Method for preparing abamectin microcapsules by complex coacervation

A compound coacervation method and technology of avermectin, applied in the field of microcapsule preparation, can solve the problems of high price, few studies on composite wall materials, dependence on imports of gum arabic, etc., so as to improve the duration of efficacy, reduce environmental pollution, broaden the The effect of the application path

Active Publication Date: 2013-01-30
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, gelatin and gum arabic are mostly used as wall materials in the composite coacervation method, and there a...

Method used

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  • Method for preparing abamectin microcapsules by complex coacervation
  • Method for preparing abamectin microcapsules by complex coacervation
  • Method for preparing abamectin microcapsules by complex coacervation

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preparation example Construction

[0033] (2) Preparation of Abamectin Solution: Dissolve Abamectin in the form of powder or granules at room temperature in a solvent. The solvent is xylene to ethyl acetate with a mass ratio of 1:2~2 : 1 compound solvent, 2.0~3.0g of this solvent is needed to dissolve 1g of Abamectin;

[0034] (3) Accurately weigh the abamectin solution according to the ratio of the mass ratio of the abamectin solution to the wall material of 1:1~3:1, and add it to the wall material solution, at 10000~15000r / min High-speed dispersion and homogenization for 2-5 minutes to obtain a uniform emulsion;

[0035] (4) Add 10% acetic acid to adjust the pH to 4.4~4.8 under the condition of stirring at a temperature of 40~50°C and a rotation speed of 400~600r / min, and react for 5~10 minutes;

[0036] (5) Cool in an ice bath, at 15°C, the cooling time is 20-40 minutes, adjust the pH to 9.0-10.0, add glutaraldehyde 0.1g / g gelatin, and solidify at room temperature for 2-5 hours;

[0037] (6) Filtration and...

Embodiment 1

[0047] Preparation of Abamectin Solution: Dissolve Avermectin that is powdery or granular at normal temperature in a solvent, and the solvent is xylene and ethyl acetate with a mass ratio of 1:2 to 2:1. Compound solvent, 2.0~3.0g of the solvent is needed to dissolve 1g of Abamectin.

[0048] Weigh 4.8g of gelatin and 0.6g of sodium alginate powder, add 600g of deionized water, stir and dissolve in a 60°C water bath. Weigh 5.4g of abamectin solution, add dropwise while dispersing at high speed, the rotating speed is 15000r / min, and disperse for 2min. The mixed solution was placed at a constant temperature of 45°C and a rotational speed of 400r / min, and 10% acetic acid was added dropwise to adjust the pH to 4.6, and the composite coagulation reaction was carried out for 8 minutes. Slowly lower the temperature to below 15°C, condition the pH to 9.0, add glutaraldehyde curing agent, the dosage is 1 / 4 of the gelatin mass. Cured at room temperature for 3h.

[0049] The microcapsu...

Embodiment 2

[0051]Weigh 4.8g of gelatin and 0.6g of sodium alginate powder, add 600g of deionized water, stir and dissolve in a 60°C water bath. Weigh 5.4g of abamectin solution, add dropwise while dispersing at high speed, the rotating speed is 15000r / min, and disperse for 2min. The mixed solution was placed at a constant temperature of 45°C and a rotational speed of 400r / min, and 10% acetic acid was added dropwise to adjust the pH to 4.4, and the composite coagulation reaction was carried out for 8 minutes. Slowly lower the temperature to below 15°C, condition the pH to 9.0, add glutaraldehyde curing agent, the dosage is 1 / 4 of the gelatin mass. Cured at room temperature for 3h.

[0052] Using the methanol solvent extraction method, the microencapsulation yield was 76.23% and the efficiency was 72.43% measured by ultraviolet spectrophotometry. The yield of microencapsulation decreased when the gelatin / sodium alginate deviated from the optimal pH condition. The average particle size o...

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Abstract

The invention relates to a method for preparing abamectin microcapsules by complex coacervation, belonging to the technical field of preparation of microcapsules. The invention aims to provide a preparation method of novel abamectin microcapsules. The method comprises the following steps: taking sodium alginate as wall materials instead of combination of Arabic gums and gelatins and preparing the novel abamectin microcapsules by water bath solution, high-speed cutting and dispersing, acid regulating, cooling, reducing, solidifying and drying. The method has the advantages of low cost, small pollution, good film-forming property and so on; microencapsulation products have the embedding rate not less than 85%, the drug loading capacity not less than 75%, the lasting period increased by 3-8 times and the retention rate more than 70% after storing at room temperature for three months; the method effectively control the slow release effect of abamectins while improving the light stability of the abamectins and achieves the purposes of reducing the dosing frequency, the dosage and the cost and increasing a control effect.

Description

technical field [0001] The invention relates to a method for preparing pesticide abamectin microcapsules by a composite coacervation method, and belongs to the technical field of microcapsule preparation. Background technique [0002] Abamectin is one of the most promising biopesticides at present. In practical application, the main dosage form of abamectin is emulsifiable concentrate, which has poor stability, and due to the strong photolysis of abamectin and short residual effect period, the release time and duration of its emulsifiable concentrate are short, which seriously affects the Insecticidal effect, and serious environmental pollution. Therefore, how to prolong the release time and duration of drug effect of abamectin has become a key issue in the application research of abamectin. [0003] Abamectin microencapsulation can effectively solve the above problems. According to reports, the main methods for preparing avermectin microcapsules are interfacial polymeriz...

Claims

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Application Information

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IPC IPC(8): A01N25/28A01N43/90A01P7/04B01J13/10
Inventor 于秋生陈正行冯镇泰冯伟周小敏
Owner JIANGNAN UNIV
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