Method for preparing 2-taurine

Abstract

The invention discloses a method for preparing 2-taurine. The method comprises the following steps: reacting ethylene oxide with sodium hydrogen sulfite at 0.05-0.1MPa, pH value of 6.5-7.5 and temperature of 75-85 DEG C to prepare sodium hydroxyethyl sulfonate; performing ammonolysis reaction on the sodium hydroxyethyl sulfonate and liquid ammonia at 14-24 MPa and 160-280 DEG C to obtain an ammonolysis solution containing 2-taurine sodium, evaporating the ammonolysis solution to remove ammonia, neutralizing by using sulfuric acid, concentrating, crystallizing and separating, pre-drying in a boiling drying device or a vibration fluidized drying device, and then adding the dried product in a microwave drying device to dry and sterilize to obtain the 2-taurine, wherein the water content of the dry 2-taurine is reduced to be less than 0.05% in combination of the pre-drying of the boiling drying device or the vibration fluidized drying device and the far infrared of the microwave drying, and further the effect of sterilizing is achieved. The method disclosed by the invention is short in preparation time of the 2-taurine, high in yield, low in cost and easy for industrial production.

Description

technical field [0001] The invention relates to the field of manufacturing western medicine products, in particular to a method for preparing 2-aminoethanesulfonic acid. Background technique [0002] 2-aminoethanesulfonic acid, the pure product is colorless or white oblique crystal, odorless, stable chemical properties, soluble in organic solvents such as ether, because it was first extracted from ox bile in 1843, it was named "Taurine ". The biggest difference between it and other basic amino acids such as glutamic acid, lysine, methionine, alanine, serine, valine and threonine is that 2-aminoethanesulfonic acid does not directly participate in the synthesis of proteins, but A special amino acid that is released outside the cell. It is now known that 2-aminoethanesulfonic acid plays a variety of roles in the body, including detoxification, enhancing the stability of cell membranes, regulating (brain) production of excitatory neurotransmitters, and intercellular calcium le...

AI Technical Summary

Problems solved by technology

Its disadvantages are: because the esterification and sulfonation (reduction) reactions of this method are all reversible reactions, the interaction of reaction conditions, time, degree of reaction, and separation method causes the yield of 2-aminoethanesulfonic acid to be only 48%. ~52%, while the cost yield is 49%, high production cost, high energy consumption, high labor intensity

There has been no good technical solution to this drawback