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Preparation method of inorganic core-shell type quercetin molecularly imprinted polymer microsphere

A technology of molecular imprinting and quercetin, applied in microsphere preparation, inorganic chemistry, microcapsule preparation, etc., can solve the problems of trace analysis error, easy swelling, material waste, etc., and achieve simple preparation conditions and high mechanical strength. , Universal effect

Inactive Publication Date: 2013-04-24
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1) The controllability of the pulverization process is poor, and some irregular particles are inevitably produced during the pulverization process, and some action sites are destroyed at the same time
The yield of qualified particles obtained after screening is generally low, resulting in waste of materials
[0008] 2) Since the highly cross-linked polymer network is prepared, it is difficult to elute the internal template molecules
Residual template molecules desorb slowly during use, which brings large errors to applications such as trace analysis
[0009] 3) The distribution of binding sites in the polymer is uneven, and some sites are embedded in the body of the polymer, making it difficult for the target molecule to approach the binding site, and the binding rate is slow, thereby reducing the utilization rate of the imprinted site
[0010] 4) High molecular polymers have low mechanical strength and are prone to swelling, which changes the shape of holes and recognition sites

Method used

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  • Preparation method of inorganic core-shell type quercetin molecularly imprinted polymer microsphere
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  • Preparation method of inorganic core-shell type quercetin molecularly imprinted polymer microsphere

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Experimental program
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Effect test

Embodiment 1

[0036] Heat 5 g of spherical porous silica gel in concentrated hydrochloric acid to reflux for 8 hours, then wash with distilled water until neutral, and dry to obtain activated silica gel;

[0037] 6 mmol of aminopropyltriethoxysilane, 18 mmol of tetraethoxysilane and 2 mmol of quercetin were added to 30 mL of methanol solution. Stir well, add 1.0 g of activated silica gel and 1.0 mL of 10% (v / v) acetic acid aqueous solution, and reflux for 15 hours; after the reaction is completed, filter the product and dry to obtain a molecularly imprinted polymer containing quercetin;

[0038] Put the dried product from the previous step into a Soxhlet extractor, and repeatedly extract with a mixed solution of ammonia, water and methanol until the effluent from the Soxhlet extractor does not contain quercetin. The dried product is the inorganic core-shell molecularly imprinted polymer.

Embodiment 2

[0040] Heat 3g of porous silica gel under reflux in concentrated hydrochloric acid for 6h, then wash with distilled water until neutral, and dry to obtain activated silica gel;

[0041] 3 mmol of aminopropyltriethoxysilane, 9 mmol of tetraethoxysilane and 1 mmol of quercetin were added to 15 mL of methanol solution. Stir well, add 0.5g of activated silica gel and 0.5mL of acetic acid / water solution with a concentration of 10% (v / v), and reflux for 12 hours; filter the product after the reaction, and dry it to obtain a molecularly imprinted polymer containing quercetin;

[0042] Put the dried product from the previous step into a Soxhlet extractor, and use a mixed solution of ammonia, water and methanol to extract repeatedly until the solution flowing down from the Soxhlet extractor is free of quercetin. The dried product is the inorganic core-shell molecularly imprinted polymer.

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Abstract

The invention discloses a preparation method of an inorganic core-shell type quercetin molecularly imprinted polymer microsphere. The method comprises: first subjecting a functional monomer, a crosslinking agent and a template molecule to self-assembly on a silica gel ball surface, then leaving a sol-gel reaction to occur so as to form an inorganic polymer film on the silica gel ball surface, and finally removing residual quercetin molecules from the product, thus obtaining a molecularly imprinted polymer of quercetin. Static adsorption curves, adsorption isotherms and competitive adsorption experiments show that the polymer has a fast selective adsorption ability on quercetin.

Description

technical field [0001] The invention belongs to a preparation method of inorganic core-shell type quercetin molecularly imprinted polymer microspheres. Background technique [0002] Quercetin is a natural flavonoid compound, which has anti-tumor, anti-platelet aggregation, anti-oxidation, cardiovascular protection and anti-virus effects (J.Agric.Food Chem., 51(2003), 6445). Pharmacological tests show that it is the main active ingredient of various traditional Chinese medicines such as arborvitae leaves, Panax notoginseng, ginkgo, etc. On the one hand, the separation and extraction of quercetin can provide a reference for subsequent industrial production, and on the other hand, it can be used as a pretreatment method for the analysis of quercetin in traditional Chinese medicine. [0003] Currently extracting quercetin from traditional Chinese medicine mainly adopts two steps, one is the extraction of total flavonoids; the other is the preparation and purification of quercet...

Claims

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Application Information

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IPC IPC(8): B01J20/285B01J20/30B01J20/28B01J13/14
Inventor 蒋生祥杨鹏邱洪灯
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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