Preparation method of nano material-based bionic bone scaffold

A nanomaterial, bionic bone technology, applied in medical science, prosthesis and other directions, can solve the problems of poor mechanical strength, non-degradation, poor toughness, etc., and achieve the effects of improving mechanical properties, easy adhesion, and fast degradation.

Inactive Publication Date: 2014-07-09
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, inorganic materials are similar to the inorganic structure and composition of bone tissue, have excellent osseointegration and osteoconduction properties, but have poor toughness, poor mechanical strength, and are not easy to degrade; organic materials have good biocompatibility, but their Poor mechanical strength, difficult to load

Method used

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  • Preparation method of nano material-based bionic bone scaffold

Examples

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Embodiment 1

[0026] A method for preparing a bionic bone scaffold based on nanomaterials, the preparation process steps are as follows:

[0027] 1) Negative type design and manufacture: The negative type is designed with the help of CATIA V5R19 (France, Dassault System). The shape of the stent determines the macroscopic shape of the stent. The shape of the stent selected in this embodiment is cylindrical, with a diameter of 4 mm and a height of 3 mm. Save the negative three-dimensional solid model in STL format, import it into the fusion deposition molding equipment (FDM300, Stratasys), use ABS as the material, manufacture the negative component, remove the residual wires on the surface of the negative, assemble, and obtain the combined negative of the bracket type mold.

[0028] 2) Preparation of slurry: Dissolve 0.4g of PLGA in 1ml of dichloromethane, then add 1.6g of nano-sized β-TCP, and finally add 4ml of deionized water, and place it in an oscillating mill (MM301, Retsch, Germany), ...

Embodiment 2

[0033] This example is basically the same as Example 1, except that in step 2), 0.6g of PLGA and 1.4g of nano-sized β-TCP are used to prepare a bionic bone scaffold.

Embodiment 3

[0035] This example is basically the same as Example 1, except that in step 2), 0.8g PLGA and 1.6g nano-sized β-TCP were used to prepare the bionic bone scaffold.

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Abstract

The invention discloses a preparation method of a nano material-based bionic bone scaffold. The preparation method comprises following steps: a negative die is prepared via fused deposition modeling; dissolved biomaterial PLGA is mixed with nano-grade beta-TCP powder, and an obtained mixture is mixed uniformly using a vibration grinder; an obtained slurry is injected into the negative die via negative pressure method, and the negative die is delivered into a freeze dryer for freeze drying; and the negative die is removed so as to obtain the nano material-based bionic cone scaffold. The nano material-based bionic cone scaffold is capable of satisfying requirements on scaffold materials, structures, and strength; controllable adjustment on appearance and porosity is realized; customized manufacturing of scaffolds implanted at bone defect parts is realized; success rate of complex bone defect treatment in clinic is increased effectively; and application prospect in clinic is promising.

Description

technical field [0001] The invention relates to a method for preparing a bionic bone scaffold based on nanomaterials, and belongs to the technical fields of additive manufacturing, biomanufacturing, nanomaterial modification, and the like. Background technique [0002] At present, autologous bone grafting is the best method for bone defect repair in clinical practice. However, the source of autogenous bone is limited, and it is not suitable for the repair of large-scale bone defects. On the other hand, allogeneic bone transplantation is also an effective method, but there are also problems such as rejection, contradiction between supply and demand, and virus and disease transmission. Therefore, applying tissue engineering technology and using bionic bone made of biomaterials is one of the most promising technologies to solve the problem of insufficient bone source. [0003] Additive manufacturing technology uses the method of gradually accumulating materials to manufacture...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/08A61L27/56
Inventor 林柳兰高海涛董洋洋胡庆夕
Owner SHANGHAI UNIV
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