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A kind of high-strength and high-elastic vascular stent and preparation method thereof

A vascular stent and high-elasticity technology, applied in the field of high-strength and high-elastic vascular stent and its preparation, to achieve the effect of excellent vascular performance, mechanical properties and uniform appearance

Active Publication Date: 2016-02-17
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the shortcomings of the existing artificial vascular stents, the present invention proposes a method for preparing high-strength and high-elastic vascular stents by electrospinning. Through the compounding of two polymers, using electrospinning technology combined with soaking removal method, the invention succeeds A non-toxic artificial vascular scaffold with high strength, high elasticity and high porosity has been prepared, which is expected to be applied in clinical use

Method used

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  • A kind of high-strength and high-elastic vascular stent and preparation method thereof
  • A kind of high-strength and high-elastic vascular stent and preparation method thereof
  • A kind of high-strength and high-elastic vascular stent and preparation method thereof

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Embodiment 1

[0031] Pure polyurethane (PU, C 28 h 44 N 2 o 11 ), pure polylactic acid (PLA, (C 6 h 8 o 4 ) n ) and the mixture of the two are respectively dissolved in a mixed solvent (the mass ratio of acetone and N,N-dimethylformamide in the mixed solvent w / w=1:1), and prepared into three different proportions of 8wt% to 15wt% concentration A kind of spinning solution, as a precursor solution; the precursor solution is placed in a syringe pump equipped with a needle with a diameter of 0.5-0.9mm, and a voltage of 8-15kV is applied to carry out electrospinning when the working distance is 20cm, and it is received by aluminum foil Fibers can be used to obtain fiber membranes with different mechanical properties. After performance comparison, the fiber membrane with excellent mechanical properties and high porosity is polyurethane / polylactic acid composite fiber membrane. Therefore, the precursor solution is prepared by dissolving polyurethane / polylactic acid composite in a mixed solv...

Embodiment 2

[0034] Pure polycaprolactone (PCL, (C 6 h 10 o 2 ) n ), polylactic acid (PLA, (C 6 h 8 o 4 ) n ) and the mixture of the two are dissolved in a mixed solvent in which the mass ratio of acetone and N,N-dimethylformamide w / w=1:5 in the mixed solvent is formulated to be 8%-10% concentration by mass percentage Three kinds of spinning solutions in different proportions, that is, the precursor solution; the precursor solution is placed in a syringe pump equipped with a needle with a diameter of 0.2mm, and a voltage of 10-15kV is applied to carry out electrospinning when the working distance is 25cm. The aluminum foil receives the fiber, and the fiber membrane with different mechanical properties can be obtained. After comparison, the precursor solution with excellent mechanical properties and high porosity was obtained as the electrospinning solution of polymer B—PCL+PLA composite electrospinning solution.

[0035] Dissolve dextran in water to make an electrospinning solution...

Embodiment 3

[0037] Pure polycaprolactone (PCL, (C 6 h 10 o 2 ) n ), polylactic acid-glycolic acid copolymer (PLGA, 75:25) and the mixture of the two are respectively dissolved in the mixed solvent, and in the mixed solvent, acetone and N, N-dimethylformamide mass percentage w / w =1:4, prepared into electrospinning solutions with different concentrations of 8%-10% by mass; put the precursor solution in a syringe pump equipped with a needle with a diameter of 0.5-1.0mm, and apply a voltage of 10-25kV at the working distance Electrospinning is carried out when the diameter is 20 cm, and fiber membranes with different mechanical properties can be obtained by receiving fibers through aluminum foil, and finally the electrospinning solution of PCL+PLGA is selected.

[0038] Put polyvinylpyrrolidone (PVP, (C 6 h 9 NO) n ) was dissolved in ethanol to form an ethanol solution with a mass percentage of 9%, the electrospinning solution of polymer A was placed in a syringe pump equipped with a ne...

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Abstract

The invention discloses a high-strength high-elasticity intravascular stent and a preparation method thereof and belongs to the field of chemical and ecological engineering. The high-strength high-elasticity intravascular stent has the advantages that a biocompatible polymer material is taken as a precursor; firstly, an electrostatic spinning method is adopted for preparing fibrous membranes with different mechanical properties; and on this basis, an electrospinning technology and a solution soaking and removing method are combined for preparing a high-strength, high-elasticity and high-porosity artificial intravascular stent, fibers used for forming the artificial intravascular stent are smooth in surface, uniform in morphology, narrow in fiber diameter distribution range, and excellent in vascular performance. The obtained artificial intravascular stent with high cell compatibility, strength, elasticity and porosity can be produced in a large scale and is expected to be applied to the actual clinical diagnosis.

Description

technical field [0001] The invention belongs to a method for preparing a high-strength and high-elasticity artificial vascular stent in the field of chemical and biological engineering, and in particular relates to a high-strength and high-elasticity vascular stent and a preparation method thereof. Background technique [0002] In recent years, cardiovascular disease has a high incidence rate all over the world. At present, the main method for treating cardiovascular diseases is vascular transplantation, so the human demand for artificial vascular stents is increasing. An artificial vascular stent that can be used for transplantation needs to meet the following conditions: no bleeding when connected, certain strength and flexibility, stable physical and chemical properties, suitable porosity, and biocompatibility. However, mechanical properties are the most basic prerequisites for the use of vascular stents. So far, a series of methods and materials have been proposed to p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/06D01D5/00
Inventor 王女郭凤云赵勇江雷
Owner BEIHANG UNIV
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