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Dental implant and preparation method thereof

A dental implant, titanium-based technology, applied in dentistry, dental implants, dental restorations, etc., can solve the problems of low strength of the film layer, poor bonding strength between the film and the matrix, fatigue damage due to stress, etc., to achieve low cost, Excellent osteogenic differentiation induction ability and the effect of enhancing the strength of the membrane layer

Active Publication Date: 2014-01-29
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of low film strength of the nano-modified coating or film on the surface of dental implants in the prior art, poor bonding strength between the film and the substrate, fatigue damage due to stress, etc., the purpose of the present invention is to provide a surface that is in situ A dental implant with a grown honeycomb nano-titanium oxide film layer and its preparation method, thereby enhancing the strength of the film layer and the bonding strength between the film and the matrix, and enhancing the adhesion and alkaline phosphatase activity of bone marrow mesenchymal stem cells on the implant surface The expression of genes related to osteogenesis can enhance the induction ability of osteogenesis, thereby improving the long-term stability and success rate of dental implants

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  • Dental implant and preparation method thereof
  • Dental implant and preparation method thereof
  • Dental implant and preparation method thereof

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preparation example Construction

[0032] (1) Preparation of dental implant matrix

[0033] The common processing methods that can be used to process dental implant substrates from titanium substrates (such as medical pure titanium or titanium alloys) will not be described in detail here. It should be understood that as long as the dental implant substrates can be obtained, the processing methods include in the present invention. Dental implants are then surface polished, cleaned and pretreated. Likewise, the polishing and cleaning treatment of the titanium substrate is not particularly limited, and known methods can be used, and this pretreatment is not essential to the present invention. The surface topography of pretreated dental implants can be found in figure 1 , it can be seen from the figure that there is no obvious microstructure on the surface of the dental implant.

[0034] (2) Preparation of anodic oxidation electrolyte

[0035] The electrolyte used may be ethylene glycol solution of ammonium flu...

Embodiment 1

[0050] (1) Select pure titanium to process into dental implants;

[0051] (2) After polishing the surface of the implant, ultrasonically clean it with acetone, alcohol and deionized water for 30 minutes to obtain a clean and uniform surface;

[0052] (3) Preparation of anodic oxidation electrolyte: ethylene glycol as solvent, prepare ethylene glycol solution of 0.25% ammonium fluoride and 1% pure water;

[0053] (4) Preparation of regular titanium oxide nanotube films by anodic oxidation method: Constant voltage direct current anodic oxidation technology is adopted, dental implants are used as anodes, graphite electrodes or platinum electrodes are used as cathodes, and they are placed in the electrolyte prepared in the previous step; working voltage is 50V, the oxidation time is 2 hours, and the reaction temperature is room temperature;

[0054] (5) Prepare the electrolyte for electrochemical stripping: deionized water is used as the solvent, and a dilute sulfuric acid soluti...

Embodiment 2

[0066] (1) Select medical titanium to process into dental implants;

[0067] (2) After polishing the surface of the implant, ultrasonically clean it with acetone, alcohol and deionized water for 30 minutes to obtain a clean and uniform surface;

[0068] (3) Preparation of anodic oxidation electrolyte: ethylene glycol as solvent, prepare ethylene glycol solution of 0.25% ammonium fluoride and 1% pure water;

[0069] (4) Preparation of regular titanium oxide nanotube films by anodic oxidation method: Constant voltage direct current anodic oxidation technology is adopted, dental implants are used as anodes, graphite electrodes or platinum electrodes are used as cathodes, and they are placed in the electrolyte prepared in the previous step; working voltage is 60V, the oxidation time is 1 hour, and the reaction temperature is room temperature;

[0070] (5) Prepare the electrolyte for electrochemical stripping: deionized water is used as the solvent, and a dilute sulfuric acid solu...

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Abstract

The invention relates to a dental implant and a preparation method thereof. The dental implant comprises a titanium substrate and a honeycomb nano titanium oxide film layer, wherein the honeycomb nano titanium oxide film layer is formed on the surface of the titanium substrate in situ to form a honeycomb nano shape on the surface of the dental implant; the oxygen content of the honeycomb nano titanium oxide film layer is reduced with increase in thickness of the film layer and is gradually transited to the titanium substrate. The honeycomb nano titanium oxide film layer is formed on the surface of the titanium substrate in situ so as to form the honeycomb nano shape on the surface of the dental implant, wherein the honeycomb nano titanium oxide film layer is thin, has better strength, is not obviously layered with the titanium substrate and is firm in combination, and the regular nanostructure can effectively reinforce the adhesion of mesenchymal stem cells to the surface of the implant and the expression of alkaline phosphatase activities and osteogenesis-related genes, and shows superior osteogenic differentiation induction capacity, so that the long-term stability and the success rate of the dental implant are improved.

Description

technical field [0001] The invention relates to the field of dental implant materials, in particular to a dental implant with honeycomb nano-pattern on the surface and a preparation method thereof. Background technique [0002] With the improvement of social living standards and the aging of the population, the number of dental restorations and plastic surgery shows a continuous growth trend. Since dental implant technology is one of the important methods to restore dentition defect or loss, the development of dental implants has received great attention. Modification of the implant surface has been proved to be an effective method to promote osseointegration and improve the success rate of implants. At the same time, studies have shown that nanostructures on the implant surface, such as nanotube-like surface topography, can promote the attachment and functional expression of osteoblasts. , can also significantly promote the adhesion, proliferation and protein and gene expr...

Claims

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Application Information

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IPC IPC(8): A61C8/00C25D11/26
Inventor 刘宣勇钱仕
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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