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Preparation method for ferulic acid

A technology for ferulic acid and cellulosic raw materials, applied in the preparation of organic compounds, chemical instruments and methods, preparation of oxygenated compounds, etc., to achieve mild conditions, reduced costs and pollution, and high purity.

Active Publication Date: 2013-09-25
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the feed liquid of preparation is sepia and contains more impurities, so purification becomes the bottleneck of preparing ferulic acid from cellulose, the key of the present invention is to solve its purification problem

Method used

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  • Preparation method for ferulic acid
  • Preparation method for ferulic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: utilize corn bran to prepare ferulic acid

[0036] (1) Pretreatment of raw materials:

[0037] Take a certain amount of corn husks, dry them at 105°C until the water content is 5%, grind them through a 40-mesh sieve with a grinder, and obtain the pretreated raw materials.

[0038] (2) Alkali alcohol treatment to obtain crude ferulic acid:

[0039] The raw material pretreated in step (1) is mixed with a solid-to-liquid ratio of 1 kg: 10 liters and a 2:50:50 (w / v / v) aqueous alkali alcohol solution (a mixed solution of sodium hydroxide: ethanol: water), 80 Extract at ℃ for 2.5 hours, centrifuge and filter in a three-legged centrifuge, and the filter residue can be used to prepare oligosaccharides;

[0040] The obtained filtrate is subjected to ultrafiltration with a membrane with a molecular weight cut-off of 5000 to further remove soluble macromolecular substances, and the permeate is used for future use.

[0041] (3) Obtaining ferulic acid:

[0042] The...

Embodiment 2

[0043] Embodiment 2: utilize wheat bran to prepare ferulic acid

[0044] (1) Pretreatment of raw materials:

[0045] Take a certain amount of wheat bran, dry it at 105°C to a water content of 2%, and pulverize it with a pulverizer (the degree of pulverization is 60 mesh) to obtain the pretreated raw material.

[0046] (2) Alkali alcohol treatment to obtain crude ferulic acid:

[0047] The raw material pretreated in step (1) is mixed with a solid-to-liquid ratio of 1 kg: 15 liters and a 3:60:40 (w / v / v) aqueous alkali alcohol solution (mixed solution of potassium hydroxide: ethanol: water), 60 Extract at ℃ for 4 hours and centrifuge in a three-legged centrifuge.

[0048] The centrifugate is further removed by ultrafiltration equipment with a membrane molecular weight cut-off of 10,000 and 2,000, and the permeate is used for standby.

[0049] (3) Obtaining high-purity ferulic acid:

[0050] The permeate in step (2) is subjected to nanofiltration treatment. The treatment step...

Embodiment 3

[0051] Embodiment 3: utilize bagasse to prepare ferulic acid

[0052] (1) Pretreatment of raw materials:

[0053] Take a certain amount of bagasse and grind it through a pulverizer (the degree of crushing is 20 mesh), and then dry it at 105°C until the water content is 5%.

[0054] (2) Alkali alcohol treatment to obtain crude ferulic acid:

[0055]The raw material pretreated in step (1) is mixed with a solid-to-liquid ratio of 1 kg: 12 liters and a 4:70:30 (w / v / v) alkali alcohol aqueous solution (sodium hydroxide: ethanol: water mixed solution), continuously Stir, extract at 40°C for 7 hours, and centrifuge in a three-legged centrifuge.

[0056] The centrifugate is further removed by ultrafiltration equipment with a membrane molecular weight cut-off of 20,000 and 1,000, and the permeate is used for standby.

[0057] (3) Obtaining ferulic acid:

[0058] The permeate in step (2) is subjected to nanofiltration treatment. The treatment steps of the permeate with nanofiltratio...

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Abstract

The invention discloses a preparation method for ferulic acid, and belongs to the field of separating extract from plants. The preparation method for the ferulic acid comprises following steps: extracting an alkaline hydrolysis liquid containing ferulic acid from fiber raw materials by using a mixed solution comprising alkali, alcohol and water, removing soluble macro-molecule impurity by ultra-filtration, concentrating the ultra-filtered permeate liquid by nano-filtration, acidifying the concentrated liquid, and allowing the acidized liquid to stand for crystallization at low temperature to obtain the ferulic acid product or extracting the ferulic acid product from the acidized liquid by an organic solvent. Solid wastes from agriculture and food processing are employed as raw materials in the method provided by the invention. According to the method, the ferulic acid, a high efficiency functional anti-oxidant, is produced. The ferulic acid is applicable to food industry, medicine industry and cosmetic industry, thereby bringing great economy significance and social significance.

Description

technical field [0001] The invention belongs to the field of separating extracts from plants, in particular to a preparation method of ferulic acid. Background technique [0002] Ferulic acid is a high-efficiency functional antioxidant with anti-thrombosis, prevention of atherosclerosis and heart disease, improvement of sperm motility, anti-bacterial and anti-inflammatory functions. Ferulic acid is widely used in medicine, food, cosmetics and other fields. [0003] Ferulic acid can be obtained by degrading plant cell wall materials with dilute alkali or ferulic esterase, because ferulic acid is mainly cross-linked with cell wall polysaccharides and lignin through ester bonds in plants, thus forming part of the cell wall. [0004] my country is a big producer of grain and sugarcane. The output of wheat and rice is close to or exceeds 200 million tons, 120 million tons of corn, and 85 million tons of sugarcane. During harvesting and processing, a large amount of fibrous by-pr...

Claims

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Application Information

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IPC IPC(8): C07C59/64C07C27/02C07C51/42
Inventor 欧仕益赵升强姚胜文黄才欢彭喜春
Owner GUANGXI WUZHOU PHARMA GRP
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