Lywallzyme of phage of staphylococcus aureus as well as preparation method and application thereof

A Staphylococcus aureus technology, applied in the field of bioengineering, can solve problems such as multi-drug resistance, Staphylococcus aureus drug resistance, and difficult clinical treatment.
CN102676490BActive Publication Date: 2013-07-31JIANGSU ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU ACAD OF AGRI SCI
Publication Date
2013-07-31

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Abstract

The invention relates to the field of biological engineering, and in particular relates to lywallzyme (or catenase) of phage of staphylococcus aureus and an application thereof as an antibacterial material in preventing and treating bouine mastitis and controlling food pollution. The amino acid sequence of the lywallzyme of phage of staphylococcus aureus is SeqIDNO2. Zymin capable of efficiently killing staphylococcus aureus is developed by a bioengineering technique. The zymin can be used independently or with other agents to inactivate staphylococcus aureus specifically so as to provide a safe zymin source without toxic and side effects for preventing and treating bouine mastitis and controlling staphylococcus aureus pollution in food.
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Description

technical field

[0001] The invention belongs to the field of bioengineering, in particular to a Staphylococcus aureus bacteriophage lysase (or lyase) and its application as an antibacterial substance in the prevention of dairy cow mastitis and the control of food pollution. Background technique

[0002] Cow mastitis not only brings huge economic losses to the world dairy industry, but also endangers public health and human health. Research data show that Staphylococcus aureus is the main pathogenic bacteria causing mastitis in dairy cows, and the cases of mastitis in cows caused by it reach 74%. Up to 350 million.

[0003] The main cause of mastitis in dairy cows is the infection of pathogenic microorganisms, among which Staphylococcus aureus ( Staphyloccus aureus ), Streptococcus and Escherichia coli, accounting for more than 90% of cow mastitis cases. Among them, SA is the most important pathogen causing mastitis, and it is also the most difficult to treat clinically an...

Claims

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