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Preparation method for temperature-sensitive chitosan-based polyelectrolyte composite micelle

A technology of chitosan-based polymeric and composite micelles, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulas, emulsion delivery, etc., can solve the problems such as the inability to achieve controlled release of drug loading, and achieve controllable loading and release, uniform size distribution, simple and easy preparation method

Inactive Publication Date: 2013-07-17
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of polyelectrolyte complex micelles is used as a drug carrier, and the controlled release of the drug cannot be achieved

Method used

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  • Preparation method for temperature-sensitive chitosan-based polyelectrolyte composite micelle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Dissolve 0.6g of chitosan in 40mL of 5% acetic acid solution. After fully dissolving, add 0.5g of N-isopropylacrylamide, stir and mix well; vacuumize, blow nitrogen, and add the initiator under the protection of nitrogen (0.1 g of ammonium cerium nitrate was dissolved in 10 mL of distilled water), the temperature was raised to 40° C., and the reaction was carried out for 4 hours under constant stirring. The reaction solution was poured into acetone to precipitate, and the crude product was obtained by suction filtration, then extracted with methanol for 24 hours to remove the homopolymer, and dried in a vacuum oven to obtain chitosan-grafted poly-N-isopropylacrylamide copolymer. Sodium carboxymethyl cellulose and chitosan-grafted poly-N-isopropylacrylamide were dissolved in distilled water with a pH value of 5.0 to form a solution with an equal mass concentration of 0.5 mg / mL. Under stirring conditions, Slowly add the graft copolymer solution into the sodium carboxymeth...

Embodiment 2

[0021] Dissolve 0.6g of chitosan in 40mL of 4% acetic acid solution. After fully dissolving, add 1.0g of N-isopropylacrylamide, stir and mix well; vacuumize, blow nitrogen, and add the initiator under the protection of nitrogen (0.1g of potassium persulfate dissolved in 10mL of distilled water), heated up to 60°C, and reacted for 8 hours under constant stirring. Pour the reaction solution into acetone to precipitate, filter with suction to obtain the crude product, then extract with methanol for 36 hours to remove the homopolymer, and dry in a vacuum oven to obtain a copolymer of chitosan grafted poly-N-isopropylacrylamide . Dissolve sodium alginate and chitosan-grafted poly-N-isopropylacrylamide in distilled water with a pH value of 6.0, respectively, to form a solution with a mass concentration of 1 mg / mL. Under stirring conditions, the mass ratio is 3: 7. Slowly add the graft copolymer solution into the sodium alginate solution, and continue stirring for 24 hours to obtain...

Embodiment 3

[0024] Dissolve 0.6g of chitosan in 40mL of 10% acetic acid solution. After fully dissolving, add 2.0g of N-isopropylacrylamide, stir and mix well; vacuumize, blow nitrogen, and add the initiator under the protection of nitrogen (0.1 g of potassium persulfate dissolved in 10 mL of distilled water), heated to 65° C., and reacted for 8 hours under uniform magnetic stirring. Pour the reaction solution into acetone to precipitate, filter with suction to obtain the crude product, then extract with methanol for 48 hours to remove the homopolymer, dry in a vacuum oven to obtain a copolymer of chitosan grafted poly-N-isopropylacrylamide . Sodium alginate and the synthesized graft copolymer were respectively dissolved in distilled water with a pH value of 6.0 to prepare a solution with a mass concentration of 1 mg / mL. Under stirring conditions, the graft copolymer solution was mixed in a mass ratio of 4:6 slowly added into the sodium alginate solution, and continued to stir for 24 hou...

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Abstract

The invention discloses a preparation method for a temperature-sensitive chitosan-based polyelectrolyte composite micelle. The preparation method comprises the following concrete steps: dissolving chitosan in an acetic acid solution, adding a temperature-sensitive monomer N-isopropylacrylamide under stirring, adding a water-soluble initiator under the protection of nitrogen, carrying out a reaction for 4 to 12 h at a certain temperature, subjecting a reaction solution to acetone precipitation and pumping filtration and carrying out drying so as to obtain chitosan-grafted poly(N-isopropylacrylamide); and dissolving the synthesized graft copolymer in distilled water with a certain pH value, adding a certain proportion of an anionic polyelectrolyte solution under stirring and carrying out a reaction for 12 to 48 h. The temperature-sensitive chitosan-based polyelectrolyte composite micelle prepared in the invention has good biocompatibility, temperature sensitivity and stability performance and uniform particle size distribution; the preparation method is simple, and reaction conditions are mild; and the temperature-sensitive chitosan-based polyelectrolyte composite micelle has a potential application value in fields like drug delivery, micro-reactors and biosensors and is especially applicable to controllable loading and releasing of drugs.

Description

technical field [0001] The invention relates to a temperature-sensitive polymer material, specifically introduces a preparation method of a temperature-sensitive chitosan-based polyelectrolyte composite micelle, and belongs to the field of functional polymer materials. Background technique [0002] Polyelectrolyte complex (PEC) micelles are a type of polymer micelles formed by electrostatic interaction of two oppositely charged hydrophilic copolymers. Among them, the oppositely charged polyelectrolyte chain segments form the core of the composite micelle through electrostatic interaction, and the uncharged hydrophilic chain segments extend outside to form the outer shell of the micelles. Polyelectrolyte composite micelles prepared by self-assembly method are new polymer composite materials developed in recent years. , catalyst preparation and other fields have potential applications. In addition to the characteristics of traditional polymer micelles, polyelectrolyte comple...

Claims

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Application Information

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IPC IPC(8): C08L51/02C08L1/28C08L5/04C08L5/06C08J3/03C08F251/00C08F220/54A61K47/36A61K9/107
Inventor 李桂英张停郭磊刘军深
Owner LUDONG UNIVERSITY
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