Granules of iron-based montmorillonite and preparation method thereof

A technology of iron-based montmorillonite and granules, which is applied in the field of pharmaceutical preparations of iron-based montmorillonite, and achieves the effect of good market prospect and improvement of anti-oxidative stability

Inactive Publication Date: 2014-08-27
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In view of the obvious advantages of the above-mentioned iron-based montmorillonite in the treatment of chronic renal failure and iron deficiency anemia, it is found through searching that the iron-based montmorillonite granule has not yet been developed, and the present invention is aimed at the further development of the iron-based montmorillonite Provide a method to realize the medicinal value of iron-based montmorillonite

Method used

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  • Granules of iron-based montmorillonite and preparation method thereof
  • Granules of iron-based montmorillonite and preparation method thereof
  • Granules of iron-based montmorillonite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation formula of the present invention is made up of following components:

[0036]

[0037] Make 1000 bags, each bag is 10g, each bag contains 0.225g of ferrous ion

[0038] The weight percent of iron ion in the described iron-based montmorillonite powder is 5%

[0039] (1) soft material: take 295g pregelatinized starch, add 4500ml70% ethanol and stir to mix evenly, be mixed with pregelatinized starch slurry; then take 4500g iron-based montmorillonite powder, add 5000g fructose, 200g aspartame And 3.0g of vitamin C, 1.0g of xylitol, and 1.0g of glucosinolate were mixed evenly, and then pregelatinized starch slurry was added and stirred evenly to make a soft material;

[0040] (2) Granulation: adopt extrusion granulation method, the soft material prepared in step (1) is crossed 20 mesh sieves with mechanical extrusion method to obtain wet granules;

[0041] (3) Drying: place the wet granules prepared in step (2) in a vacuum oven at 50°C to dry;

[0042] ...

Embodiment 2

[0044] The preparation formula of the present invention is made up of following components:

[0045]

[0046] Made into 1000 bags, each bag is 10g, each bag contains 0.315g of ferrous ion

[0047] The weight percent of iron ion in the described iron-based montmorillonite powder is 7%

[0048] (1) soft material: take 295g pregelatinized starch, add 4500ml70% ethanol and stir to mix evenly, be mixed with pregelatinized starch slurry; then take 4500g iron-based montmorillonite powder, add 5000g fructose, 200g aspartame And 3.0g of vitamin C, 1.0g of xylitol, and 1.0g of glucosinolate were mixed evenly, and then pregelatinized starch slurry was added and stirred evenly to make a soft material;

[0049](2) granulation: adopt extrusion granulation method, the soft material prepared in step (1) is crossed 24 mesh sieves with mechanical extrusion method and makes wet granule;

[0050] (3) Drying: place the wet granules prepared in step (2) in a vacuum oven at 55°C;

[0051] (4) ...

Embodiment 3

[0053] The preparation formula of the present invention is made up of following components:

[0054]

[0055] Make 1000 bags, each bag is 10g, each bag contains 0.270g of ferrous ion

[0056] The weight percent of iron ion in the described iron-based montmorillonite powder is 6%

[0057] (1) soft material: take 295g pregelatinized starch, add 4500ml70% ethanol and stir to mix evenly, be mixed with pregelatinized starch slurry; then take 4500g iron-based montmorillonite powder, add 5000g fructose, 200g aspartame And 3.0g of vitamin C, 1.0g of xylitol, and 1.0g of glucosinolate were mixed evenly, and then pregelatinized starch slurry was added and stirred evenly to make a soft material;

[0058] (2) Granulation: adopt extrusion granulation method, the soft material prepared in step (1) is crossed 20 mesh sieves with mechanical extrusion method to obtain wet granules;

[0059] (3) Drying: place the wet granules prepared in step (2) in a vacuum oven at 60°C to dry;

[0060] ...

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Abstract

The invention discloses granules for iron-based montmorillonite and a preparation method thereof, and relates to a medicinal preparation of iron-based montmorillonite. The granules consist of iron-based montmorillonite and pharmaceutically-acceptable auxiliary materials, wherein the auxiliary materials mainly comprise a filler, a bonding agent and a flavoring agent, and an antioxidant is added for resisting oxidization. The preparation is technically characterized by being prepared by the following steps: mixing pretreated iron-based montmorillonite with the filler, the bonding agent, the flavoring agent and the antioxidant according to a certain proportion; preparing the mixture into granules by means of wet granulation. The granules are used for treating chronic renal failure hyperphosphatemia and iron-deficiency anemia, and have the advantages of stable property, convenience in taking, no moisture absorption, softening, blocking or deliquescence, and the like.

Description

technical field [0001] The invention relates to a pharmaceutical preparation of iron-based montmorillonite, in particular to iron-based montmorillonite granules and a preparation process thereof, and belongs to the technical field of medicines. Background technique [0002] In recent years, the incidence of chronic kidney disease (CKD) has been increasing day by day, reaching about 10% in my country. Hyperphosphatemia is a common complication of chronic kidney disease, an important factor causing secondary hyperparathyroidism, changes in calcium and phosphorus deposition, vitamin D metabolism disorders, renal bone disease, and coronary artery, heart valve calcification, etc. Severe cardiovascular complications are closely related. [0003] Western medicine research on chronic renal failure began in 1840 and has a history of 160 years. The goal of western medicine treatment of chronic renal failure is relatively clear. The main purpose of non-dialysis therapy is to protect ...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K9/16A61K47/26A61K47/22A61P13/12A61P3/12A61P7/06
Inventor 乔敏刘钢李红新秦大伟牛夏邵兰兰孟震晓
Owner SHANDONG SBOND PHARMA
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