Unlock instant, AI-driven research and patent intelligence for your innovation.

High strength multistage micro-nano structural silicon-based bone repair scaffold material and preparation method and application thereof

A scaffold material and bone repair technology, applied in the fields of materials science and medicine, can solve problems such as high brittleness, elevated pH of the system, and poor plasticity

Inactive Publication Date: 2015-02-25
EAST CHINA UNIV OF SCI & TECH
View PDF5 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the characteristics of the material itself, the multi-level scaffold materials with micro-macropores and mesoporous structures have significant defects in the following aspects: ① high brittleness, poor biomechanical properties, ② difficult molding, poor plasticity, ③ rapid material degradation, Cause the pH of the system to increase[Microporous. Mesoporous Materials143(2011)311-319, Acta Biomaterialia7(2011)2644-2650]
[0004] At present, there are three common methods for preparing porous scaffolds: ① hard template method: NaCl particles, PMMA / PS microspheres, the inability to obtain ideally connected macropores is the key problem that limits its application; ② 3D printing technology, which can precisely control the macroporous structure and morphology, but a certain proportion of polymer additives must be compounded during the molding process, which affects its mesoporous structure and biological properties to a certain extent. ③Polyurethane foam method, although the process is economical and easy to operate and can obtain a porous structure with high interconnected porosity, However, the scaffolds prepared by multiple dipping-extrusion-heat treatment have poor mechanical properties and poor pore uniformity, which directly affects their use effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High strength multistage micro-nano structural silicon-based bone repair scaffold material and preparation method and application thereof
  • High strength multistage micro-nano structural silicon-based bone repair scaffold material and preparation method and application thereof
  • High strength multistage micro-nano structural silicon-based bone repair scaffold material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] The present invention also provides the preparation method of the silicon-based bone repair scaffold material with micro-nano hierarchical porous structure, comprising: 100 parts by weight of mesoporous silicon-based xerogel material and 5-40 parts by weight of mesoporous silicon oxide microspheres Mix parts by weight; mix the mixture of mesoporous silicon-based xerogel material and mesoporous silica microspheres at 0.3-0.8g / 1cm 3 The mass-to-volume ratio is poured on polyurethane sponge, aged, dried, and calcined to obtain the scaffold material.

[0045] Among them, a series of parameters such as different enhancer content, different types of enhancer, polyurethane foam density and sol viscosity can be adjusted to prepare bone repair composite scaffolds with different mechanical strengths; at the same time, the synthesis conditions (such as: solvent, pH, template agent, temperature) can prepare a variety of mesoporous materials with different specific surface areas and...

Embodiment 1

[0068] Example 1, Preparation of Mesoporous Silicon Microsphere Reinforcing Agent 1

[0069] Weigh 4.8g P123 and add 120mL H 2 O and 20mL of concentrated hydrochloric acid (12mol / L). Stir vigorously until the surfactant (P123) is completely dissolved until transparent, then add 3.75g of calcium nitrate tetrahydrate, 0.62g of triethyl phosphate and 7.42g of ethyl orthosilicate. Stir at 35°C for 24h. Mesoporous silicon microsphere reinforcing agent 1 was obtained.

[0070] If the prepared material is dried and sintered, the average mesopore diameter of the powder can be measured as: 3.5nm, and the BET calculation result shows that the specific surface area of ​​the material is 829m 2 / g.

Embodiment 2

[0071] Example 2, Preparation of Mesoporous Silicon Microsphere Reinforcing Agent 2

[0072] Weigh 4.8g P123 and add 120mL H 2 O and 20mL of concentrated hydrochloric acid (12mol / L). Stir vigorously until the surfactant (P123) is completely dissolved, then add 3.75g of calcium nitrate tetrahydrate, 0.62g of triethyl phosphate and 7.42g of ethyl orthosilicate. Stir at 35°C for 24h, then hydrothermally treat at 100°C for 24h. Mesoporous silicon microsphere reinforcing agent 2 was obtained.

[0073] If the prepared material is dried and sintered, the average mesopore diameter of the powder can be measured as: 8.2nm, and the BET calculation result shows that the specific surface area of ​​the material is 781m 2 / g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Specific surface areaaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Average mesopore diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a high strength multistage micro-nano structural silicon-based bone repair scaffold material and a preparation method and application thereof, the multistage structural scaffold material with excellent mechanical properties is prepared from mesoporous silica based xerogel as a substrate by adding a mesoporous silica microsphere reinforcing agent, the prepared silicon-based bone repair scaffold material has highly-connected 200-500 mum micro scale macropores and 2-22nm nano mesoporous, the porosity is up to 60-90%, and the mechanical properties can reach up to 10MPa. The multistage micro-nano structural silicon-based bone repair scaffold material can be used as bone tissue engineering scaffolds and drug controlled release carriers and the like.

Description

technical field [0001] The invention belongs to the field of material science and medicine; more specifically, the invention relates to a silicon-based composite bone repair scaffold material with high mechanical strength and multi-level structure, its preparation method and application. Background technique [0002] Diseases, trauma, population aging and natural disasters can all lead to damage to human bone tissue, and there is a huge demand for bone repair materials in clinical practice. However, autologous bone grafting, which is the golden rule, is far from being able to meet the status quo due to its limited source and the pain of secondary surgery for patients. Allograft bone transplantation also has biological safety hazards, which may leave patients with lifelong immune rejection and bring unknown diseases. Therefore, artificial preparation of bone repair materials has received more and more attention clinically. [0003] Silicon-based materials, such as bioactive...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/56A61L27/10A61L27/02A61L27/54A61L27/50
CPCC12M25/14
Inventor 刘昌胜袁媛唐为林丹牛浩一
Owner EAST CHINA UNIV OF SCI & TECH