Method for preparing 2-taurine

A technology of taurine sulfonic acid and sodium taurine sulfonate, which is applied to the preparation of sulfonic acid, chemical instruments and methods, and the preparation of organic compounds, can solve the problems of lack of good technical solutions, high labor intensity, and high production costs, and achieve The effect of low cost, energy saving, and small demand

Inactive Publication Date: 2014-09-03
王代龙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its disadvantages are: because the esterification and sulfonation (reduction) reactions of this method are all reversible reactions, the interaction of reaction conditions, time, degree of reaction, and separation metho...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation of sodium isethionate: react 1:1.1 molar ratio of ethylene oxide and sodium bisulfite at 0.05MPa, pH 6.5-7.5 and 85°C for 1.2 hours to prepare sodium isethionate .

[0018] Preparation of sodium 2-aminoethanesulfonate: in the presence of catalyst sodium carbonate and sodium bicarbonate (the molar ratio of sodium carbonate and sodium bicarbonate is 4:1) (the amount of catalyst is the mass of sodium isethionate 4%), sodium isethionate and liquid ammonia (the concentration of ammonia in the reaction solution is 25%, percent by weight) at 19MPa and 220°C for 28 minutes to obtain ammonia containing 2-aminoethanesulfonate Solution.

[0019] Preparation of 2-aminoethanesulfonic acid: After evaporating the ammonium solution containing 2-aminoethanesulfonic acid sodium to remove ammonia, neutralize it with 98% sulfuric acid at 30-70°C to a pH value of 7.8-7.9, then concentrate, Crystallize and separate to obtain 2-aminoethanesulfonic acid wet product with a water c...

Embodiment 2

[0022] Preparation of sodium isethionate: react 1:1.1 molar ratio of ethylene oxide and sodium bisulfite at 0.12MPa, pH 6.5-7.5 and 85°C for 1 hour to prepare sodium isethionate .

[0023] Preparation of sodium 2-aminoethanesulfonate: in the presence of catalyst sodium carbonate and sodium bicarbonate (the molar ratio of sodium carbonate and sodium bicarbonate is 6:1) (the amount of catalyst is the mass of sodium isethionate 5%), sodium isethionate and liquid ammonia (the concentration of ammonia in the reaction solution is 25%, percent by weight) at 20MPa and 260°C for 30 minutes to obtain ammonia containing 2-aminoethanesulfonate Solution.

[0024] Preparation of 2-aminoethanesulfonic acid: After evaporating the ammonium solution containing 2-aminoethanesulfonic acid to remove ammonia, neutralize it with 98% sulfuric acid at 30-70°C to a pH value of 7.8-7.9, then concentrate, Crystallize and separate to obtain 2-aminoethanesulfonic acid wet product with a water content of ...

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Abstract

The invention discloses a method for preparing 2-taurine. The method comprises the following steps: reacting ethylene oxide with sodium hydrogen sulfite at 0.05-0.1MPa, pH value of 6.5-7.5 and temperature of 75-85 DEG C to prepare sodium hydroxyethyl sulfonate; performing ammonolysis reaction on the sodium hydroxyethyl sulfonate and liquid ammonia at 14-24 MPa and 160-280 DEG C to obtain an ammonolysis solution containing 2-taurine sodium, evaporating the ammonolysis solution to remove ammonia, neutralizing by using sulfuric acid, concentrating, crystallizing and separating, pre-drying in a boiling drying device or a vibration fluidized drying device, and then adding the dried product in a microwave drying device to dry and sterilize to obtain the 2-taurine, wherein the water content of the dry 2-taurine is reduced to be less than 0.05% in combination of the pre-drying of the boiling drying device or the vibration fluidized drying device and the far infrared of the microwave drying, and further the effect of sterilizing is achieved. The method disclosed by the invention is short in preparation time of the 2-taurine, high in yield, low in cost and easy for industrial production.

Description

technical field [0001] The invention relates to the field of manufacturing western medicine products, in particular to a method for preparing 2-aminoethanesulfonic acid. Background technique [0002] 2-aminoethanesulfonic acid, the pure product is colorless or white oblique crystal, odorless, stable chemical properties, soluble in organic solvents such as ether, because it was first extracted from ox bile in 1843, it was named "Taurine ". The biggest difference between it and other basic amino acids such as glutamic acid, lysine, methionine, alanine, serine, valine and threonine is that 2-aminoethanesulfonic acid does not directly participate in the synthesis of proteins, but A special amino acid that is released outside the cell. It is now known that 2-aminoethanesulfonic acid plays a variety of roles in the body, including detoxification, enhancing the stability of cell membranes, regulating (brain) production of excitatory neurotransmitters, and intercellular calcium le...

Claims

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Application Information

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IPC IPC(8): C07C303/22C07C303/44C07C309/14
Inventor 王代龙陆韬
Owner 王代龙
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