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Method for preparing antibacterial diamond-like carbon/hydroxyapatite gradient multi-element nano coating

A technology of hydroxyapatite and composite hydroxyapatite, which is applied in the field of preparation of medical composite coating materials, and can solve the problems of reduced efficacy of antibiotics and infection

Inactive Publication Date: 2014-06-25
CHINA UNIV OF MINING & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various antibiotics are normally used to solve the problem of bacterial infection during surgery, but the biofilm formed on the surface of the implant increases the resistance of bacteria to antibiotics, resulting in a decrease in the efficacy of antibiotics

Method used

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  • Method for preparing antibacterial diamond-like carbon/hydroxyapatite gradient multi-element nano coating

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: The substrate material is a titanium-based alloy, cobalt-based alloy or stainless steel for artificial joint replacement. After ultrasonic cleaning and pretreatment, it is placed in a magnetron sputtering vapor deposition system, and the following steps are carried out: (a) argon gas into the vacuum chamber, keep the air pressure at 1-1.5Pa, turn on the bias power supply and adjust it to –1000V, and perform argon ion discharge cleaning and activation on the surface of the substrate for 20 minutes; (b) use a high-purity Ti target as the sputtering target, Ar ion bombardment, the control current is 2.0A, the bias voltage is –1000V, the duty cycle is 50%, and the sputtering deposition time is 20 minutes; (c) single-layer diamond-like carbon deposition, the Ti target sputtering process continues, and at the same time into high-purity CH 4 , control flow rate 8sccm as initial, increase 2sccm every 2 minutes, until added to 40sccm, discharge pressure is 1.0Pa, c...

Embodiment 2

[0021] Embodiment 2: The base material is a titanium-based alloy, cobalt-based alloy or stainless steel for artificial joint replacement. After ultrasonic cleaning and pretreatment, it is placed in a magnetron sputtering vapor deposition system, and the following steps are carried out: (a) argon gas into the vacuum chamber, keep the air pressure at 1-1.5Pa, turn on the bias power supply and adjust it to –1000V, and perform argon ion discharge cleaning and activation on the surface of the substrate for 20 minutes; (b) use a high-purity Ti target as the sputtering target, Ar ion bombardment, the control current is 2.0A, the bias voltage is –1000V, the duty cycle is 50%, and the sputtering deposition time is 20 minutes; (c) single-layer diamond-like carbon deposition, the Ti target sputtering process continues, and at the same time into high-purity CH 4 , control flow rate 8sccm as initial, increase 2sccm every 2 minutes until it reaches 40sccm, discharge pressure is 1.0Pa, contr...

Embodiment 3

[0022] Embodiment 3: The substrate material is a titanium-based alloy, cobalt-based alloy or stainless steel for artificial joint replacement. After ultrasonic cleaning and pretreatment, it is placed in a magnetron sputtering vapor deposition system, and the following steps are carried out: (a) argon gas into the vacuum chamber, keep the air pressure at 1-1.5Pa, turn on the bias power supply and adjust it to –1000V, and perform argon ion discharge cleaning and activation on the surface of the substrate for 20 minutes; (b) use a high-purity Ti target as the sputtering target, Ar ion bombardment, the control current is 2.0A, the bias voltage is –1000V, the duty cycle is 50%, and the sputtering deposition time is 20 minutes; (c) single-layer diamond-like carbon deposition, the Ti target sputtering process continues, and at the same time into high-purity CH 4 , control flow rate 8sccm as initial, increase 2sccm every 2 minutes until it reaches 40sccm, discharge pressure is 1.0Pa, ...

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Abstract

The invention provides a method for preparing antibacterial diamond-like carbon / hydroxyapatite gradient multi-element nano coating, and belongs to a method for preparing a medical composite coating material. Diamond-like carbon layers and hydroxyapatite layers are alternatively deposited on a metal or an alloy substrate by using an unbalanced magnetron sputtering technology, to finally obtain the diamond-like carbon / hydroxyapatite gradient multi-element nano coating. The diamond-like carbon / hydroxyapatite gradient multi-element nano coating prepared based on a design theory of an inert material + an active material in the invention has such characteristics in a body fluid environment as high hardness, wear resistance, integrated antibacterial and biological activity and the like. The characteristics lie in that the high-hardness and high-density diamond-like carbon coating provides good carrying capacity, abrasion resistance and shielding particle release capacity, and the deposited silver and titanium dioxide doped hydroxyapatite coating can promote the quick formation of new bones on the interface of a human bone tissue and hydroxyapatite and can achieve the purposes of disinfection and anti-infection.

Description

technical field [0001] The invention relates to a preparation method for a medical composite coating material, in particular to a preparation method for depositing a diamond-like carbon / hydroxyapatite nanometer composite coating on the surface of a medical implant. Background technique [0002] Biomaterials, especially those used for medical implants, must meet various requirements for clinical use due to their direct contact with human tissue. In addition to having good physical, chemical and mechanical properties of general materials, they must also meet their specific requirements. Biological performance. Traditional medical metals, ceramics, and polymers are biologically inert materials. Long-term clinical application has found that the combination of the prosthesis and bone tissue is only a mechanical lock because it does not have biological activity, and it is not easy to firmly bond with the tissue. After being implanted in the body, it is affected by the physiologic...

Claims

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Application Information

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IPC IPC(8): C23C14/06C23C14/35A61L27/32A61L27/30A61L27/54
Inventor 亓健伟刘洪涛罗勇张德坤王庆良
Owner CHINA UNIV OF MINING & TECH
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