Preparation technology for compound aquatic organism collagen peptide-calcium complex, technology for preparing calcium supplement from complex, and application of calcium supplement

A preparation process and compound technology, which can be applied in application, food preparation, drug combination and other directions, can solve the problems of insufficient absorption rate, low bioavailability, large side effects, etc., and achieve prevention and improvement of osteoporosis symptoms and broad market application. Prospects, the effect of promoting the formation of bone matrix

Active Publication Date: 2012-06-20
THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The calcium supplements currently used clinically, the first generation is calcium carbonate, and the second generation is organic acid calcium, both of which are ionized calcium, with poor stability, many factors affecting absorption, low bioavailability, large side effects, and insufficient absorption rate. 40%; the third generation is amino acid chelated calcium. Calcium can use free amino acids as a carrier. The entire molecule of calcium and its organic groups is completely absorbed by the intestinal tract, which belongs to the unsaturated absorption process, avoids the generation of hypercalcemia, and has anti It has the advantages of strong interference, good stability, and easy absorption, but its production cost is high, which greatly limits its application; the fourth ge

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]Example 1: Put 50Kg of dried fish scales into a reaction kettle containing 500L of 1.0mol / L sulfuric acid solution, control the hydrolysis temperature at 50°C, and carry out hydrolysis for 1 hour. After cooling the hydrolyzate, remove the sediment by a continuous flow centrifuge, and The supernatant is deacidified, separated and purified, desalted and concentrated through multi-layer membrane integrated purification systems such as ultrafiltration, microfiltration, nanofiltration and dialysis membranes to obtain collagen peptide hydrolyzate with a molecular weight of 5-15KDa. The hydrolyzate is directly treated with Ca(OH) 2 Adjust the pH to 6~8; then stir and react under normal pressure at 60°C for 2 hours, and the reaction solution passes through a multi-component membrane integrated purification and separation system to remove free metal element calcium and inorganic salts that are not coordinated with the collagen peptide, and then obtain the calcium coordination comp...

Embodiment 2

[0037] Example 2: Put 50Kg of dried fish skin into a reaction kettle containing 500L of 0.5mol / L sulfuric acid solution, control the hydrolysis temperature at 85°C, and carry out hydrolysis for 4 hours. After the hydrolyzate is cooled, the sediment is removed by a continuous flow centrifuge , the supernatant is deacidified, separated and purified, desalted and concentrated through multi-component membrane integrated purification systems such as ultrafiltration, microfiltration, nanofiltration and dialysis membranes to obtain collagen peptide hydrolyzate with a molecular weight of 1-8KDa. Use NaOH to adjust the pH of the hydrolyzate to 6~8, then add metal element calcium equal to the molar content of amino nitrogen in the hydrolyzate, the metal element calcium is added in the form of calcium salt, calcium nitrate or calcium chloride can be added, and stirred at 25 °C under normal pressure After reacting for 12 hours, the reaction solution is passed through a multi-component memb...

Embodiment 3

[0038] Embodiment three: put 20Kg of dried fish scales into a reaction kettle containing 300L of 0.1mol / L hydrochloric acid solution, control the hydrolysis temperature at 90°C, and carry out hydrolysis for 8 hours. After the hydrolyzate is cooled, the sediment is removed by a continuous flow centrifuge. The supernatant is deacidified, separated and purified, desalted and concentrated through multi-membrane integrated purification systems such as ultrafiltration, microfiltration, nanofiltration and dialysis membranes to obtain collagen peptide hydrolyzate with a molecular weight of 7-13KDa. Use NaOH to adjust the pH of the hydrolyzate to 6~8, then add metal element calcium equal to the molar content of amino nitrogen in the hydrolyzate, the metal element calcium is added in the form of calcium salt, calcium nitrate or calcium chloride can be added, and stirred at 40°C under normal pressure After reacting for 12 hours, the reaction solution was passed through a multi-component m...

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Abstract

The invention relates to a preparation technology for an aquatic organism collagen peptide-calcium complex. The preparation technology comprises the following steps: 1, hydrolyzing raw materials of processed natural fish scales and fish skins by an inorganic acid or an organic acid to prepare a collagen peptide hydrolysate; 2, removing the sediment from the collagen peptide hydrolysate, carrying out depickling, separating purification and desalination concentration on the obtained supernatant to obtain a collagen peptide hydrolysate with the molecular weight of 1-20KDa; and 3, adjusting the pH value of the collagen peptide hydrolysate to 6-8, adding a calcium salt with the metal element calcium mole content equal to the mole content of amino nitrogen in the hydrolysate, and removing free metal element calcium and the inorganic salt which are uncomplexed from the obtained reaction liquid to obtain the liquid collagen peptide-calcium complex. The complex is added with vitamin D3 and ascorbic acid to prepare a compound aquatic organism collagen peptide-calcium supplement. The calcium supplement which can be used as a medicine for preventing and controlling diseases with symptoms of osteoporosis and the like and a functional health food can also be used as a safe high efficiency calcium nutriment and a vitamin D3 and ascorbic acid supplement.

Description

technical field [0001] The present invention relates to the technical field of health food or medicine, especially a preparation process for preparing aquatic collagen peptide calcium coordination compound by chelating or complexing aquatic collagen peptide and metal element calcium, and a compound aquatic collagen peptide calcium supplement Preparation process, and the application of the calcium supplement in health food and medicine. Background technique [0002] Calcium is the most abundant mineral element necessary for the human body, accounting for 1.5-2.0% of the body weight, and it undertakes important physiological functions in the body. However, the dietary pattern of Chinese people is mainly based on cereals, and the calcium intake is generally low, only reaching about 50% of the recommended amount, and due to the difference in the human body's ability to absorb calcium, the calcium absorption rate is low. Calcium deficiency is a common nutritional problem. From i...

Claims

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Application Information

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IPC IPC(8): A23L1/305A23L1/304A23L1/327A61K38/39A61P3/02A61P19/10A23L17/20
Inventor 孙继鹏易瑞灶陈晖陈俊德郭洪辉陈思谨张怡评
Owner THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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