Synergistic sulfamethoxypyridazine injection for livestock

A technology of sulfamethoxypyridazine and injection, which is applied in the field of veterinary compound sulfamethoxypyridazine injection and its preparation, can solve the problems of unsatisfactory treatment effect, short residence time, strong irritation, etc., and improve product quality. Added value, less usage, less irritating effect

Inactive Publication Date: 2013-05-08
金河牧星(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical manifestations of these diseases are infectious, high fever and inflammation. The treatment effect of compound sulfamethoxypyridazine injection recorded in the Pharmacopoeia is not ideal, and it is usually inj

Method used

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  • Synergistic sulfamethoxypyridazine injection for livestock
  • Synergistic sulfamethoxypyridazine injection for livestock
  • Synergistic sulfamethoxypyridazine injection for livestock

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0031] Example 1

[0032] 1. Formula

[0033] Sulfamethoxypyridazine: 10g, trimethoprim: 2g, indomethacin: 2g, sodium thiosulfate: 0.1g, polyethylene glycol 8000: 5g, propylene glycol 30ml, 10ml of 1mol / L hydroxide Sodium solution and 0.5 mol / L hydrochloric acid each for use, 55ml water for injection.

[0034] 2: Preparation method

[0035] In the first step, take the water for injection and heat it to 50-60℃, add sodium thiosulfate and polyethylene glycol 8000 respectively, stir to dissolve them, adjust the pH value to about 10 with sodium hydroxide solution, and prepare liquid A for later use ;

[0036] In the second step, take propylene glycol, heat it to 60-70°C, add sulfamethoxidazine, trimethoprim, and indomethacin respectively, stir to dissolve all of them, and prepare liquid B;

[0037] In the third step, add liquid A to liquid B and stir evenly, continue to stir for 30 minutes, adjust the pH to 9.5-10.5; first filter with a 0.45 micron organic filter membrane, and then filter ...

Example Embodiment

[0039] Example 2

[0040] 1. Formula

[0041] Sulfamethoxypyridazine: 15g, trimethoprim: 3g, indomethacin: 3g, sodium thiosulfate: 0.15g, polyethylene glycol 8000: 7.5g, propylene glycol 35ml, 10ml hydrogen with a concentration of 1mol / L Sodium oxide solution and 0.5 mol / L hydrochloric acid each for use, and 50 ml of water for injection.

[0042] 2: Preparation method

[0043] In the first step, take the water for injection and heat it to 50-60℃, add sodium thiosulfate and polyethylene glycol 8000 respectively, stir to dissolve them, adjust the pH value to about 10 with sodium hydroxide solution, and prepare liquid A for later use ;

[0044] In the second step, take propylene glycol, heat it to 60-70°C, add sulfamethoxazine, trimethoprim, and indomethacin respectively, stir to dissolve all of them, and prepare liquid B;

[0045] In the third step, add liquid A to liquid B and stir evenly, continue to stir for 30 minutes, and adjust the pH to 9.5-10.5. First filter with an organic filt...

Example Embodiment

[0047] Example 3

[0048] 1. Formula

[0049] Sulfamethoxypyridazine: 15g, trimethoprim: 3g, indomethacin: 3g, sodium bisulfite: 0.15g, polyethylene glycol 8000: 7.5g, propylene glycol 30ml, 10ml hydrogen with a concentration of 1mol / L Sodium oxide solution and 0.5 mol / L hydrochloric acid each for use, and 55 ml of water for injection.

[0050] 2: Preparation method

[0051] In the first step, take water for injection and heat it to 50-60°C, add sodium bisulfite and polyethylene glycol 8000 respectively, stir to dissolve them, adjust the pH to 9.5, and prepare liquid A for later use;

[0052] In the second step, take propylene glycol, heat it to 60-70°C, add sulfamethoxazine, trimethoprim, and indomethacin respectively, stir to dissolve all of them, and prepare liquid B;

[0053] In the third step, add liquid A to liquid B and stir evenly, continue to stir for 30 minutes, and adjust the pH to 9.5-10.5. First filter with an organic filter membrane with a diameter of 0.45 microns, and th...

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Abstract

The invention relates to a compound sulfamethoxypyridazine injection and a preparation method thereof. The synergistic sulfamethoxypyridazine injection has enduring drug effect and obvious curative effect. The injection comprises the following components in parts by weight: 10-20 parts of sulfamethoxypyridazine, 2-4 parts of indometacin, 2-4 parts of trimethoprim, 5-10 parts of polyethyleneglycol 8000, 30-40 parts of propanediol, 0.1-0.2 part of antioxidant, 30-55 parts of water for injection, and sufficient amount of pH regulator for regulating the pH value of the system to 9.5-10.5. The preparation method comprises the following steps: adding the antioxidant into the water for injection to prepare a solution A, adding the polyethyleneglycol 8000, sulfamethoxypyridazine, indometacin and trimethoprim into the propanediol, and completely dissolving by stirring to prepare a solution B; and merging, filtering, packaging and sterilizing to obtain the finished product. The injection provided by the invention is a new drug preparation with triple effects, and has the advantages of long drug effect, low consumption, low application frequency, small irritation, quick drug effect taking and wide curative range.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a veterinary compound sulfamethoxypyridazine injection and a preparation method thereof. Background technique [0002] Sulfonamides have been used clinically for decades. Sulfamethoxypyridazine (SMP) is one of the main varieties of sulfonamides and is effective against most Gram-positive bacteria and some Gram-negative bacteria. , especially Streptococcus, Staphylococcus, Pneumococcus, Escherichia coli, Listeria and other sensitive bacteria infection, also effective for Chlamydia and some protozoa, it is a broad-spectrum antibacterial agent. The maintenance time of effective plasma concentration is 24 hours for buffaloes, 5.8 hours for pigs, 7 hours for goats and 2 hours for sheep. This product is suitable for systemic infection caused by various animal sensitive bacteria. It has definite curative effect, stable properties, easy to use, cheap price and convenient long-term storage. It is th...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K31/405A61K31/505A61K9/08A61P31/04A61P33/02A61P11/06A61P29/00
Inventor 胡学全秦斌
Owner 金河牧星(重庆)生物科技有限公司
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