Compound chlorhexidine acetate gel for treating livestock endometritis, and preparation method thereof

Abstract

The invention discloses a compound chlorhexidine acetate gel for treating livestock endometritis, and a preparation method thereof. The gel is prepared from the following materials by weight: 0.3-0.8% of chlorhexidine acetate, 0.5-1% of metronidazole, 0.6-1.2% of carbomer, 0.4-0.7% of pH regulator, 30-50% of organic solvent, 0.05-0.3% of solubilizer, 0.5-0.15% of preservative, and water. The preparation method comprises the steps of spreading carbomer to water surface in batches to avoid agglomeration, stirring, standing for 24-48 h, and adding the pH regulator to obtain matrix; mixing chlorhexidine acetate, metronidazole, organic solvent, solubilizer and preservative, and adding into the matrix; and supplementing water. The gel is adhered to mucous membrane through vaginal administration, and releases drugs in the gel slowly to prolong drug acting time, achieve high curative rate and significant curative effect, and finally realize treatment objective.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a gel for treating domestic animal endometritis and a preparation method thereof. Background technique [0002] Endometritis is a common multiple reproductive organ disease in large-scale pig farms and cattle farms. It is one of the main causes of infertility in livestock. The incidence rate of many large-scale pig farms is about 20%. It can be as high as more than 40%, and the incidence of cow endometritis is also quite serious, about 20% to 50%. As a commonly used disinfectant, chlorhexidine acetate has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Metronidazole has broad-spectrum anti-anaerobic and antiprotozoal effects, and is used for the prevention and treatment of anaerobic bacteria. Chlorhexidine acetate and metronidazole have different effects on different types of inflammation, so the main use is the synergist...

AI Technical Summary

Problems solved by technology

Due to the complexity of the uterine tissue of domestic animals, the uncertainty of the curative effect of intramuscular injection in the treatment of endometritis and the difficulty of systemic administration, antibiotic uterine perfusion therapy is often used for treatment in veterinary clinics, but drug resistance is prone to occur , increase the cost of treatment, and the operation is cumbersome. Frequent administration not only disturbs the life of the mother animal and causes damage, but also affects the lactation of the young animal.