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an antibacterial film

A bacteriostatic agent and copolymer technology, applied in the field of bacteriostatic film, can solve the problems of rising risk of life-threatening and inability to effectively prevent large-scale infection, so as to inhibit the regeneration of bacterial flora, prevent large-scale infection, and prevent serious infection Effect

Active Publication Date: 2016-02-10
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional trauma treatment is to wash the wound with antibacterial agent, fix it with loose absorbent cotton, and wait for transfer treatment; if the peritoneum is injured, it is treated with temporary suture with patch; these treatment methods cannot effectively prevent the occurrence of large-scale infection, and the wounded The chance of facing life-threatening complications due to complications during the transfer process is greatly increased

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Prepare the antibacterial film as follows:

[0044] (1) Prepare a mixed solution of high molecular polymer and bacteriostatic agent: dissolve polyvinylidene fluoride (PVDF) and glycolide copolymer (GA / LA=25 / 75) in a mixed solvent of DMF and acetone (DMF The volume ratio of acetone / acetone is 2 / 1), and it is prepared into a mixed solution with a concentration of 20% (W / V), and 1% silver sulfadiazine solution is added to it. Calculated according to the bacteriostatic active ingredients, the weight content of the bacteriostatic agent is 1% based on the total weight of the polymer; after ultrasonication for 10-20 minutes, it is uniformly dispersed, and stirred at room temperature for 2-5 hours.

[0045] (2) Preparation of composite antibacterial fiber membrane: inject the mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 25KV, a solution flow rate of 2ml / h, and a receiving distance of 18cm; electrospinni...

Embodiment 2

[0050] Prepare the antibacterial film as follows:

[0051] (1) Prepare a mixed solution of high molecular polymer and bacteriostatic agent: dissolve polyvinylidene fluoride (PVDF) and glycolide copolymer (GA / LA=50 / 50) in a mixed solvent of DMF and acetone (DMF The volume ratio of acetone / acetone is 2 / 1), and it is prepared into a mixed solution with a concentration of 5% (W / V), and 0.1% zinc sulfadiazine solution is added into it. Calculated according to the bacteriostatic active ingredient, the weight content of the bacteriostatic agent is 0.1% based on the total weight of the polymer; after 10-20 minutes of ultrasound, it is uniformly dispersed, and stirred at room temperature for 2-5 hours.

[0052] (2) Preparation of composite antibacterial fiber membrane: inject the mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a high voltage power supply with a voltage of 30KV, a solution flow rate of 5ml / h, and a receiving distance of 25cm; electrospinning ...

Embodiment 3

[0057] Prepare the antibacterial film as follows:

[0058] (1) Prepare a mixed solution of high molecular polymer and bacteriostatic agent: dissolve polyvinylidene fluoride (PVDF) and glycolide caprolactone copolymer (GA / CL=80 / 20) in a mixed solvent of DMF and acetone (The volume ratio of DMF / acetone is 2 / 1), prepare a mixed solution with a concentration of 10% (W / V), add 2% of nano-silver into it, and calculate according to the bacteriostatic active ingredient, the weight content of the bacteriostatic agent is 2% based on the total weight of the polymer; after ultrasonication for 10-20 minutes, it is uniformly dispersed, and stirred at room temperature for 2-5 hours.

[0059] (2) Preparation of composite antibacterial fiber membrane: inject the mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 10KV, a solution flow rate of 1ml / h, and a receiving distance of 5cm; electrospinning After 100 min, the thicknes...

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Abstract

The invention discloses a bacteriostatic film which comprises the following raw material components: polyvinylidene fluoride, glycolide lactide copolymer and / or glycolide caprolactone copolymer, and a bacteriostatic agent. The bacteriostatic film can be obtained through high-voltage electrostatic spinning, can effectively prevent bacteria from colonization on the surfaces of an implanted material and kill bacteria at the periphery of the implanted material so as to effectively prevent large-area infection, and has a wide application prospect for emergency treatment of trauma such as a firearm injury.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a bacteriostatic film capable of effectively preventing bacteria from penetrating, preventing bacteria from colonizing on the surface of a material and simultaneously killing bacteria around the material. Background technique [0002] A large amount of devitalized or necrotic tissue, blood clots, foreign bodies, and contaminated bacteria often accumulate in the wound tract, which is characteristic of war wounds. These substances are places that cannot be reached by blood circulation, and are also suitable places for bacteria to survive, grow and multiply, so they are not conducive to wound healing, and also reduce the anti-infection ability of wounds. Such wounds are all infected and mostly mixed. Infect. According to foreign statistics, the bacterial species of such infections mainly include: fecal bacillus (such as aerobic anaerobic bacteria and tetanus bacilli, etc....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/18A61L27/16A61L27/54A61L27/50A61L15/26A61L15/24A61L15/44A61L15/42D01D5/00
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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