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Preparation method and application of bionic temperature-sensitive molecular engram composite film

A technology of molecular imprinting and composite membrane, applied in chemical instruments and methods, membrane technology, ion exchange, etc., to achieve the effects of good thermal stability, high effective imprinting specific surface area, and fast adsorption kinetic properties

Inactive Publication Date: 2015-04-22
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction and separation methods of artemisinin are mainly steam distillation, organic solvent extraction, Soxhlet extraction, ultrasonic extraction, microwave-assisted extraction, supercritical fluid extraction, and the method of separation and purification of artemisinin by molecular imprinted composite membrane is rarely reported

Method used

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  • Preparation method and application of bionic temperature-sensitive molecular engram composite film
  • Preparation method and application of bionic temperature-sensitive molecular engram composite film
  • Preparation method and application of bionic temperature-sensitive molecular engram composite film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Self-assembled polymerized porous alumina ceramic film on the surface of dopamine

[0053] First, configure 10mM tris(hydroxymethyl)aminomethane hydrochloride (Tris-HCl) aqueous solution, then adjust the pH value to 8.5, and dissolve dopamine (2mg / L) in the above 10mM Tris-HCl (pH=8.5) solution. Then a porous alumina ceramic membrane (Al 2 o 3 ) placed in the above solution, 25 ° C dopamine self-assembly modification for 16 hours, so that the polydopamine layer deposited on the Al 2 o 3 After the reaction, the surface was fully cleaned with distilled water, and then the gained polydopamine modified membrane (PDAAl 2 o 3 ) and dry at room temperature for later use.

[0054] (2) PDAAl 2 o 3 Surface Initiated Atom Transfer Radical Polymerization (ATRP) to Prepare Thermosensitive Imprinted Composite Membranes (TMICMs)

[0055] First, add 1 mL of bromoisobutyryl bromide (2-BIB) to 15 mL of refined tetrahydrofuran, mix well and add to the dropping funnel for later...

Embodiment 2

[0067] (1) Self-assembled polymerized porous alumina ceramic film on the surface of dopamine

[0068] First, configure 10mM tris(hydroxymethyl)aminomethane hydrochloride (Tris-HCl) aqueous solution, then adjust the pH value to 8.5, and dissolve dopamine (2mg / L) in the above 10mM Tris-HCl (pH=8.5) solution. Then a porous alumina ceramic membrane (Al 2 o 3 ) placed in the above solution, 25 ° C dopamine self-assembly modification for 16 hours, so that the polydopamine layer deposited on the Al 2 o 3 After the reaction, the surface was fully cleaned with distilled water, and then the gained polydopamine modified membrane (PDAAl 2 o3 ) and dry at room temperature for later use.

[0069] (2) PDAAl 2 o 3 Surface Initiated Atom Transfer Radical Polymerization (ATRP) to Prepare Thermosensitive Imprinted Composite Membranes (TMICMs)

[0070] First, add 1 mL of bromoisobutyryl bromide (2-BIB) to 15 mL of refined tetrahydrofuran, mix well and add to the dropping funnel for later u...

Embodiment 3

[0082] (1) Self-assembled polymerized porous alumina ceramic film on the surface of dopamine

[0083] First, configure 10mM tris(hydroxymethyl)aminomethane hydrochloride (Tris-HCl) aqueous solution, then adjust the pH value to 8.5, and dissolve dopamine (2mg / L) in the above 10mM Tris-HCl (pH=8.5) solution. Then the porous alumina ceramic membrane (Al 2 o 3 ) placed in the above solution, 25 ° C dopamine self-assembly modification for 16 hours, so that the polydopamine layer deposited on the Al 2 o 3 After the reaction, the surface was fully cleaned with distilled water, and then the gained polydopamine modified membrane (PDAAl 2 o 3 ) and dry at room temperature for later use.

[0084] (2) PDAAl 2 o 3 Surface Initiated Atom Transfer Radical Polymerization (ATRP) to Prepare Thermosensitive Imprinted Composite Membranes (TMICMs)

[0085] First, add 1mL of bromoisobutyryl bromide (2-BIB) to 15ml of refined tetrahydrofuran, mix well and add to the dropping funnel for later...

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Abstract

The invention relates to a preparation method of a bionic temperature-sensitive molecular engram composite film and belongs to the technical field of preparation of environmental materials. The preparation method particularly is a method for preparing the bionic temperature-sensitive molecular engram composite film by taking a porous aluminum oxide ceramic film as a substrate, artemisinin as a template molecule, acrylamide (AM) as a functional monomer, N-isopropyl acrylamide as a temperature-sensitive monomer and ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent, combining a dopamine biological bionic principle and combining dopamine self-assembly interfacial polymerization and atomic transfer free radical polymerization. By combining a static adsorption experiment with selective separation infiltration experiment, the adsorption equilibrium, dynamics performance and selective recognition separation performance of a prepared engram film are researched. Results show that the artemisinin engram film obtained by using the preparation method disclosed by the invention has relatively high adsorptivity, superior artemisinin molecular recognition permeability, and excellent environmental response type (temperature-sensitive switch) selective separation performance.

Description

technical field [0001] The invention belongs to the technical field of material preparation, and relates to the preparation and separation application of a bionic temperature-sensitive molecular imprinted composite membrane. Background technique [0002] Dopamine is a common neurotransmitter, and its electrochemical behavior has been extensively studied by researchers. At the same time, the dopamine solution can react with a series of solid substrates to form a polydopamine film on the surface. Dopamine can polymerize and attach to a wide variety of inorganic and organic surfaces via robust covalent and noncovalent interactions. The catechol group of dopamine is oxidized to form a compound with catechol. The anti-disproportionation reaction between dopamine and dopamine quinone generates semiquinone free radicals, which are then coupled into cross-linked bonds, and a tightly adhered cross-linked composite layer is formed on the surface of the collective material. Dopamine...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F220/54C08F220/56C08K9/04C08K3/22C08J9/26B01D71/02B01D69/12B01D67/00B01J20/26B01J20/30B01D15/08B01D61/00
Inventor 吴易霖严铭李春香刘馨林吕鹏霍鹏伟闫永胜
Owner JIANGSU UNIV
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