Cuttlebone transformation series porous composite bio-ceramic, its preparation method and application

A technology of bioceramics and cuttlebone, applied in medical science, prosthesis, etc., can solve the problems of easy breakage or even pulverization, difficult degradation of materials, complex process, etc., and achieve simple and stable production process, low reaction temperature, and large contact area Effect

Inactive Publication Date: 2012-11-07
李亚屏
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  • Abstract
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Problems solved by technology

Chinese Patent Publication No. CN101987208A discloses a cuttlebone transformation heterogeneous large-aperture bone regeneration scaffold material and its preparation method. It is made of cuttlebone and ammonium dihydrogen phosphate through secondary hydrothermal reaction (under high pressure conditions) and high-temperature sintering. It is more complex, and more importantly, the properties of materials after high-temperature sintering and those without high-temperature sintering are quite different. The brittleness of high-temperature sintered products is significantly increased, and they are easily broken or even powdered when stressed, which also makes the material difficult to degrade.

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  • Cuttlebone transformation series porous composite bio-ceramic, its preparation method and application
  • Cuttlebone transformation series porous composite bio-ceramic, its preparation method and application
  • Cuttlebone transformation series porous composite bio-ceramic, its preparation method and application

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Embodiment 1

[0057] Cuttlebone porous bone mineral scaffold (CaCO 3 ) 2.5g, 3.0ml of phosphoric acid with a mass concentration of 85%, and 30ml of phosphoric acid solution was prepared with distilled water, and the pH of the phosphoric acid solution was 1 before the reaction. The cuttlebone porous bone mineral support was immersed in phosphoric acid solution, reacted at a constant temperature of 60 °C, the sample was washed, dried in an oven at 50 °C, and detected by X-ray diffraction (XRD).

[0058] Reaction for 1 hour to obtain calcium carbonate / anhydrous calcium hydrogen phosphate / dihydrate calcium hydrogen phosphate porous composite bioceramics, the mass fraction of each component is: calcium carbonate 33.1%, anhydrous calcium hydrogen phosphate 52.6%, dihydrate calcium hydrogen phosphate 14.3% ;

[0059] After reacting for 2 hours, anhydrous calcium hydrogen phosphate / calcium dihydrogen phosphate porous composite bioceramic was obtained. The mass fraction of each component was: anhyd...

Embodiment 2

[0062] Add 0.72ml of phosphoric acid with a mass concentration of 85%, add 20ml of distilled water to prepare 20.72ml of phosphoric acid solution, pH of phosphoric acid solution before reaction is 1. 1.5 g of cuttlebone porous bone mineral support was immersed in it, reacted at a constant temperature of 25 °C, the sample was cleaned, dried in an oven at 50 °C, and detected by X-ray diffraction (XRD).

[0063] h The reactant is calcium carbonate / calcium hydrogen phosphate dihydrate porous composite bioceramic, the mass fraction of each component is: calcium carbonate 26.1%, calcium hydrogen phosphate dihydrate 73.9%.

[0064]

Embodiment 3

[0066] Cuttlebone porous bone mineral scaffold (CaCO 3 ) 2.5g, mass concentration 85% phosphoric acid 1.2ml, prepare phosphoric acid solution 21.2ml with distilled water, add potassium hydroxide to pH 3.5. The cuttlebone porous bone mineral support was immersed in phosphoric acid solution, reacted at a constant temperature of 60 °C, the sample was washed, dried in an oven at 60 °C, and detected by X-ray diffraction (XRD).

[0067] React for 1.5 hours to get calcium carbonate / anhydrous calcium hydrogen phosphate / octacalcium phosphate / dihydrate calcium hydrogen phosphate porous composite bioceramics, the mass fraction of each component is: calcium carbonate 41%, anhydrous calcium hydrogen phosphate 26.6%, octacalcium phosphate Calcium 16.8%, calcium hydrogen phosphate dihydrate 15.6%;

[0068]React for 3.5 hours to get calcium carbonate / anhydrous calcium hydrogen phosphate / octacalcium phosphate / dihydrate calcium hydrogen phosphate porous composite bioceramics, the mass fraction...

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Abstract

The invention relates to the technical field of medical material production and aims to provide a cuttlebone transformation series porous composite bio-ceramic, which contains at least two organic components in human bone mineral. According to the ceramic, cuttlebone's exquisite three-dimensional intercommunicated mesh structure, effective mechanical structure--truss structure and crystal form of cuttlebone biological self assembly ceramic and connection of crystals are remained. The ceramic provided by the invention has high porosity and ideal aperture, and simultaneously has good mechanical strength and biocompatibility. As a precursor, a cuttlebone porous bone mineral scaffold is transformed to form the cuttlebone transformation series porous composite bio-ceramic by the addition of phosphoric acid in a first-stage wet process or by the addition of soluble phosphatic and phosphoric acid in a second-stage wet process. The cuttlebone transformation series porous composite bio-ceramic at least contains two components from the following human bone mineral components of: calcium carbonate, dihydrate calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate, octacalcium phosphate, hydroxyapatite and carbonated hydroxyapatite.

Description

technical field [0001] The invention relates to the technical field of medical material production, in particular to a cuttlebone transformation series porous multiphase bioceramic and its preparation method and application. Background technique [0002] Bone grafting is required for bone defects caused by accidents, bone disease, war, or orthopedic surgery. There are more than 3 million patients who need bone transplantation every year in China. Autologous bone grafting is the gold standard for the treatment of bone defects, but the source of autologous bone is limited, adding new trauma to the patient, and there will be certain complications in the bone harvesting area. Currently, the materials used to replace autologous bone grafts are mainly allogeneic bone and artificial bone substitute materials. Although allogeneic bone has osteogenic conduction, it is immunogenic and may spread pathogens, or cause some social and ethical issues. [0003] Organic matter is the mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/56C04B35/622
Inventor 李亚屏汤亭亭李星彭兆祥熊汉峰李桑李振波
Owner 李亚屏
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