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Human hair keratin shape righting material with adjustable and controllable mechanical property as well as preparation method thereof

A kind of keratin and autologous technology, applied in the direction of human tubular structure devices, blood vessels, muscles, etc., can solve the problems of increasing pain for patients, achieve the goal of avoiding pain, ensuring biocompatibility and safety of use, and improving elasticity and toughness Effect

Inactive Publication Date: 2012-12-26
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the matrix of such medical implants is often non-degradable and needs to be surgically removed after the completion of the orthopedic and rehabilitation treatment, which increases the pain of the patient. Therefore, biodegradable orthopedic implants should be further developed

Method used

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  • Human hair keratin shape righting material with adjustable and controllable mechanical property as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Cut the washed human hair into 3-5mm long fiber segments, and immerse it in a solution of 250ml potassium bisulfite and urea with a solid-liquid ratio of 3g / 100ml, wherein the solution is prepared by adding sodium metabisulfite to 7M Obtained from urea aqueous solution, the mass concentration of potassium bisulfite is 8%, the mixture is stirred at 60° C. for 5 h, and the rotation speed of the stirrer is 300 r / min. After filtering through an 80-mesh sieve, centrifuge at 4000rpm for 0.4h and take the supernatant. Under the condition of nitrogen protection, the filter module is used to quickly desalinate and remove low molecular weight salts in the solution, and then concentrate to obtain a keratin solution with a concentration of 3% by mass.

[0026] Slowly drop 0.01% aqueous hydrogen peroxide solution into the pure keratin solution at a mass percentage of 1:100, then cast the keratin solution into a sheet mold with a thickness of 1 mm, and solidify at a temperature of 50°...

Embodiment 2

[0028] Cut the washed human hair into 3-5mm long fiber segments, and immerse it in a solution of 250ml sodium metabisulfite and urea with a solid-liquid ratio of 1g / 100ml, wherein the solution is obtained by adding sodium metabisulfite to a 6M aqueous urea solution The mass concentration of sodium metabisulfite was 7%, and the mixture was stirred at 90° C. for 2 h, and the speed of the stirrer was 200 r / min. After filtering through a 120-mesh sieve, centrifuge at 7000rpm for 0.2h and take the supernatant. Under the condition of nitrogen protection, the filter module is used to quickly desalinate and remove low molecular weight salts in the solution, and then concentrate to obtain a keratin solution with a concentration of 2% by mass.

[0029] Slowly drop 0.02% aqueous hydrogen peroxide solution into the pure keratin solution at a ratio of 1:100 by mass, and then cast the keratin solution into a micro-pipe mold that simulates the size of blood vessels, at a temperature of 40°C ...

Embodiment 3

[0031]Cut the cleaned rat hair into 3-5mm long fiber segments, and immerse it in the solution of 250ml potassium sulfite and thiourea with a solid-liquid ratio of 4g / 100ml, wherein the solution is obtained by adding potassium sulfite to It was obtained from a 10M thiourea aqueous solution, the mass concentration of potassium sulfite was 12%, and the mixture was stirred at 50° C. for 4 hours, and the speed of the stirrer was 100 r / min. After filtering through a 100-mesh sieve, centrifuge at 3000rpm for 1 hour and take the supernatant. Under the condition of nitrogen protection, the filter module is used to quickly desalinate and remove low molecular weight salts in the solution, and then concentrate to obtain a keratin solution with a concentration of 5% by mass.

[0032] Aqueous hydrogen peroxide solution with a concentration of 0.04% is slowly dropped into the pure keratin solution at a mass percentage of 1:100, and then the keratin solution is cast in a long and thin mold wit...

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Abstract

The invention provides a human hair keratin shape righting material with adjustable and controllable mechanical property and a preparation method of the human hair keratin shape righting material. The human hair keratin shape righting material is prepared by a pure keratin solution obtained by treating human hairs or animal hairs by a reduction method; the obtained human hair keratin shape righting material is good in elasticity controllability and excellent in mechanical property; a controllable range of elastic elongation rate is 50-110%, the elastic recovery rate is 98-99%, the breakage strength is 0.5-0.7GPa, and the initial modulus is 0.1-0.75GPa; and requirements of elasticity and mechanical property for shape righting and repairing of loose connective tissues and different muscle body tissues such as blood vessels, ligaments and cartilage tissues can be met. The human hair keratin shape righting material is prepared by pure human hair keratin, can induce collagenous fiber regeneration, is good in biodegradability, can be fully degraded and absorbed by muscle bodies, does not cause tissue adhesion in the shape righting and repairing processes, and has a wide application prospect in the field of biological medicines.

Description

technical field [0001] The invention relates to an autologous keratin orthopedic material with adjustable mechanical properties and a preparation method thereof, belonging to the technical field of biomaterials. Background technique [0002] Exploiting the excellent biocompatibility of natural biomaterials to develop new bioorthopedic materials is an important research topic in the field of biomedical engineering and tissue engineering alternative therapy. The human or animal body is composed of a large amount of flexible and extremely elastic connective tissue. These connective tissues perform different functions in different organs or tissues to ensure the normal operation of the body. Collagen fibers are an important fiber that constitutes connective tissue, widely present in organs, skin, blood vessels, sclera, ligaments and tendons. In order to meet the needs of different tissue functions in the body, the structure of collagen fibers in different tissues is also differ...

Claims

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Application Information

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IPC IPC(8): A61L27/22C08H1/06A61F2/06A61F2/08A61F2/28
Inventor 范杰刘雍
Owner TIANJIN POLYTECHNIC UNIV
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