Dental implant and preparation method thereof

A dental implant and implant technology, applied in dental preparations, dental prostheses, dentistry, etc., can solve problems such as cumbersome steps, achieve the effect of increasing the rate of osseointegration, shortening the time of osseointegration, and improving the success rate of implantation
CN102579145AActive Publication Date: 2012-07-18FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FOURTH MILITARY MEDICAL UNIVERSITY
Publication Date
2012-07-18

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Abstract

The invention relates to the field of dental implant materials, and discloses a dental implant carrying miRNA (micro-ribonucleic acid) or siRNA (small interfering ribonucleic acid) and a preparation method thereof. The outer surface of the dental implant is a microarc oxidation coating with micro / nano appearance, wherein factors promoting osteogenic differentiation are loaded on the microarc oxidation coating, and are miRNA or siRNA. The preparation method comprises the following steps: processing pure titanium or titanium alloy into an implant matrix; polishing, cleaning and blow-drying; producing the microarc oxidation coating with micro / nano appearance on the outer surface of the implant matrix by adopting a microarc oxidation process, cleaning and blow-drying; mixing liposome and miRNA or siRNA to produce a carrier mixture; immersing the implant matrix into the carrier mixture, freezing with drikold; and loading the carrier mixture to the microarc oxidation coating by adopting a vacuum lyophilisation process, and standing at normal temperature to obtain the dental implant carrying miRNA or siRNA.
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Description

technical field

[0001] The invention relates to a dental implant material, in particular to a dental implant loaded with miRNA or siRNA and a preparation method thereof. Background technique

[0002] With the development of implant technology, dental implants have been widely used in the restoration of clinical dentition defects and missing patients. However, after implant placement, osseointegration takes a long time. Generally speaking, implants can be repaired after 3-6 months. Especially for some special patients, such as diabetes and osteoporosis, it is more difficult to implement implants. Reluctant implants often lead to failure cases. This greatly perplexes patients and dentists.

[0003] Nowadays, in order to increase the rate of osseointegration and shorten the time of osseointegration, various implant surface topography has appeared and been applied clinically, mainly using technologies such as Microarc Oxidation (MAO), titanium slurry spraying or sandblasting a...

Claims

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