Bioabsorbable polymer scaffold matrix as well as preparation method and application thereof
A technology for absorbing polymers and biology, applied in stents, prostheses, medicines and other directions, can solve the problems of increasing the processing and manufacturing costs of stent bases, complicated preparation process steps, and inability to resist blood flow scouring, and is conducive to large-scale The effect of the production and promotion of the drug, the improvement of the drug load, and the improvement of the supporting force
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[0058] Example 1
[0059] (1) L-polylactic acid with a characteristic viscosity of 5.0dl / g is extruded into a tube with an outer diameter of 4.0mm and a wall thickness of 0.5mm with an extruder, and the tube is carved into a stent structure by a laser engraving method.
[0060] (2) Surface treatment of the engraved stent structure: laser etching is used to perforate the surface of the polymer stent structure. The size of the holes is 20 microns in diameter and 20 microns in depth to obtain a stent matrix without surface activation.
Example Embodiment
[0061] Example 2
[0062] (1) The polylactic acid-glycolic acid copolymer (polylactic acid:glycolic acid=85:15) with a characteristic viscosity of 2.00dl / g is molded into a pipe with an outer diameter of 3.0mm and a wall thickness of 0.3mm with an extruder, and laser engraving Method Carve the pipe into a support structure.
[0063] (2) Surface treatment of the carved stent structure: use chemical etching to place holes on the surface of the polymer stent structure, that is, immerse the stent structure in a 98% concentrated sulfuric acid solution, and use ultrasonic oscillation with an oscillation frequency of 30 kHz. It takes 10 minutes to place holes on the surface of the support structure. The size distribution range of the pore size is 1-50 microns in pore size and 1-50 microns in depth to obtain a non-surface activated scaffold matrix.
Example Embodiment
[0064] Example 3
[0065] (1) The polylactic acid-caprolactone copolymer (polylactic acid:polycaprolactone=50:50) with an intrinsic viscosity of 2.0dl / g is extruded into an outer diameter of 2.0mm and a wall thickness of 0.5mm. The tube is engraved into a support structure by laser engraving method.
[0066] (2) Surface treatment of the engraved stent structure: the surface of the polymer stent structure is punched with a pinhole processing method. The diameter of the punching needle is 30 microns, and the size of the surface hole is 30 microns in diameter and 30 microns in depth. The non-surface activated scaffold matrix.
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