Preparation method and application of amphiphatic copolymer modified chitosan compound

Abstract

The invention discloses a preparation method of amphiphatic copolymer modified chitosan compound. The method comprises the following steps: firstly using a mixture of lactic acid and L-malic acid as initial raw materials to directly prepare polylactic acid and malic acid oligomer by polycondensation, and preparing a series of copolymers in different hydrophilic degrees by changing the proportion of the lactic acid and L-malic acid (respectively as 1:1, 1:2, 1:3, 1:5, 1:8 and 1:10), respectively compounding the copolymers with different components with the water-soluble chitosan in mixing to obtain various compounds with different components; adding 0.8-2.4% of polyethylene glycol diglycidyl ether in the compound solution as the crosslinking agent, reacting for 6 hours at 70 DEG C in the water solution, and crosslinking the chitson in the compound to prepare the compound hydrogel; meanwhile, selecting the compound with low crosslinking degree to tiling on a glass plate, drying at 45 DEG C to form the film. The gel and the film can be used as a drug sustained release carrier, a wound dressing and a medical abherent.

Description

technical field [0001] This research involves the synthesis of an amphiphilic copolymer of lactic acid and malic acid and the preparation of its chitosan complex, which belongs to the technical field of biomedical materials. Background technique [0002] Chitosan is the deacetylation product of chitin, which can enhance the phagocytosis of macrophages and promote wound healing. It is a medical material with excellent performance and great development potential. Chitosan gel as a wound dressing to treat skin defects has the following effects: (1) antibacterial function, which can promote wound healing and reduce the formation of scars; (2) hemostatic effect. Hemostasis can also prevent the formation of fibrin bundles. (3) Biological barrier effect. Chitosan hydrogel is used as an anti-adhesive agent after surgery, which has the effect of isolating the wound surface and antibacterial effect, and can effectively prevent the adhesion of the wound surface and avoid secondary op...

AI Technical Summary

Problems solved by technology

[0003] The hydrogel prepared by single-component chitosan has high fluidity and insufficient mechanical strength at low cross-linking degree, which affects the performance

The film prepared by single-component chitosan is brittle, and the biodegradation cycle is too long, which is not good for excretion from the body

The cross-linking agents used in the preparation of chitosan gels generally include glutaraldehyde, formaldehyde, epichlorohydrin, etc. These cross-linking agent molecules have varying degrees of toxicity, and the residues in the gel cannot be removed, which increases the potential of the product. dangerous

Excessive glutaraldehyde content will increase the cytotoxicity of the gel, deepen the color and make the gel brittle and hard, which is not conducive to the adhesion and extension of the wound surface

And too low glutaraldehyde content will lead to insufficient cross-linking degree and affect the use effect

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