Gold film microelectrode array and its manufacturing method

A micro-electrode array and micro-electrode technology, which are applied in the fields of electrochemical variables of materials, material analysis by electromagnetic means, and measurement devices, can solve problems such as inflammability and explosion, and achieve low cost, controllable size, and simple and easy operation. row effect

Inactive Publication Date: 2017-02-01
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, the method of preparing microelectrode arrays based on the assembly method mainly uses the pyrolysis of hydrocarbon gas with high carbon content to prepare carbon-based microelectrodes and arrays. This method requires the use of high-temperature open flames, and there is a potential risk of flammability and explosion.

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  • Gold film microelectrode array and its manufacturing method
  • Gold film microelectrode array and its manufacturing method
  • Gold film microelectrode array and its manufacturing method

Examples

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Effect test

Embodiment 1

[0033] Embodiment 1, preparation gold film microelectrode

[0034] 1) Preparation of nano gold sol:

[0035] After heating 100mL of the aqueous solution of 0.1% mass percent concentration of chloroauric acid to boiling, add 2.5mL of the mass percent concentration of 1% sodium citrate aqueous solution, and reflux for 10min. Remove the heat source, and wait for the solution to cool to room temperature to obtain nano-gold sol, which should be stored at low temperature and protected from light.

[0036] 2) Preparation of support body:

[0037] The tip of a quartz capillary was made into a micron-sized tip with a butane lighter under open flame conditions, and the diameter of the micron-sized tip was 10 μm, which was used as the support for preparing the gold film electrode in the next step.

[0038] 3) Wet deposition of gold on the inner wall of the capillary:

[0039] Push 2mL of acetone and 1mL of deionized water into the support drawn in 2) in turn under the push of a micro-...

Embodiment 2

[0051] Embodiment 2, preparation gold film microelectrode

[0052] 1) Preparation of nano-gold sol: same as step 1) of Example 1, only the amount of aqueous solution of sodium citrate with a concentration of 1% by mass was replaced by 1 mL from 2.5 mL;

[0053] 2) Preparation of the support body: three quartz capillaries were twisted and drawn with a butane lighter under open flame conditions to form an array of three capillaries with a tip, the diameter of the tip was 50 μm, as the next step to prepare the gold film electrode support body.

[0054] 3) Wet deposition of gold on the inner wall of the capillary: under the push of a micro-syringe pump, push 2mL of acetone and 2mL of deionized water into the support drawn in 2) in sequence for cleaning, and the cleaning flow rate is 20 μL / min;

[0055] Then the H with a volume ratio of 7:3 2 SO 4 :H 2 o 2 The composed piranha solution was pushed into the inner wall of the capillary by negative pressure at a flow rate of 15 μL...

Embodiment 3

[0062] Embodiment 3, preparation gold film microelectrode

[0063] 1) the preparation of nano-gold sol: according to embodiment 1 step 1), only the aqueous solution of the chloroauric acid of 0.1% is replaced by the aqueous solution of the chloroauric acid of 0.05% by mass percent concentration, and 2.5mL mass percent concentration is 1% aqueous solution of sodium citrate was replaced by 2 mL of 0.6% aqueous solution of sodium citrate;

[0064] 2) Preparation of support body: same as step 2) of Example 1;

[0065] 3) Wet deposition of gold on the inner wall of the capillary:

[0066] Push 2mL of acetone and 2.5mL of deionized water into the support drawn in 2) in sequence under the push of a micro-syringe pump for cleaning, and the cleaning flow rate is 15 μL / min;

[0067] Then the H with a volume ratio of 7:3 2 SO 4 :H 2 o 2 The composed piranha solution was pushed into the inner wall of the capillary by negative pressure at a flow rate of 10 μL / min for surface hydroxyl...

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Abstract

The invention discloses a gold film microelectrode array, a microelectrode array and a manufacture method of the microelectrode array. The method comprises the steps of self-assembling amino silane on the inner wall of a hydroxylated capillary, assembling single-layer gold sol nano particles under the static action of amidogen and nanogold, and slowly injecting chemical plating liquid containing chloroauric acid and hydroxylamine hydrochloride in the capillary to grow a gold thin film. Wet process deposition is adopted to prepare the gold film microelectrode and the microelectrode array, a heat source is not required, the operation is simple and easy, the size is controllable, the potential flammable and combustible risk of thermal cracking of a carbon source for preparation of the microelectrode array is avoided, and a continuous uniform gold layer with the controllable thickness can be formed on the inner wall of glass or the capillaries with different sizes and shapes. The single microelectrode and the electrode array containing three microelectrodes, prepared by adopting the method, can be potentially applied to the micro-zone analysis of chemical release on cell surfaces, and have important functions of knowing cell surface kinetics and deeply understanding cell surface physiological status, processes and mechanisms.

Description

technical field [0001] The invention belongs to the field of preparation of microelectrodes and microelectrode arrays, and relates to a gold film microelectrode array and a manufacturing method thereof. Background technique [0002] A microelectrode refers to an electrode whose one-dimensional size is a microelectrode (10 -6 m) to nanometer (10 -9 m) class of electrodes. When the one-dimensional size of the electrode is reduced from millimeters to microns, it exhibits many excellent electrochemical characteristics, such as extremely high steady-state current density, extremely short response time, small polarization current, small ohmic voltage drop, and With high mass velocity and high signal-to-noise ratio, it can be used for transient electrode process research, high-impedance electrolyte systems and flow systems. The microelectrode array is composed of multiple microelectrodes connected in parallel, which not only retains the excellent physical and electrochemical cha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/327
Inventor 林雨青徐亚男李琳黎琳波胡良璐陈箫
Owner CAPITAL NORMAL UNIVERSITY
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