Preparation method for chitosan-based electrostatic spinning combined wound dressing

A technology of electrospinning and wound dressing, which is applied in the field of preparation of chitosan-based electrospinning composite wound dressings, can solve the problems of increasing the difficulty of adding pure chitosan nanofiber membranes, high viscosity of the solution, and low solubility. Achieve the effect of relieving stress, good biocompatibility, and eliminating nervous tension

Inactive Publication Date: 2014-12-24
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low solubility of chitosan, it can only be dissolved in dilute acid aqueous solution, and the solution has high viscosity and the characteristics of polycation electrolyte. The Difficulty of Nanofiber Membranes

Method used

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  • Preparation method for chitosan-based electrostatic spinning combined wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method of chitosan-based electrospinning composite wound dressing, comprising the steps of:

[0030] (1) Mix 0.5ml tea tree essential oil and 0.1g lecithin in 0.5ml water and stir evenly, and ultrasonically disperse and degas to obtain an essential oil emulsion;

[0031] (2) 0.75g chitosan (viscosity average molecular weight 5.0×10 5 , the degree of deacetylation is 80-85%) was dissolved in 50ml of 90% acetic acid solution, 1ml of glycerin was added as a plasticizer, 1ml of essential oil emulsion was added, and stirred at room temperature until completely dissolved to obtain a spinning solution;

[0032] (3) Dissolve 1g of chitosan in 50ml of 2% acetic acid solution, add 1ml of glycerin as a plasticizer, stir at room temperature until completely dissolved to obtain a film-forming liquid, and use the cast film-forming method to prepare a chitosan film, uncover next standby;

[0033] (4) Coat the chitosan film on the electrospinning receiving plate, extrac...

Embodiment 2

[0036] A preparation method of chitosan-based electrospinning composite wound dressing, comprising the steps of:

[0037] (1) Mix 1ml of tea tree essential oil and 0.2g of lecithin in 1ml of water and stir evenly, and ultrasonically disperse and degas to obtain an essential oil emulsion;

[0038] (2) 1.5g chitosan (viscosity average molecular weight 5.0×10 5 , the degree of deacetylation is 80-85%) was dissolved in 50ml of 90% acetic acid solution, 2ml of glycerin was added as a plasticizer, 2ml of essential oil emulsion was added, and stirred at room temperature until completely dissolved to obtain a spinning solution;

[0039] (3) Dissolve 1.25g of chitosan in 50ml of 2% acetic acid solution, add 2ml of glycerin as a plasticizer, stir at room temperature until completely dissolved to obtain a film-forming liquid, and use the cast film-forming method to prepare a chitosan film. Take off the spare;

[0040] (4) Coat the chitosan film on the electrospinning receiving plate, e...

Embodiment 3

[0043] A preparation method of chitosan-based electrospinning composite wound dressing, comprising the steps of:

[0044] (1) Mix 0.75ml tea tree essential oil and 0.15g lecithin in 0.75ml water and stir evenly, and ultrasonically disperse and degas to prepare essential oil emulsion;

[0045] (2) 1g chitosan (viscosity average molecular weight 5.0×10 5 , the degree of deacetylation is 80-85%) was dissolved in 50ml of 90% acetic acid solution, 1.5ml of glycerin was added as a plasticizer, 1.5ml of essential oil emulsion was added, and stirred at room temperature until completely dissolved to obtain a spinning solution;

[0046] (3) Dissolve 0.75g of chitosan in 50ml of 2% acetic acid solution, add 0.75ml of glycerin as a plasticizer, stir at room temperature until completely dissolved to obtain a film-forming solution, and use the cast film-forming method to prepare a chitosan film , take off the spare;

[0047] (4) Cover the chitosan film on the electrospinning receiving pla...

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Abstract

The invention discloses a preparation method for a chitosan-based electrostatic spinning combined wound dressing. The preparation method comprises the steps: (1) entirely dissolving a certain amount of chitosan into a 90% acetic acid solution, adding a certain amount of glycerol, then adding a lecithin and tea essential oil mixture solution prepared according to a certain proportion, and performing ultrasonic dispersion to obtain a spinning solution; (2) entirely dissolving a certain amount of chitosan into a 2% acetic acid solution, adding a certain amount of glycerol, and performing casting membrane forming to obtain a chitosan membrane; (3) applying a layer of chitosan membrane on an electrostatic spinning receiving slab, performing electrostatic spinning by adopting the spinning solution to obtain an essential oil chitosan fiber particle layer; (4) after electrostatic spinning is finished, covering a layer of chitosan membrane, performing compression moulding at a certain temperature to obtain the chitosan-based electrostatic spinning combined wound dressing. The dressing has durable and wide-spectrum antisepsis effects, as well as excellent controlled-release antisepsis and comfortable properties, is good in biocompatibility, has certain plant aroma, and can be widely applied in the fields of textile industry, health and medicine, and biomedicine and the like as a medical material, a textile garment material, an antisepsis material and the like.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a preparation method of a chitosan-based electrostatic spinning composite wound dressing. Background technique [0002] Chitosan is a natural macromolecule biological polysaccharide chitin deacetylation product, has excellent solvent resistance and alkali resistance, good biocompatibility and skin affinity, antibacterial, film-forming, breathable, It has good water absorption and moisturizing properties, can stop bleeding, promote wound healing, etc., and can be used as a medical material. However, due to the high brittleness and poor mechanical properties of chitosan, its use alone is limited. At present, there are a large number of literature reports that chitosan and other polymers are blended and modified to prepare dressing films with excellent properties. The introduction of other polymers will affect some properties compared to the pure chitosan film. Electr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44D01F9/00D01F1/10D01D5/00
Inventor 葛彦汤佳鹏
Owner NANTONG UNIVERSITY
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