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Photocatalysed glucose microelectrode sensor and preparation method thereof

A microelectrode and glucose technology, applied in the field of electrochemical detection, can solve the problems of side effects of electroactive substances

Active Publication Date: 2015-07-22
MEDTRUM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The traditional glucose microelectrode sensor modifies the electrode by glucose oxidase. When the glucose microelectrode sensor detects blood sugar, it has a certain dependence on oxygen, and the detection must be carried out at a higher potential, so the coexisting electroactive substances may cause a series of side effects

Method used

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  • Photocatalysed glucose microelectrode sensor and preparation method thereof
  • Photocatalysed glucose microelectrode sensor and preparation method thereof
  • Photocatalysed glucose microelectrode sensor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Preparation of CdSeCdS semiconductor quantum dots

[0078] Weigh 0.0336g cadmium perchlorate hexahydrate (Cd(ClO 4 ) 2 ·6H 2 O) and 0.05 g sodium citrate dihydrate (Na 3 C 6 h 5 o 7 2H 2 O) were dissolved together in 45ml of deionized water, deoxygenated by nitrogen gas for 10min, and the pH value of the mixed solution was adjusted to 9.0 with 2 moles of sodium hydroxide (NaOH). Then add 0.003g selenourea (C 3 h 8 N 2 Se), and then pass nitrogen gas to remove oxygen for 1min, and finally put it into the microwave oven and heat it in the microwave for 1min, so that the color of the mixed solution changes from colorless to red, take out the mixed solution, and let it stand at room temperature to cool.

[0079] Finally, add 0.0015g thioacetamide (CH 3 CSNH 2 ), shake and mix evenly, inject the mixture into a cleaned three-necked bottle, and heat the reaction system in an oil bath for reflux reaction. The CdSeCdS quantum dots needed for the experiment can be ob...

Embodiment 2

[0082] Preparation of o-phenanthroline cobalt ([Co(Phen) 3 ] 2+ / 3+ )

[0083] According to the molar ratio of 1:3, weigh cobalt chloride hydrate (CoCl 2 2H 2 O) and o-phenanthroline (Phen, C 12 h 8 N 2 ·H 2 O) Put it into the grinding machine, mix and grind at room temperature, the color of the mixture first turns light pink, continue to grind, the color of the mixture gradually turns green, and grind until the color of the mixture gradually changes from green to orange.

[0084] CoCl 2 ·6H 2 The solid-state reaction of O and o-phenanthroline is a two-step reaction process through a green intermediate, which is expressed by the equation:

[0085]

[0086] To the synthesized o-phenanthroline cobalt compound (Co(Phen) 3 Cl 2 ), characterized by Fourier transform infrared spectroscopy. At 1800~400cm -1 Co(Phen) was determined in the range 3 Cl 2 Infrared spectrum, Figure 6 As shown, its main absorption peak position is: 1623cm -1 , 1516cm -1 , 1421cm -1 , 1...

Embodiment 3

[0088] Preparation of glucose microelectrode sensor (s1-s5):

[0089] Glucose microelectrode sensor (thickness 0.1mm, working electrode area 6mm 2 , counter electrode area 9mm 2 , the reference electrode area is 6mm 2 ), use photolithography, electroforming and injection molding technology to make MEMS (Micro-Electro-Mechanical System, Micro-Electro-Mechanic System) molds, use thermal molding technology to micro-cast micro-fiber arrays to form working electrodes, and spray directly on the electrode substrate The corresponding counter electrode pattern, reference electrode pattern, working electrode pattern and connecting wires are produced. The sprayed material can use nano-platinum gold, nano-silver or indium tin oxide.

[0090] The preparation process of the functional layer of the sensor is as follows: image 3 As shown, the layer-by-layer self-assembly method is adopted, including the following steps:

[0091] a) The indium tin oxide conductive glass electrode used as ...

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Abstract

The invention relates to the field of electrochemical detection and particularly relates to a photocatalysed glucose microelectrode sensor and a preparation method thereof. The photocatalysed glucose microelectrode sensor comprises a base material, wherein a working electrode, a counter electrode and a reference electrode are arranged on the base material, a semiconductor quantum dot modified layer and a glucose oxidase modified layer are arranged on a working region of the working electrode, a micro optical fiber is arranged in the base material, light transmitted by the micro optical fiber vertically penetrates through the working electrode, and a semiconductor quantum dot is a CdSe@CdS semiconductor quantum dot. The photocatalysed glucose microelectrode sensor provided by the invention can be used for detecting the blood glucose under a lower potential in the absence of oxygen.

Description

technical field [0001] The invention relates to the field of electrochemical detection, in particular to a photocatalytic glucose microelectrode sensor and a preparation method thereof. Background technique [0002] The traditional glucose microelectrode sensor uses glucose oxidase to modify the electrode. When the glucose microelectrode sensor detects blood sugar, it has a certain dependence on oxygen, and the detection must be carried out at a high potential, so the coexisting electroactive substances may cause a series of side effects. [0003] In recent years, the field of nanoscience has become the frontier of science in the new century, which will change human production and life style. At the same time, nanotechnology poses many new challenges to people in basic science and promotes the development of basic science. Semiconductor quantum dots are a typical structure of semiconductor nanomaterials, which have played an important role in the field of information techn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/26
Inventor 不公告发明人
Owner MEDTRUM TECH