 4 : Yb 3+ / Er 3+ ,...

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Abstract

The invention discloses a composite microballoon with functions of dual mode imaging and photodynamic activity and a preparation method thereof. The composite microballoon comprises hydrophobic polymer, hydrophobic photosensitizer and up-conversion luminescence nanocrystals. The preparation method comprises the following steps: dissloving stable oil-soluble up-conversion luminescence nanocrystals, hydrophobic polymer, and hydrophobic photosensitizer in organic solvent, then adding an aqueous solution containing a surfactant, carrying out emulsification to form a stable micoemulsion system, removing the organic solvent from the micoemulsion system through evaporation, carrying out centrifugation to obtain sediment in the residual solution, and purifying the sediment to obtain an object product. The composite microballoon disclosed herein combines optical imaging, magnetic resonance imaging and other functions and photodynamic activity together, can be applied for imaging detection and photodynamic treatment, and has the advantages of simple process and simple operation. The present invention has a wide application prospect in the fields of biology, medical science and the like.

Description

technical field [0001] The invention relates to a composite microsphere in the technical field of nanomaterial bioimaging and treatment, in particular to a composite microsphere integrating up-conversion luminescence and magnetic resonance dual-mode imaging and photodynamic activity functions and a preparation method thereof. Background technique [0002] Imaging detection and photodynamic therapy are important methods for disease diagnosis and treatment, among which dual-mode biological imaging has higher accuracy in diagnosis, and photodynamic therapy has the unique advantages of minimal invasiveness and targeting. [0003] With the development of nano-biomedical research, the biological application research of constructing magneto-optical composite materials with fluorescent and magnetic materials for imaging detection has become a hot spot in the field of nanomaterials research. Among them, magneto-optical composite materials with superparamagnetic iron oxide nanoparticl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02A61K41/00A61K9/16A61K49/12A61K49/18A61B6/00A61N5/06
Inventor 张庆彬王新朱毅敏杨辉
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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