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Mesoporous bioactive glass material with apatite nanocrystallines and method for producing mesoporous bioactive glass material with apatite nanocrystallines

A bioactive glass and apatite technology, applied in the field of biomaterials, can solve the problems of uncontrollable and time-consuming apatite nanocrystals, and achieve the effects of simple operation, simple raw materials, and mild reaction conditions

Inactive Publication Date: 2013-02-13
ZHEJIANG SCI-TECH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method of self-assembly by solvent volatilization takes a long time, usually about 12 days, and the synthesized apatite nanocrystals are not controllable.

Method used

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  • Mesoporous bioactive glass material with apatite nanocrystallines and method for producing mesoporous bioactive glass material with apatite nanocrystallines
  • Mesoporous bioactive glass material with apatite nanocrystallines and method for producing mesoporous bioactive glass material with apatite nanocrystallines
  • Mesoporous bioactive glass material with apatite nanocrystallines and method for producing mesoporous bioactive glass material with apatite nanocrystallines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Using sucrose as raw material to prepare carbon spheres to synthesize mesoporous bioactive glass M60S-1C containing hydroxyapatite nanocrystals

[0043] Dissolve 60 grams of sucrose in 200 ml of ultra-pure water to form a clear solution, transfer it to a 250 ml hydrothermal kettle, seal it, heat it at 140°C for 36 hours, filter it with suction, wash it with deionized water and ethanol, and dry it That is, carbon sphere powder. The resulting carbon spheres are 200 nanometers to 1 micron through electron microscope inspection, see figure 1 .

[0044] Dissolve 2 g of cetyltrimethylammonium bromide (CTAB) in 100 ml of deionized water, adjust the pH value of the solution below 2 with nitric acid, and stir until clear at 30°C. According to the molar ratio of silicon dioxide: calcium oxide: phosphorus pentoxide is 60:36:4, add 5.62 grams of ethyl orthosilicate, 1.64 grams of triethyl phosphate, 1.80 grams of calcium chloride, according to calcium chloride: carbon ...

Embodiment 2

[0045] Example 2: Using sucrose as raw material to prepare carbon spheres to synthesize mesoporous bioactive glass M80S-2C containing hydroxyapatite nanocrystals

[0046] Prepare carbon sphere powder and structure directing agent solution according to the steps and raw material ratio of Example 1. According to silicon dioxide: calcium oxide: the mol ratio of phosphorus pentoxide is 80:15:5, add 7.49 gram tetraethyl orthosilicate, 0.82 gram triethyl phosphate, 0.56 gram calcium chloride, 1.11 gram carbon sphere powder ( Calcium chloride: carbon sphere mass ratio is 1:2), stirred at 50°C for 72 hours, dried at 90°C and calcined at 650°C for 6 hours to obtain mesoporous bioactive glass M80S containing hydroxyapatite nanocrystals -2C.

Embodiment 3

[0047] Example 3: Using sucrose as raw material to prepare carbon spheres to synthesize mesoporous bioactive glass M80S-10C containing hydroxyapatite nanocrystals

[0048] Prepare carbon sphere powder and precursor solution according to the steps and raw material ratio of Example 2. Add 7.49 grams of ethyl orthosilicate, 0.82 grams of triethyl phosphate, 1.60 grams of calcium nitrate, add 15.92 grams of carbon sphere powder according to the mass ratio of calcium nitrate:carbon spheres of 1:10, stir at 80°C for 96 hours, and dry at 110°C After that, it was calcined at 700° C. for 5 hours to obtain the mesoporous bioactive glass M80S-10C containing hydroxyapatite nanocrystals.

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Abstract

The invention relates to an ordered mesoporous bioactive glass material with apatite nanocrystallines and a method for producing the ordered mesoporous bioactive glass material with apatite nanocrystallines. The molar ratio of the main ingredients of the mesoporous bioactive glass material is that silicon dioxide to calcium oxide to phosphoric anhydride is (60-90):(6-36):(4-5), and an apatite nanocrystalline structure is a nanocrystal with nanopore clustered hydroxyapatite. The material adopts a double-template technology, carbon microspheres are taken as hard templates, a structure-directing agent is taken as a mesoporous template, and a sol-gel method is combined so as to synthesize the material under moderate conditions. The components of the novel mesoporous bioactive glass can be adjusted, a mesostructure is ordered and controllable, the pore diameter can be controlled within the range between 2 nanometers and 20 nanometers, the specific surface area can reach 600square meters / gram, and the pore volume can reach 0.8cubic centimeter / gram. The ordered mesoporous bioactive glass material can be used a support material for bone substituent or repair materials, drug release and tissue engineering.

Description

technical field [0001] The invention relates to a biological material, in particular to an ordered mesoporous bioactive glass material with apatite nanocrystals and a preparation method thereof. Background technique [0002] In 1991, Kesge and Beck of Mobil Company successfully synthesized a new M41S series silica (aluminum)-based ordered mesoporous molecular sieve material with adjustable pore size in the range of 1.5-10 nanometers. The emergence of the M41S series of mesoporous silicon-based materials officially opened the prelude to the development of mesoporous materials in the history of molecular sieve science. Due to the advantages of uniform and adjustable pore size, large specific surface area and pore volume, these materials have shown broad application prospects in the fields of catalysts, adsorbents, chemical sensors, biomedicine, and environmental protection. Especially in the field of biomedicine, mesoporous silicon-based materials with nanostructures, as a ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C3/097C03C4/00C03B8/02
Inventor 刘涛冯新星陈建勇赖冬志朱海霖
Owner ZHEJIANG SCI-TECH UNIV
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