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Hydrotalcite tablet and its preparation method

A technology of magnesium carbonate tablets and magnesium carbonate, applied in the field of gastric medicine, can solve the problems of long antacid action time, failure to solve the disintegration time of aluminum magnesium carbonate, etc., and achieves uniform dispersion of the main drug, long antacid effect maintenance time, The effect of short production cycle

Active Publication Date: 2012-12-12
CHONGQING PHARSCIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] But it still does not solve the defects of long disintegration time, low acid-making power and short action time in the prior art.

Method used

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  • Hydrotalcite tablet and its preparation method
  • Hydrotalcite tablet and its preparation method
  • Hydrotalcite tablet and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: per 1000 dosage

[0030]

[0031]Preparation method: Weigh micronized aluminum magnesium carbonate, 50% croscarmellose sodium, xylitol, microcrystalline cellulose, citric acid, sodium lauryl sulfate, sodium saccharin, mix well, pass 120 mesh screen. Use 80% ethanol solution to make polyvinylpyrrolidone (K90) into ethanol solution with a concentration of 2%, add it to the above powder, use high-efficiency wet granulation mechanism soft material, and pass the obtained particles through a 24-mesh sieve at 50 ° C. Dry, granulate with 24 meshes, add remaining 50% croscarmellose sodium, menthol, magnesium stearate, talcum powder. Mix evenly, and press into tablets with a weight of about 1g per tablet.

Embodiment 2

[0032] Embodiment 2: per 1000 dosage

[0033]

[0034] Preparation method: Weigh micronized aluminum magnesium carbonate, 50% low-substituted hydroxypropyl cellulose, mannitol, precrossified starch, maleic acid, sodium lauryl sulfate, steviol glycoside, mix well, pass through 150 mesh sieve. Prepare hypromellose (E50) into a 10% aqueous solution, add it to the above-mentioned powder, use a high-efficiency wet granulation mechanism to make the soft material, pass the granules through a 30-mesh sieve, dry at 60°C, and dry them with a 30-mesh sieve. granules, add the remaining 50% of the amount of low-substituted hydroxypropyl cellulose, magnesium stearate, menthol. Mix evenly, and press into tablets with a weight of about 1.5g per tablet.

Embodiment 3

[0035] Embodiment 3: per 1000 dosage

[0036]

[0037]

[0038] Preparation method: Weigh micronized aluminum magnesium carbonate, 50% low-substituted hydroxypropyl cellulose, croscarmellose sodium, lactose, microcrystalline cellulose, tartaric acid, steviol glycoside, mix well, pass through 120 mesh sieve. Use 30% ethanol solution to prepare polyvinylpyrrolidone (K30) into a 6% ethanol solution, add it to the above powder, use a high-efficiency wet granulation mechanism to make the soft material, and pass the prepared granules through a 30-mesh sieve. Dry, granulate with 30 meshes, add the remaining 50% low-substituted hypromellose, croscarmellose sodium, magnesium stearate, silicon dioxide, and menthol. Mix evenly, and press into tablets with a weight of about 0.7g per tablet.

[0039] Sample acid test

[0040] Inspection method: take a few pieces of this product, grind them finely, take an appropriate amount of fine powder, approximately equivalent to 0.5g of alumi...

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Abstract

The invention relates to a gastric antiacid, and concretely relates to a hydrotalcite tablet and its preparation method. The hydrotalcite tablet comprises 33.3-71.4wt% of micronized hydrotalcite, 0.5-5wt% of a weakly-acidic pH adjustment agent, 0.5-2wt% of sodium dodecyl sulfate, 3-8wt% of a low-substituted hydroxypropylcellulose or a crosslinked carboxymethylcellulose sodium, 1-2.2wt% of polyvinylpyrrolidone or hydroxypropyl methylcellulose, 0.5-1.5wt% of a lubricant, 0.2-0.5wt% of menthol, and the balance a filler and other pharmaceutically acceptable assistants. The invention correspondingly provides the preparation method of the hydrotalcite tablet. The hydrotalcite tablet provided by the invention has the advantages of fast collapse and long acid inhibition maintenance time.

Description

technical field [0001] The invention relates to a stomach medicine, that is, an antacid medicine, in particular to a aluminum magnesium carbonate tablet and a preparation method thereof. Background technique [0002] Aluminum magnesium carbonate is a new type of long-acting antacid, its molecular structure is arranged in a layered lattice, and it has a variety of pharmacological effects. The first is to neutralize gastric acid: 1g hydrochloric acid can neutralize 27.1mmol ~ 27.8mmol of hydrochloric acid to generate two kinds of insoluble salts, water and carbon dioxide. When the pH is less than 3, the drug starts the neutralization reaction; when the pH=5, the reaction is terminated; when the pH is less than 3, the reaction starts again. Therefore, this drug can maintain the pH value of the stomach between 3 and 5, neutralize 99% of gastric acid, and inactivate 80% of pepsin. The anti-acid effect of this product has the characteristics of rapid action, mild effect and long...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K33/10A61K47/20A61K47/12A61K47/36A61K47/26A61K47/38A61P1/04
Inventor 张壹苏跃林沈浩陈烈春刘伟王道权杭永禄刘小英游洪涛王瑛
Owner CHONGQING PHARSCIN PHARM CO LTD
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