Preparation method of vitamin K2 compound

A compound and metal compound technology, applied in the field of organic drug synthesis, can solve the problems of unsuitability for industrial production, cumbersome operation, harsh conditions, etc., and achieve the effects of easy separation and purification, less pollution, and mild reaction conditions
CN102485709AActive Publication Date: 2012-06-06天津康鸿医药科技发展有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
天津康鸿医药科技发展有限公司
Publication Date
2012-06-06

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Abstract

The invention provides a preparation method of a vitamin K2 compound. The preparation method comprises the following steps that a compound shown by the formula 2, a carbonyl protective agent and a bromination agent undergo a reaction to produce a compound shown in the formula 3; the compound shown in the formula 3 and a long-chain olefin metal compound undergo a reaction in the presence of catalysts to produce a compound shown in the formula 4; and the compound shown in the formula 4 reacts under an acid catalysis condition to produce a compound shown in the formula 1, wherein n represents an integer of 0 to 10, such as 1, 3, 6 or 8; and R represents C1-C4 of O,O-, O,S- and S,S-ketal and acetal (comprising annular ketal and acetal), O,O,O-orthoester, O,S,S-orthoester, S,S,S-orthoester, alkenyl ether, sulfo-alkenyl ether and enamine. The preparation method has the advantages of mild reaction conditions, less side reactions, poor product decomposability, relatively simple deprotection reaction conditions and high yield.
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Description

technical field

[0001] The invention belongs to the field of organic medicine synthesis, and in particular relates to a synthesis method of vitamin K2 compounds. Background technique

[0002] In 1934, Danish scientists first discovered vitamin K and confirmed that it is a fat-soluble vitamin. Vitamin K is a class of naphthoquinone derivatives with biological activity of phylloquinone, and is one of the indispensable and important vitamins in the human body. Naturally occurring vitamins K1 and K2, among which vitamin K1 is widely found in green plants and is an important source of vitamin K in food; vitamin K2 is mainly synthesized by intestinal bacteria.

[0003] Vitamin K2 can be used to treat and prevent osteoporosis, increase bone density, prevent fractures; prevent liver cirrhosis from developing into liver cancer; treat vitamin K2 deficiency hemorrhage, promote the formation of prothrombin, accelerate coagulation, and maintain normal coagulation time; It also has a di...

Claims

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