Coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and preparation method thereof

A technology of vascular endothelium and coronary artery, applied in the field of coronary stent and preparation, can solve problems such as easily damaged coating

Inactive Publication Date: 2014-08-20
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used method is to use high temperature or disinfectant for disinfection and sterilization, but these methods are easy to damage the coating

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Take the stainless steel bracket and use acetone and deionized water to sonicate in turn, take it out, and dry the bracket with nitrogen flow;

[0030] 2. Take dopamine hydrochloride and lysine, add the dopamine solution prepared by buffer solution with pH=6, the concentration is 1-5 mg / mL. Soak the stent in the above solution and place it in a water bath at 20°C for 1 hour. After the reaction is completed, the stent is taken out, cleaned with distilled water, and then soaked in distilled water for cleaning. Take out the stent and blow it dry with nitrogen flow;

[0031] 3. Prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water at a concentration of 10mg / mL, soak the stent in it to fully react, take out the stent after the reaction is completed, rinse it repeatedly with distilled water, and blow it with nitrogen flow blow it dry;

[0032] 4. Dissolve MPC in distilled water to make a solution with a concentration of 10mg / mL, add BIS and TEMED to...

Embodiment 2

[0036] 1. Take the magnesium alloy stent and ultrasonically treat it with methanol and deionized water in turn, take it out, and dry the stent with nitrogen flow;

[0037] 2. Take dopamine hydrochloride and lysine, and add the dopamine solution prepared by buffer solution with pH=8, the concentration is 5-10 mg / mL. Soak the stent in the above solution and place it in a water bath at 60°C for 6 hours. After the reaction is completed, the stent is taken out, cleaned with distilled water, and then soaked in distilled water for cleaning. Take out the stent and blow it dry with nitrogen flow;

[0038] 3. Prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water at a concentration of 150mg / mL, soak the stent in it to fully react, take out the stent after the reaction is completed, rinse it repeatedly with distilled water, and blow it with nitrogen flow blow it dry;

[0039] 4. Dissolve MPC in distilled water to make a solution with a concentration of 150mg / mL, ad...

Embodiment 3

[0043] 1. Take the platinum alloy stent and ultrasonically treat it with propanol and deionized water in turn, take it out, and dry the stent with nitrogen flow;

[0044] 2. Take dopamine hydrochloride and lysine, add pH=9 buffer solution to prepare dopamine solution, the concentration is 90-100mg / mL. Soak the stent in the above solution and place it in a water bath at 100°C for 10 h. After the reaction is completed, the stent is taken out, cleaned with distilled water, and then soaked in distilled water for cleaning. Take out the stent and blow it dry with nitrogen flow;

[0045] 3. Prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water at a concentration of 400mg / mL, soak the stent in it to fully react, take out the stent after the reaction is completed, rinse it repeatedly with distilled water, and blow it with nitrogen flow blow it dry;

[0046] 4. Dissolve MPC in distilled water to make a solution, the concentration is 400mg / mL, add BIS and TEMED to i...

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Abstract

The invention discloses a coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and a preparation method thereof. The method comprises the following steps: soaking the stent into a dopamine and lysine solution to bath; soaking in an N-(3-aminopropyl) methylacrylate solution to carry out pre-treatment, and then dissolving the processed stent into a 2-methacryloyloxyethyl phosphorylcholine solution; adding tetramethylethylenediamine, N,N-methylene diacrylamine and ammonium persulfate to the solution to react; soaking into an arginine-glycine-aspartic acid (RGD) peptide solution, adding tetramethylethylenediamine (TEMED) and ammonium persulfate (APS) to react, so as to prepare a coating. Protein adsorption, denaturation of adsorption protein and platelet adhesiveness can be reduced and inhibited by a 2-methacryloyloxyethyl phosphorylcholine (MPC) part contained in the coating of the coronary stent, inflammatory response is inhibited, adhesion to the stent caused by vascular endothelial cells can be accelerated by the contained RGD part, the coronary stent has good biocompatibility, the stent better exists inside a body to play the function, and the coronary stent has good application prospect in the aspect of cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention discloses a coronary artery stent capable of anticoagulation and promoting adhesion of vascular endothelial cells and a preparation method thereof. Background technique [0002] Coronary artery stents have developed rapidly since they were used clinically, and have been used more and more. At present, they have become the main means of myocardial revascularization. In the cardiac cath labs of many hospitals, coronary stents are implanted in 80% of cases during percutaneous coronary intervention. The reasons are: (1) The angiographic image after implantation of the stent is very good, and the results in the acute phase are good; (2) Since the stent can treat acute or near occlusion caused by balloon expansion, the safety of interventional therapy is significantly improved; (3) ) stents can reduce the rate of restenosis and improve the long-term prognosis of patients; (4) the implantation of stents is easy to operate; (5) the application o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/04A61L31/02A61L31/10A61L31/16
Inventor 王思颖杨贤金亓洪昭崔振铎原续波张志刚
Owner TIANJIN UNIV
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