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Preparation method for copper ion-polyphenol coordination compound chelate material with controllable nitrogen monoxide catalytic release function

A technology of nitric oxide and copper ions, which is applied in the directions of pharmaceutical formulations, dental preparations, packaging items, etc., can solve the problems of limited grafting amount, peeling off of the surface modification layer, and multi-step cumbersome grafting method, and achieves the preparation cost. Low, promotes bone formation, strengthens antibacterial effect

Active Publication Date: 2014-12-24
GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The multi-step of such grafting side is relatively loaded down with trivial details; And Cu 2+ It only exists in the surface layer of the modified material, and its grafting amount is limited, and with the degradation of the transition polymer layer, the surface Cu 2+ Easily peels off from the modified layer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of a chelate material having controllable nitrogen monoxide catalytic release of copper ions and polyphenol complexes, the steps of which are as follows:

[0020] A. Dissolve Dopamine (Dopamine) with a concentration of 0.1mg / mL, copper chloride with a concentration of 1mg / mL and ferric chloride with a concentration of 0-10mg / mL in an aqueous solution of pH=2-14, and react at room temperature 6 hours

[0021] B. The reaction solution in step A is centrifuged, washed, dialyzed and freeze-dried to obtain the target Cu 2+ Chelate material with complexes with dopamine.

Embodiment 2

[0023] A preparation method of a chelate material having controllable nitrogen monoxide catalytic release of copper ions and polyphenol complexes, the steps of which are as follows:

[0024]A. Dissolve norepinephrine with a concentration of 1mg / mL, copper chloride with a concentration of 0.1mg / mL and ferric chloride with a concentration of 0-10mg / mL in an aqueous solution of pH=2-14, and react at room temperature 6 hours

[0025] B. The reaction solution in step A is centrifuged, washed, dialyzed and freeze-dried to obtain the target Cu 2 Chelate material with norepinephrine complexes.

Embodiment 3

[0027] A preparation method of a chelate material having controllable nitrogen monoxide catalytic release of copper ions and polyphenol complexes, the steps of which are as follows:

[0028] A. Dissolving tannic acid (TA) with a concentration of 0.1 mg / mL, copper chloride with a concentration of 1 mg / mL and ferric chloride with a concentration of 0-10 mg / mL in an aqueous solution of pH=2-14, at room temperature Reaction for 6 hours

[0029] B. The reaction solution in step A is centrifuged, washed, dialyzed and freeze-dried to obtain the target Cu 2+ With tannic acid (TA) complex material.

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PUM

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Abstract

The invention discloses a preparation method for a copper ion-polyphenol coordination compound chelate material with a controllable nitrogen monoxide catalytic release function. The preparation method comprises the step of carrying out centrifuging, cleaning, dialyzing and freeze-drying on a reaction solution in a mixed aqueous solution composed of soluble metal salts, soluble copper salts and a compound with an o-phenol structure to obtain the copper ion-polyphenol coordination compound chelate material with a nitrogen monoxide catalytic function. The copper ion-polyphenol coordination compound chelate material obtained by the method disclosed by the invention is excellent in biocompatibility and antimicrobial property, and has the function of inducing and catalyzing release of endogenous nitrogen monoxide in a blood environment. The copper ion-polyphenol coordination compound chelate material can be widely used as a filling material for a controlled release system.

Description

technical field [0001] The invention relates to a method for preparing a chelate coating or material of copper ions and polyphenol complexes with controllable catalytic rate of nitric oxide. Background technique [0002] Divalent copper ions (Cu 2+ ) is a component of many metalloenzymes (diamine oxidase, cytochrome C oxidase, etc.) in the human body, and is an essential trace element for the human body; Cu 2+ The lack of it may even lead to embryonic hypoplasia, connective tissue defects and other diseases. Cu 2+ It has been proved to have significant antibacterial function; at the same time Cu 2+ It also has the ability to promote the formation of callus at the fracture site and inhibit the mineral tissue absorption process of the bone resorption pit on the dental grinding sheet; in addition, Cu 2+ / Cu + It also has a strong oxidation catalytic function, including nitric oxide (NO) catalytic function, that is, it can catalyze the continuous synthesis of NO donors in t...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/54A61L31/04A61L33/02A61K6/02A61K6/00
Inventor 黄楠杨志禄王进齐鹏凯涂秋芬杨莹熊开琴翁亚军李龙李亚龙
Owner GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD