Preparation method of injectable porous compound bone cement

A bone cement and injection technology, applied in the field of biomedical materials, can solve problems affecting the mechanical properties and biocompatibility of bone cement, and achieve the effect of reducing the elastic modulus

Active Publication Date: 2014-07-02
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to provide a preparation method of injectable porous composite bone cement, which solves the problem that the residual

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  • Preparation method of injectable porous compound bone cement

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Example Embodiment

[0053] The preparation method of an injectable porous composite bone cement of the present invention specifically includes the following steps:

[0054] Step 1: Preparation of bioceramic hollow microspheres

[0055] Step 1.1: Take 5%-20% of the ceramic powder and 80%-95% of distilled water according to the volume percentage, and add the obtained ceramic powder to the distilled water and mix well to obtain the ceramic suspension. Turbid liquid; among them, ceramic powder is one or two of calcium phosphate bioceramics and bioglass; calcium phosphate bioceramics are hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), phosphoric acid One of calcium;

[0056] Step 1.2: Take 97%~99.5% of the ceramic suspension and 0.5%~3% of the binder according to the mass percentage, and add the obtained binder to the ceramic suspension. Mix uniformly to obtain ceramic impregnated slurry; wherein the binder is polyvinyl alcohol or carboxymethyl cellulose;

[0057] Step 1.3: Take polymer microspheres wi...

Example Embodiment

[0088] Example 1

[0089] Step 1: Preparation of β-TCP hollow microspheres

[0090] Take 10ml of β-TCP powder and 90ml of distilled water; add β-TCP to distilled water and mix well to obtain β-TCP suspension; take 98g of β-TCP suspension and 2g of polyvinyl alcohol; add polyvinyl alcohol to β- TCP suspension, mix evenly to obtain β-TCP impregnating slurry; take epoxy resin microspheres with a diameter of 600μm and immerse them in β-TCP impregnating slurry for 6 times, each time after dipping in 60℃ environment Drying, and finally sintering at a temperature of 1300°C in the atmosphere for 1 hour to obtain β-TCP hollow microspheres;

[0091] Step 2: Preparation of injectable bone cement precursor

[0092] Take 0.051g of methyl methacrylate monomer, 0.0013g of N,N-dimethyl-p-toluidine, 0.0039g of hydroquinone, 78.9038g of methyl methacrylate-styrene copolymer, and polymethyl methacrylate 15.78g, barium sulfate 5.26g, mix the above components uniformly to obtain an injectable polymethyl...

Example Embodiment

[0097] Example 2

[0098] Step 1: Preparation of hydroxyapatite hollow microspheres

[0099] Take 5ml of hydroxyapatite powder and 95ml of distilled water; add hydroxyapatite into distilled water and mix well to obtain a hydroxyapatite suspension; take 97g of hydroxyapatite suspension and carboxymethyl cellulose according to mass percentage 3g; Add carboxymethyl cellulose to the hydroxyapatite suspension and mix well to obtain a hydroxyapatite impregnated slurry; take phenolic resin microspheres with a diameter of 300μm and immerse 10 in the hydroxyapatite impregnated slurry After each immersion, they were dried in an environment of 60°C, and finally sintered at a temperature of 1250°C in the atmosphere for 2 hours to obtain hydroxyapatite hollow microspheres;

[0100] Step 2: Preparation of injectable bone cement precursor

[0101] Take 0.05g of methyl methacrylate monomer, 0.001g of N,N-dimethyl-p-toluidine, 0.003g of hydroquinone, 82.946g of methyl methacrylate styrene copolymer, ...

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Abstract

The invention discloses a preparation method of injectable porous compound bone cement. The preparation method disclosed by the invention comprises the following steps of firstly, respectively preparing precursors of a biological ceramic hollow micro-balloon and injectable bone cement; then, adding the prepared biological ceramic hollow microballoon into the precursor of the bone cement, uniformly mixing to obtain a porous compound bone cement pre-prepared body, and finally, injecting, forming and selfcuring the porous compound bone cement to obtain the injectable porous compound bone cement. According to the preparation method of the injectable porous compound bone cement, the problem that the mechanical property and the biocompatibility of bone cement are influenced by a reaction product or a pore-forming agent remained in the current porous bone cement preparation method is solved; the elasticity modulus of the injectable porous compound bone cement is reduced obviously and effectively; no any product is remained; the injectable property of bone cement is not influenced; the preparation method of the injectable porous compound bone cement disclosed by the invention can be widely applied in the biomedical fields of orthopaedic implant fixation, face lifting, spine repairing and forming and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of an injectable porous composite bone cement. Background technique [0002] Bone cement is a biomaterial used to fill the gap between bone and implant or bone cavity and has self-setting properties. It was first used in the replacement of femoral prosthetic joints fixed by bone cement, which can ensure the immediate stability of the prosthesis after surgery. There is no micromotion at the bone tissue-bone cement-prosthesis interface, allowing early postoperative weight bearing. At present, bone cement has been widely used in orthopedic clinics, especially in facial cosmetic repair and spinal repair molding. Since this type of repair technique must be minimally invasive, good injectability of the bone cement is required. [0003] At present, the main injectable bone cements used in the clinical repair of vertebral bodies include pol...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56C08L51/00C08F265/06C08K13/04C08K7/18C08K3/30C04B12/02C04B28/34C04B38/04C04B14/02
Inventor 汤玉斐赵康陈磊苗芊
Owner XIAN UNIV OF TECH
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