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Paederia scandens water extract, and preparation method and application thereof

A technology for water extracts and Phyllostachys chinensis, which is applied in the field of Phyllostachys chinensis water extracts, can solve the problems of high energy consumption, complicated operation and the like, and achieves the effects of high yield, simple process and good pharmacodynamic effect.

Active Publication Date: 2013-01-02
NINGBO DACHANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the method disclosed in this application is cumbersome to operate and has high energy consumption.

Method used

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  • Paederia scandens water extract, and preparation method and application thereof
  • Paederia scandens water extract, and preparation method and application thereof
  • Paederia scandens water extract, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] Take 1Kg of the herbal material of Jiyia vine (origin in Sichuan, batch number: 100101), process it into decoction pieces about 1cm long, put it in the extractor, add 8 times the amount of water, heat and reflux for extraction three times, the obtained extract is left to stand overnight, and the supernatant is concentrated D101 macroporous resin adsorption chromatography (resin pretreatment method: pre-soak with 95% ethanol overnight before use, and then gradually use high-concentration to low-concentration ethanol to transition to pure aqueous solution state, and then use aqueous solution Pack macroporous resin chromatography column), water, ethanol-containing amount is 10%, 30% and 50% solvent to carry out eluting respectively, collects the eluent of 10% and 30% combined part, the eluent of 50%, After drying under reduced pressure, 11.75 g (1003-2) of the 30% ethanol-eluted extract and 5.5 g (1003-3) of the 50% ethanol-eluted extract were obtained. The 30% ethanol elu...

Embodiment 2

[0051] Take 1Kg of the herbal material of Jiyatura (produced in Shandong, batch number: HP2010072018), process it into decoction pieces about 1cm long, put it in the extractor, add 10 times the amount of water, heat and reflux for three times, and concentrate the obtained extract to 1.5L, add 95% ethanol After reaching an alcohol content of 70%, let it stand overnight, take the supernatant and concentrate until it has no alcohol smell, and perform adsorption chromatography on the treated D101 macroporous resin, and elute with water, solvents containing 30% and 50% ethanol respectively , collected 30% and 50% eluents, and dried under reduced pressure to obtain 16.0 g (1003-4) of the 30% ethanol-eluted extract and 5.55 g (1003-5) of the 50% extract. The 30% ethanol elution extract of Gallus sagitta is analyzed by HPLC, wherein the content of methyl sagittidine is 0.015%; 19.90%; the content of chicken savine glucoside is 0.58%; the content of chicken savine glycoside methyl este...

Embodiment 3

[0053] Take 1Kg of Jiyao Teng medicinal material (origin: Yunnan; batch number: 20110617), process it into decoction pieces about 1cm long, put it in a 30L enamel tank, add 8 times the amount of water, heat and extract for 3 hours, add 6 times the amount of water, heat and extract for 3 hours , combine the two extracts, concentrate under reduced pressure to about 400ml, add 3 times the volume of 95% ethanol to about 70% alcohol content and let it stand overnight, take the supernatant and concentrate until it has no alcohol smell. Resin adsorption resin chromatography (resin pretreatment method: soak overnight with 95% ethanol containing 5% sodium hydroxide before use, then gradually use high-concentration to low-concentration ethanol to transition to a pure aqueous solution state, wash until neutral, and then Gradually use low-concentration to high-concentration ethanol to transition to 95% ethanol state, soak overnight in 95% ethanol containing 3% hydrochloric acid, then gradu...

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Abstract

The invention discloses a paederia scandens water extract containing an iridoid glycoside compound. The extract is characterized in that the iridoid glycoside compound contains 8.00-60.0% of paederosidie acid. The invention also discloses a preparation method of the paederia scandens water extract. The method comprises the steps that: (a) a paederia scandens material or decoction pieces are subjected to water extraction, such that an extraction liquid is obtained; (b) the extraction liquid is concentrated; methanol or ethanol is added, or the concentrated liquid is subjected to standing, and the liquid is precipitated; and a supernatant is obtained; (c) the supernatant is concentrated until no alcohol smell is left; the concentrated liquid is subjected to macroporous resin chromatography; elution is carried out sequentially by using water and ethanol of different concentrations; an eluant is collected; ethanol is recovered; and the eluant is subjected to reduced-pressure drying, such that the paederia scandens water extract is obtained; and (d) optionally, ethanol is added to the paederia scandens water extract obtained in the step (c), and filtering, concentrating, and drying are carried out. The paederia scandens water extract provided by the invention can be used for preparing medicines used for treating gout. The preparation method has simple processes, and is suitable for industrialized productions.

Description

technical field [0001] The present invention relates to the water extract of vine vine, its preparation method and application. Background technique [0002] Chicken Yateng is the above-ground part or whole plant of Rubiaceae Paederia scandens (Lour.) Merr. It is a traditional Chinese herbal medicine, also known as chicken shit rattan, cowhide jelly, Jieshu rattan, bullshit rattan, smelly rattan, breeze Rattan, etc., Cercis japonica tastes glucoside, flat in nature, enters the liver, stomach, and large intestine meridians, and has the effects of eliminating food accumulation, dispelling wind and activating blood circulation, relieving pain and reducing swelling. Distributed in many countries in China and Southeast Asia, domestic and foreign studies on the pharmacological effects and clinical application of Gallus vine mainly focus on anti-inflammatory, analgesic and treatment of digestive system diseases. In recent years, the chemical composition studies have shown that Sag...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K31/7048A61P19/06
Inventor 吴彤沈幸光李燕沈龙海王鑫杰周海凤缪刘萍张乐乐安泳潼尹蓓珮庄昌龙
Owner NINGBO DACHANG PHARMA
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