Erythromycin estolate tablet and preparation method thereof

A technology based on erythromycin and erythromycin tablets, applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of affecting the uniformity and stability of tablet quality and affecting the quality of tablets , affecting the stability of drug efficacy and other issues, to achieve the effect of being suitable for industrial application, simple and easy to control the preparation method, and uniform and stable quality

Active Publication Date: 2015-01-14
TEYI PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Yito erythromycin tablets are generally ordinary compressed tablets. If the friability is not well controlled, it is easy to break, crack and shatter, which will affect the quality of the tablet.
The dissolution rate of Etoerythromycin Tablets depends on the firmness of Etoerythromycin Tablets granules. Failure to control the firmness of Etoerythromycin Tablets will also affect the uniformity and stability of tablet quality, thereby affecting the stability of drug efficacy.

Method used

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  • Erythromycin estolate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Etto erythromycin tablets are obtained through the preparation method of the following steps, and the schematic diagram of its preparation process is as follows: figure 1 Shown:

[0027] (1) Weighing raw materials by weight: 375 parts of erythromycin Eto, 79.5 parts of cornstarch, 30 parts of hypromellose, 5.4 parts of hypromellose, 1.44 parts of sodium lauryl sulfate, 249.6 parts of purified water , 7.38 parts of sodium starch glycolate, 5.88 parts of magnesium stearate;

[0028] (2) Preparation of granulation binder: In the pulping container, first dissolve 1.44 parts of sodium lauryl sulfate with a small amount of hot purified water, then add 24 parts of purified water and 13.5 parts of cornstarch to dilute into a suspension , weigh and add the remaining purified water heated to a temperature above 95°C, then add 5.4 parts of hypromellose and stir evenly quickly, punch the slurry, and stir evenly to obtain a mixed slurry, which is set aside;

[0029] (3) Wet granul...

Embodiment 2

[0034] Etto erythromycin tablets are obtained through the preparation method of the following steps, and the schematic diagram of its preparation process is as follows: figure 1 Shown:

[0035] (1) Weighing raw materials by weight: 375 parts of erythromycin Eto, 75 parts of cornstarch, 25 parts of hypromellose, 4 parts of hypromellose, 1 part of sodium lauryl sulfate, 240 parts of purified water , 6 parts of sodium starch glycolate, 4.5 parts of magnesium stearate;

[0036] (2) Preparation of granulation adhesive: first dissolve 1 part of sodium lauryl sulfate with a small amount of hot purified water, then add 23 parts of purified water and 12.7 parts of cornstarch, dilute into a suspension, weigh and heat to temperature Add the remaining purified water above 95°C, then add 4 parts of hypromellose and stir evenly, rinse the pulp, and stir evenly to obtain a mixed pulp, which is ready for use;

[0037] (3) Wet granulation: add 375 parts of Etoerythromycin and 25 parts of hyd...

Embodiment 3

[0042] Etto erythromycin tablets are obtained through the preparation method of the following steps, and the schematic diagram of its preparation process is as follows: figure 1 Shown:

[0043] (1) Weighing raw materials by weight: 375 parts of erythromycin Eto, 85 parts of cornstarch, 35 parts of hypromellose, 6 parts of hypromellose, 2 parts of sodium lauryl sulfate, 260 parts of purified water , 8 parts of sodium starch glycolate, 6 parts of magnesium stearate;

[0044] (2) Preparation of granulation adhesive: first dissolve 2 parts of sodium lauryl sulfate with a small amount of hot purified water, then add 25 parts of purified water and 14.4 parts of cornstarch, dilute into a suspension, weigh and heat to temperature Add the remaining purified water above 95°C, then add 6 parts of hypromellose and stir evenly, rinse the pulp, and stir evenly to obtain a mixed pulp, which is ready for use;

[0045](3) Wet granulation: Add 375 parts of Etoerythromycin and 35 parts of hydr...

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Abstract

The invention relates to an erythromycin estolate tablet and a preparation method thereof. The erythromycin estolate tablet consists of the following raw material components in parts by weight: 375 parts of erythromycin estolate, 75-85 parts of corn starch, 25-35 parts of hydroxypropylcellulose, 4-6 parts of hydroxypropyl methylcellulose, 1-2 parts of lauryl sodium sulfate, 240-260 parts of purified water, 6-8 parts of carboxymethyl starch sodium and 4.5-6 parts of magnesium stearate. By the synergistic effect of control on the stirring speed and the shearing speed, selection of the dosage of an adhesive, the control on the particle size of wet particles and dry particles, the control on tableting pressure and the like, the hardness and friability of the erythromycin estolate tablet reach the best state so that the product quality is improved, the dissolution rate of the product is guaranteed, the uniformity and stability of the quality are further guaranteed, the medicinal effect is stable and the process is simple and easy to control, so the erythromycin estolate tablet is suitable for industrial application.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to erythromycin erythromycin and its preparation method. Background technique [0002] Etoerythromycin is the dodecyl sulfate of erythromycin propionate, which has antibacterial activity against Staphylococcus, various groups of Streptococcus and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. may also be sensitive to this product. The product also has antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; it also has inhibitory effect on Legionella, Campylobacter fetalis, certain spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia . This strain is a bacteriostatic agent, but it also has a bactericidal effect on some bacteria at high concentrations. [0003] Etto erythromycin tablets are generally compressed tablets. If the friability is not well controlled, i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/7048A61K47/38A61K47/36A61P31/04
Inventor 赵瑞胜
Owner TEYI PHARMACEUTICAL GROUP CO LTD
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