Bioabsorbable polymer scaffold matrix as well as preparation method and application thereof

Abstract

The invention discloses a bioabsorbable polymer scaffold matrix. The scaffold matrix is formed via a method shown as follows: processing a bioabsorbable polymer tube through laser to form a scaffold structure in a graving manner; forming holes on the surface of the graved scaffold, so as to achieve high-density holes at a micron level on the surface; and then activating the surface through plasma. The scaffold matrix can be used for carrying medicine, thus, the scaffold matrix can be prepared into the bioabsorbable polymer medicine bearing scaffold. Compared with the prior art, the scaffold matrix has higher scaffolding force, and smaller outside diameter, therefore, the conveying performance of the scaffold in the blood vessel of a human body can be improved;, and the scaffold can easily pass through narrow diseased tissue; and the bioabsorbable polymer scaffold matrix has the advantages of safety, efficiency and practicability. The invention also discloses a preparation method of the scaffold matrix. The preparation method has the characteristics of simple technology, and reduced cost.

Description

technical field [0001] The invention relates to a polymer material medical device for percutaneous interventional therapy, in particular to a bioabsorbable polymer bracket matrix, its preparation method and application. Background technique [0002] The field of percutaneous interventional therapy has made remarkable achievements since it was pioneered in the 1970s, from initial balloon expansion interventional therapy to subsequent stent implantation. Among them, the drug-loaded stents used in stent implantation have developed from bare metal stents to drug-eluting stents based on stainless steel, cobalt-chromium alloy, and platinum-chromium alloy, and then gradually appeared carrier-free drug-eluting stents, Degradable drug-carrier-coated drug-eluting stents are the mainstream second-generation drug-eluting stents, and people are moving towards safer and more effective treatments step by step. Until today, the technology of the second generation of drug-eluting stents has...

AI Technical Summary

Problems solved by technology

[0004] The main problems of the stent matrix prepared by the above method include: (1) The radial support force is too low to resist the blood flow in the human body, and it is easy to cause poor adherence of the stent or collapse of the stent wire, that is, it is unsafe to use (2) Due to the particularity of interventional therapy, it is difficult to deliver the stent to the narrow lesion, which is not practical

[0005] In addition, the preparation process of the above method is complicated and requires high-precision processing and manufacturing equipment, which in turn increases the processing and manufacturing cost of the bracket base, which does not conform to the principle of economic benefits

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