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A preparation method of grafted cellulose medicinal molecules with ph/temperature responsiveness

A temperature-responsive, cellulose technology, applied in the fields of polymer materials and biomedical engineering, can solve the problems of difficult separation of grafted cellulose molecules, strong volatility, environmental pollution, etc., and achieve shortened time and controllable reaction process. , the effect of improving the catalytic efficiency

Inactive Publication Date: 2017-07-14
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the solvent systems for modifying natural cellulose raw materials mainly include organic solvent systems such as copper ammonia solution, N-methylmorpholine-N-oxide and lithium chloride / dimethylacetamide. These organic solvents are flammable and toxic. Strong volatility, difficult to completely separate from grafted cellulose molecules, easy to cause environmental pollution

Method used

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  • A preparation method of grafted cellulose medicinal molecules with ph/temperature responsiveness
  • A preparation method of grafted cellulose medicinal molecules with ph/temperature responsiveness
  • A preparation method of grafted cellulose medicinal molecules with ph/temperature responsiveness

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Embodiment 1

[0032] 1. Synthesis of cellulose macroinitiator MCC-BiB

[0033] Add 0.509 g of microcrystalline cellulose and 10.075 g of [AMIM]Cl into a 100 mL three-neck flask, pass N 2 Protected, magnetically stirred for 1 h in an oil bath at 80 °C to ensure that the microcrystalline cellulose was completely dissolved, and then cooled to obtain a light brown transparent solution with a MCC / [AMIM]Cl (mass ratio) of about 5%. Add 8mL of 2-bromoisobutyryl bromide dropwise at room temperature, stir for 0.5h, react for 24h at room temperature, pour it into a 500mL beaker, add excess distilled water to it, precipitate a white precipitate, suction filter, and repeat After washing 3 times, the product was freeze-dried to obtain the macromolecular initiator MCC-BiB, and the grafting efficiency of the obtained macromolecular initiator could reach 97%.

[0034] 2. Synthesis of pH-sensitive cellulose graft copolymer MCC-g-PDEAEMA

[0035] Accurately weigh 0.050g of macromolecular initiator MCC-BiB ...

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Abstract

The invention belongs to the field of high polymer materials and biomedical engineering, and particularly relates to a method for preparing a grafted cellulose medicinal molecule with pH / temperature responsiveness by modifying cellulose raw materials via an atom transfer radical polymerization (ATRP) technology in an ionic liquid homogeneous system. The method comprises the following steps: by taking ionic liquid as a solvent and taking microcrystalline cellulose as a raw material, dissolving the microcrystalline cellulose in the ionic liquid 1-allyl-3-methylimidazolium chloride ([AMIM] C1); preparing a macroinitiator MCC-BiB by 2-bromopropionyl bromide; importing a micromolecular alcohol cosolvent to ensure that a homogeneous reaction system is formed by a pH / temperature sensitive monomer and the ionic liquid; grafting the functional monomer onto the microcrystalline cellulose by utilizing an ATRP method to form a grafted cellulose molecular brush, wherein the grafting efficiency can be up to 80%, the reaction is controllable and the molecular weight distribution is 1.25. The prepared cellulose grafted copolymer can be self-assembled into spherical micelle in DME, has certain pH and temperature sensitivity and can be used as a drug sustained release carrier.

Description

technical field [0001] The invention relates to a method for modifying microcrystalline cellulose, which belongs to the fields of polymer materials and biomedical engineering. Specifically, it is a method for modifying microcrystalline cellulose by using atom transfer radical polymerization (ATRP) technology. Environmentally sensitive functional monomers such as pH / temperature are grafted onto microcrystalline cellulose molecules, and small molecule alcohol co-solvents are introduced into the reaction to form a homogeneous system to prepare grafted fibers with pH / temperature characteristics and uniform molecular weight distribution Pharmaceutical polymer materials. Background technique [0002] In recent years, functional polymer materials, as carriers of drugs, gene delivery and controlled release, have been widely used in biotechnology, and have gradually become a new type of main controlled release carrier material. As a natural biomacromolecule that exists widely in na...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/02C08F220/34C08F220/54C08F220/06A61K47/38
CPCY02P20/54
Inventor 唐二军杜凯迪袁淼
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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