A kind of purification method of sucrose-6-acetate

Abstract

The invention provides a purification method for cane sugar-6-acetate. The purification method comprises the specific steps of: adding isoamylol in a cane sugar-6-acetate crude product on the condition of a reaction temperature of 20-80 DEG C; separating out crystals, and filtering; and drying the separated crystals in a vacuum drying box, wherein the volume ratio of isoamylol to the cane sugar-6-acetate crude product is 1: 1 to 5: 1. According to the purification method, isoamylol is used as an extraction agent, isoamylol is a polar solvent, and the polarity of cane sugar is greater than the polarity of cane sugar-6-acetate, so that cane sugar-6-acetate can be separated from isoamylol; moreover, the needed amount is low, the required temperature is low, and the requirement on equipment in industrial production is low; simultaneously, the purification method is high in economic benefits and meets the need of large-scale industrial production.

Description

technical field [0001] The invention relates to a method for purifying an intermediate of sucralose, in particular to a method for purifying sucrose-6-acetate. Background technique [0002] Sucralose, the English name is Sucralose, is the only functional sweetener that uses sucrose as a raw material. The sweetness can reach more than 600 times that of sucrose. It is a non-nutritive, efficient and harmless sweetener. [0003] Sucralose is a non-hygroscopic white crystalline powder with high chemical stability in acidic solution and good stability under light and heat conditions. It is easily soluble in ethanol and has a good linear relationship between the refractive index and solubility. [0004] At present, the "single group protection method" is usually used to finally synthesize sucralose. The advantage of this method is that sucralose can be synthesized in three steps by the single-group protection method, with few steps, simple operation, and low requirements on proces...

AI Technical Summary

Problems solved by technology

[0006] US7626016 purifies sucrose-6-acetate by ion exchange method. This method uses strong acidic ion-exchange resin with a particle size of 50mesh to 100mesh as an adsorbent, and uses 70% acetone aqueous solution as an eluent to separate and purify sucrose-6-acetate Esters, this method requires a large amount of solvent, and the treatment of ion exchange resins is troublesome, and the purity is not too high; US20070227897 uses anhydrous methanol for recrystallization under heating and reflux conditions, then cools to room temperature, and uses sucrose-6-B acid ester as seed crystal, overnight, to get more pure sucrose-6-acetate, this method is similar to US7932380, US4889928, US2011168568, the time required for this type of method is long and under the condition of heating and reflux, sucrose-6- The color of the crude acetate product will deepen; there are also some literatures that use column chromatography to separate and purify sucrose-6-acetate. This type of method uses a large amount of solvent and the product loss is relatively large