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Preparation method of quantum dot polymer microspheres

A quantum dot polymer, quantum dot technology, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of uneven distribution and large particle size of quantum dot polymer microspheres, and achieve uniform particle size and adjustable size. Effect

Inactive Publication Date: 2012-06-20
WUXI ZODOLABS BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the particle size of quantum dot polymer microspheres prepared by suspension polymerization is large and the distribution is very uneven, which is greatly restricted in the application process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] Preparation method of quantum dots such as CdSe:

[0025] (1) Get 0.09g of selenium powder, place in a flask adding 30ml of octadecene, heat to 200°C under nitrogen protection, keep the temperature at a constant temperature for 20 minutes, and cool to room temperature to obtain a selenium stock solution;

[0026] (2) Mix 0.06g CdO, 0.5g stearic acid and 20ml octadecene in a beaker, heat at 150°C under nitrogen protection, keep the temperature constant for 20 minutes, and cool to room temperature to obtain a cadmium stock solution;

[0027] (3) Take the above 0.5ml cadmium stock solution, add 0.25g tri-n-octylphosphine oxide and hexadecylamine, heat at 260°C under nitrogen protection, keep for 20 seconds, quickly remove the heating device to cool the product to room temperature.

[0028] (4) Add n-hexane to the product, centrifuge, discard the precipitate, add acetone, let stand for 10 minutes to precipitate the product, discard the supernatant, and obtain CdSe quantum d...

Embodiment 1

[0030] (1) Add the organic phase composed of 80g styrene, 10g divinylbenzene, 0.1g CdSe quantum dots and 3g benzoyl peroxide into the oil phase storage tank, and form a uniform oil phase fluid through stirring;

[0031] (2) Add 1000ml of distilled water and 10g of polyvinyl alcohol into the stirred polymerization reactor, stir at 80°C for 30 minutes, completely dissolve the polyvinyl alcohol, and keep the stirring speed at 200rpm;

[0032] (3) Pressurize to keep the pressure in the oil phase storage tank at 0.1MPa, open the second regulating valve, the oil phase fluid is dispersed into the water phase in the polymerization reactor through the nozzle to form an O / W suspension, and react at a constant temperature of 80°C for 3h ;

[0033] (4) After cooling, CdSe quantum dot polystyrene microspheres can be obtained through centrifugal separation, washing, drying and other processes.

Embodiment 2

[0035] (1) Add the organic phase composed of 70g methyl methacrylate, 5g ethylene glycol dimethacrylate, 0.1g CdSe quantum dots and 4g benzoyl peroxide into the oil phase storage tank, and form a uniform mixture after stirring oil phase fluid;

[0036] (2) Add 1000ml of distilled water and 15g of polyvinylpyrrolidone into the stirred polymerization reactor, and stir at 80°C for 30 minutes to completely dissolve the polyvinylpyrrolidone, and keep the stirring speed at 200rpm;

[0037] (3) Appropriate pressure is added to keep the pressure in the oil phase storage tank at 0.1 MPa, and the second regulating valve is opened, and the oil phase fluid is dispersed into the water phase in the polymerization reactor through the nozzle to form an O / W suspension;

[0038] (4) Constant temperature polymerization reaction at 80°C for 3 hours, after cooling, centrifugation, washing, drying and other processes, the CdSe quantum dot polymethyl methacrylate microspheres can be obtained.

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Abstract

The invention discloses a preparation method of quantum dot polymer microspheres, which comprises the following steps that: hydrophobic monomer, oil soluble quantum dot and oil soluble initiator are fully mixed to form uniformly scattered oil phase fluid; jet-flow suspension polymerization is adopted to break and scatter the oil phase fluid into oil drops with uniform sizes, and O / W type suspension liquid forming in the water phase is subjected to polymerization at the constant temperature to form quantum dot polymer microspheres with uniform sizes. The quantum dot polymer microspheres prepared by the method is uniform in grain sizes, controllable in the sizes of the microspheres, high in fluorescence efficiency and stable in chemical properties, thereby having potential application values in the field of biological tests and medical science.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a preparation method of quantum dot polymer microspheres. Background technique [0002] Fluorescence is a kind of cold luminescence phenomenon of photoluminescence. When a substance at room temperature is irradiated by incident light of a certain wavelength (usually ultraviolet or X-ray), it enters an excited state after absorbing the light energy, and immediately de-excites and emits outgoing light with a wavelength longer than the incident light (usually with a wavelength of visible light) band), and once the incident light is stopped, the luminescence disappears immediately. The outgoing light with this property is called fluorescence. In recent years, as a new type of functional material, fluorescent microspheres have played an important role in biomedical fields such as fluorescent immunoassay, biosensor and high-throughput drug screening due to their special morphological...

Claims

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Application Information

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IPC IPC(8): C08F212/08C08F212/36C08F2/44C08K3/30C08K3/32C08K3/10C08F2/20C08F220/14C08F222/14C08F218/08C08F220/32C09K11/88C09K11/70C09K11/74C09K11/02
Inventor 阳承利
Owner WUXI ZODOLABS BIOTECH
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