A kind of pharmaceutical composition for treating diabetes and its preparation method
A composition and diabetes technology, applied in the field of medicine, can solve problems such as incomplete understanding, lack of treatment methods for etiology, complex etiology and pathogenesis, and achieve high total effective rate, no toxic and side effects, and high bioavailability Effect
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Embodiment 1
[0024] A pharmaceutical composition for treating diabetes, which is prepared from the following raw materials: 28 parts of Atractylodes macrocephala, 28 parts of Polyporus, 25 parts of white lentils, 25 parts of purslane, 24 parts of Fructus aurantii, 22 parts of bark of Albizia juniper, Radix Ophiopogon japonicus 20 parts, 20 parts of yam, 18 parts of radish, 18 parts of angelica, 15 parts of mulberry leaves, 15 parts of Alisma, 15 parts of japonica rice, 12 parts of licorice, 12 parts of trichosanthin, 12 parts of cassia twig, 10 parts of dried ginger, 10 parts of astragalus 10 parts of dogwood, 9 parts of ebony plum, 9 parts of Polygonatum odoratum, 9 parts of peach kernel, 7 parts of kudzu root, 7 parts of rehmannia glutinosa, 5 parts of schisandra, 5 parts of gardenia, 5 parts of Anemarrhena, and 3 parts of melon seeds.
[0025] Its preparation and taking method of the pharmaceutical composition of the present invention are: take the crude drug (proportioning unit: gram) o...
Embodiment 2
[0031] zoology experiment
[0032] Experimental animals: 50 SD rats, half male and half male, weighing 160-180 g, provided by the Animal Center of the First Affiliated Hospital of Shandong University. After the rats were adapted to feeding in the animal room for 5 days, 10 rats were randomly selected as the normal control group and fed with ordinary maintenance feed. High-sugar and high-fat feed formula: rat basic feed 68%, sucrose 10%, egg yolk powder 9%, lard 8%, cholesterol 1%, bile salt 0.2%.
[0033] Implementation method: the remaining 40 were fed with high-sugar and high-fat feed for 4 weeks. After 4 weeks, the rats were fasted for 24 hours, and streptozotocin (STZ) was injected intravenously at 20 mg / Kg, once every two days. Choose 36 successful rats of modeling, be divided into 3 groups at random, every group of 12, i.e. model group (do not use any medicine), the embodiment of the present invention 1 medicine group 10mg / Kg, control medicine group: use metformin hydr...
Embodiment 3
[0040] clinical information:
[0041] Materials and Methods: General information There were 71 outpatients with type 2 diabetes mellitus, including 37 males and 34 females, aged 49-75 years, with significantly elevated fasting blood glucose (FPG) and 2h postprandial blood glucose (2hPG). After taking the medicine prepared in Example 1 of the present invention for two courses of treatment, the above biochemical indicators were detected.
[0042] Cure: FPG<6.1mmol / L, 2h blood glucose (2hPG)<8.0mmol / L;
[0043] Effective: Fasting blood glucose (FPG) and postprandial 2h blood glucose (2hPG) have improved, but have not reached normal levels;
[0044] Ineffective: Fasting blood glucose (FPG) and postprandial 2h blood glucose (2hPG) did not change significantly;
[0045] Treatment effect: 49 cases were cured, 19 cases were effective, and 3 cases were ineffective. The total effective rate was over 95.8%.
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