Superparamagnetic nanospheres and preparation method thereof

A superparamagnetic and nanosphere technology, applied in the field of nanomaterials, can solve the problems of low particle loading density, uneven particle distribution, and uneven particle size, and achieve the effects of improving stability, overcoming uneven distribution, and increasing loading density

Active Publication Date: 2014-04-16
SHENZHEN INST OF ADVANCED TECH
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Problems solved by technology

[0006] The purpose of the present invention is to provide a superparamagnetic nanosphere with excellent superparamagnetic properties, uniform particle size, rapid magnetic separation, and stable dispersion in water and its preparation method, aiming at solving the problem of existing SiO 2 / Fe 3 o 4 The active ingredient of nanocomposite Fe 3 o 4 Particle distribution is uneven, and Fe 3 o 4 The disadvantage of low particle loading density avoids the disadvantages of non-uniform particle size and low crystallinity of the aqueous phase synthesis method in the existing preparation method, and simplifies the complex process of particle surface modification, assembly and phase transfer

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  • Superparamagnetic nanospheres and preparation method thereof
  • Superparamagnetic nanospheres and preparation method thereof

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[0024] Correspondingly, the embodiment of the present invention also provides a preparation method of the above-mentioned superparamagnetic nanospheres, the process flow of the preparation method is as follows figure 1 shown. The preparation method of the superparamagnetic nanosphere comprises the following steps:

[0025] S01. Obtain the above SiO 2 nanoparticles;

[0026] S02. On SiO 2 In situ growth of Fe on the outer surface of nanoparticles 3 o 4 Nanoparticles: the SiO in step S01 2 The nanoparticles are miscible with the polyol solution, then the organic iron compound is added, and heated to reflux to obtain the above SiO 2 In situ growth of nanoparticles as templates to form Fe 3 o 4 Shell SiO 2 Fe 3 o 4 nanospheres;

[0027] S03. In Fe 3 o 4 The outer surface of the layer is coated with SiO 2 Shell: SiO2 in step S02 2 Fe 3 o 4 The composite nanospheres are dispersed in a surfactant-solution, and tetraethyl orthosilicate is added under alkaline conditi...

Embodiment 1

[0042] A superparamagnetic nanosphere and a preparation method thereof. The preparation method of this superparamagnetic nanosphere is as follows

[0043] S11. Obtain SiO 2 Nanoparticles: Mix 75mL of cyclohexane, 18mL of n-hexanol and 17.7mL of Triton X-100, add 4.2mL of water and 600 μL of ammonia to form an inverse microemulsion; then add 1.5mL of TEOS, and the inverse microemulsion was stirred at room temperature for 48 h; then 70 mL of ethanol was added to break the emulsion, centrifuged at 6000 rpm for 5 min, and the precipitate was washed with isopropanol, ethanol and water in sequence to obtain SiO with a diameter of 82 nm. 2 ball;

[0044] S12. In situ growth of Fe 3 o 4 Nanoparticles: 75 mg of SiO obtained in step S11 2 Dissolve the ball in 500 μL of ethanol, add it into a two-necked round-bottomed flask containing 5ml triethylene glycol and 66mg iron acetylacetonate; drain the ethanol in the solution under vacuum, raise the temperature to 110°C and keep it for 2...

Embodiment 2

[0047] A superparamagnetic nanosphere and a preparation method thereof. The preparation method of this superparamagnetic nanosphere is as follows

[0048] S21. Obtain SiO 2 Nanoparticles: Mix 75mL of cyclohexane, 18mL of n-hexanol and 17.7mL of Triton X-100, add 4.2mL of water and 600 μL of ammonia to form an inverse microemulsion; then add 1.5mL of TEOS, and the inverse microemulsion was stirred at room temperature for 48 h; then 70 mL of ethanol was added to break the emulsion, centrifuged at 6000 rpm for 5 min, and the precipitate was washed with isopropanol, ethanol and water in sequence to obtain SiO with a diameter of 82 nm. 2 ball;

[0049] S22. In situ growth of Fe 3 o 4 Nanoparticles: 375 mg of SiO obtained in step S21 2 Dissolve the ball in 2.5ml of ethanol, add it into a two-necked round-bottomed flask containing 25ml of triethylene glycol and 330mg of iron acetylacetonate; drain the ethanol in the solution under vacuum, raise the temperature to 110°C and keep ...

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Abstract

The invention provides superparamagnetic nanospheres and a preparation method of the superparamagnetic nanospheres. Each superparamagnetic nanosphere comprises SiO2 nano-particles, a Fe3O4 layer and a SiO2 layer, wherein the Fe3O4 nano-particles grow in situ to form a shell with the SiO2 nano-particles as the template of the Fe3O4 layer, and the SiO2 layer is deposited on the outer surface of the Fe3O4 layer to form a coating layer. The colloid SiO2 nano-particles are used as the template of each superparamagnetic nanosphere, and thus the size of the SiO2@Fe3O4@SiO2 nanosphere can be adjusted by adjusting the size of the template SiO2 nano-particles. Because the surface of the template SiO2 nano-particles is coated with the Fe3O4 nano-particles in an in-situ growth mode, the load intensity of the superparamagnetic nanospheres is greatly increased, and the synthesis conditions can be simplified. Meanwhile, the outer surfaces of the Fe3O4 layers are coated with the SiO2, the stability of the Fe3O4@SiO2 nanospheres can be obviously improved.

Description

technical field [0001] The invention belongs to the field of nanomaterials, in particular to a superparamagnetic nanosphere and a preparation method thereof. Background technique [0002] Magnetic separation technology is a new type of separation technology for the comprehensive separation of biomolecules and cells based on solid phase carriers. The principle is to use the specific interaction between the ligand (or receptor) on the surface of the functionalized magnetic particles and the receptor (or ligand), such as: antibody-antigen interaction or avidin-biotin and other systems to achieve Rapid separation of targeted biological target molecules. Based on the principle of hydrodynamics, the magnetic particles can quickly contact the target biomolecules to be separated so that the target molecules to be separated are bound to the surface of the magnetic particles. Then, under the action of an external magnetic field, the target biomolecules or cells are rapidly enriched ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/11B01J13/02A61K49/08A61K47/04C12N5/00C07K1/14
Inventor 粟武黄亮敖丽娇
Owner SHENZHEN INST OF ADVANCED TECH
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