Lyophilized inactivated Japanese encephalitis vaccine

A Japanese encephalitis and inactivation technology is applied in the field of new freeze-dried and inactivated Japanese encephalitis whole virus vaccines, which can solve the problems of low miscellaneous protein content and instability of purified vaccines, and achieve clear components, easy quantitative and qualitative, and stable long term effect
CN102631672AActive Publication Date: 2012-08-15天津嘉诚顺隆商贸有限公司

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
天津嘉诚顺隆商贸有限公司
Publication Date
2012-08-15

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Abstract

The invention provides a lyophilized inactivated Japanese encephalitis vaccine, comprising: (a) inactivated Japanese encephalitis totivirus; (b) stabilizer, which comprises maltose, lactose, and optionally mycose, mannite, sorbitol and / or amino acid; and optionally (c) buffer, surfactant, isotonic regulator and / or chelating agent.
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Description

technical field

[0001] The invention relates to a novel freeze-dried and inactivated Japanese encephalitis whole virus vaccine. Background technique

[0002] The pathogen of epidemic encephalitis B (JE) was discovered in Japan in 1934, so it is also called Japanese Encephalitis. Japanese encephalitis virus belongs to the flavivirus genus of Togaviridae. The spherical virus particles have capsules outside, and are sensitive to temperature, ether and other organic solvents. The Japanese encephalitis virus is transmitted by mosquitoes and is prevalent in summer and autumn. There are about 50,000 cases of the disease every year in the world, and the main endemic areas are countries such as southern my country, Southeast Asia, and tropical regions. WHO recommends that all JE-endemic countries should implement JE vaccine immunization.

[0003] JE vaccines currently used internationally are mainly inactivated whole virus JE vaccines and live attenuated JE vaccines. Maintaining g...

Claims

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