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Magnesium alloy containing cell response anticorrosion coating as well as preparation method and application thereof

A corrosion-resistant coating, magnesium alloy technology, used in coatings, prostheses, medical science, etc., can solve the problems of no biological activity, rough coating, cracks, etc., to promote adhesion and growth, good corrosion Protective effect, the effect of solving poor corrosion resistance

Inactive Publication Date: 2015-05-06
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the coatings formed by plasma anodization are mostly rough, porous, cracked surfaces, and are not biologically active.

Method used

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  • Magnesium alloy containing cell response anticorrosion coating as well as preparation method and application thereof
  • Magnesium alloy containing cell response anticorrosion coating as well as preparation method and application thereof
  • Magnesium alloy containing cell response anticorrosion coating as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A magnesium alloy containing a cell-responsive corrosion-resistant coating is prepared as follows:

[0032] (1) Substrate pretreatment

[0033] Polish the magnesium alloy sheet with 100-mesh, 300-mesh and 2000-mesh sandpaper in turn until the surface is bright, and then ultrasonically clean it with acetone for 5 minutes to obtain a clean metal surface;

[0034] (2) Plasma anodizing

[0035] With 15g / L Na 2 SiO 3 and 3g / L KOH solution as the electrolyte, the magnesium alloy sheet processed in step (1) is the anode, and the graphite is the cathode, the magnesium alloy sheet and the graphite rod are immersed in the electrolyte, and the voltage is 350V, the frequency is 100Hz, and the duty cycle A DC pulse power supply with a ratio of 30% and a distance between Yin and Yang of 4 cm is used to perform plasma anodic oxidation treatment on magnesium alloy, and the treatment time is 10 minutes;

[0036] (3) Layer-by-layer self-assembly

[0037] Soak the magnesium alloy aft...

Embodiment 2

[0039] A magnesium alloy containing a cell-responsive corrosion-resistant coating is prepared as follows:

[0040] (1) Substrate pretreatment

[0041] With embodiment 1;

[0042] (2) Plasma anodizing

[0043] With 5g / L Na 2 SiO 3 And 1g / L KOH solution is the electrolyte, the magnesium alloy sheet after step (1) is the anode, and the graphite is the cathode. The magnesium alloy sheet and the graphite rod are immersed in the electrolyte, and the voltage is 200V, the frequency is 300Hz, and the duty cycle A DC pulse power supply with a ratio of 10% and a distance between Yin and Yang of 3 cm is used to perform plasma anodic oxidation treatment on magnesium alloy, and the treatment time is 20 minutes;

[0044] (3) Layer-by-layer self-assembly

[0045] Soak the magnesium alloy after step (2) in the 1mg / mL polyethyleneimine solution for 15 minutes, then wash it with ultrapure water for 1 minute, and spin-coat the 1mg / mL chitosan-acetic acid solution on the magnesium alloy surfa...

Embodiment 3

[0047] (1) Substrate pretreatment

[0048] With embodiment 1;

[0049] (2) Plasma anodizing

[0050]With 50g / L Na 2 SiO 3 And 5g / L KOH solution is electrolyte, the magnesium alloy sheet after step (1) is anode, and graphite is cathode, magnesium alloy sheet and graphite rod are immersed in electrolyte, adopting voltage is 500V, frequency is 500Hz, duty cycle A DC pulse power supply with a ratio of 50% and a distance between Yin and Yang of 6 cm is used to perform plasma anodic oxidation treatment on magnesium alloy, and the treatment time is 30 minutes;

[0051] (3) Layer-by-layer self-assembly

[0052] Soak the magnesium alloy after step (2) in the 10mg / mL polyethyleneimine solution for 7 minutes, then wash it with ultrapure water for 1 minute, and spin-coat the 10mg / mL chitosan-acetic acid solution on the magnesium alloy surface, After cleaning with ultrapure water, spin-coat 10 mg / mL sodium polystyrene sulfonate solution; wash once with ultra-pure water for each spin-c...

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Abstract

The invention discloses a magnesium alloy containing cell response anticorrosion coating as well as a preparation method and application thereof, wherein a cell response anticorrosion coating is arranged on the surface of the magnesium alloy, and is composed of a plasma anodization coating and a lamination structure; the lamination structure is formed by using chitosan-sodium polystyrene sulfonate as a repetitive unit to cover the plasma anodization coating. According to the invention, the magnesium alloy surface is coated through a plasma anodization technology, and the cell response anticorrosion coating is constructed on the magnesium alloy surface by combining with a layer-by-layer self-assembly technology, so that the corrosion resistance of a magnesium alloy base material is improved, and the adhesion and growth of osteoblasts on the material surface are promoted, thus, the requirements on magnesium alloy as an implanted material are satisfied, the problems of poor corrosion resistance and poor cell compatibility of magnesium alloy are solved effectively, the clinical application range of magnesium alloy is expanded, and the long-term effectiveness of clinical applications is improved.

Description

technical field [0001] The invention belongs to the field of medical metal materials, and in particular relates to a magnesium alloy containing a cell-responsive corrosion-resistant coating and a preparation method and application thereof. Background technique [0002] Medical magnesium alloy materials have excellent mechanical properties, will be gradually corroded and degraded in the human body, and finally absorbed and metabolized by the body, and have degradable ability in the physiological environment. Metal magnesium exists in bone tissue, and the mechanical properties of magnesium alloy and human bone are similar, such as elastic modulus. As an alternative material for hard tissue repair, magnesium alloy does not need to consider the toxicity of metal ion release and the problem of secondary surgery. It can solve the problems of insufficient strength and stiffness of current degradable polymer materials, and has important application value and broad application prospe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/30A61L27/40A61L27/34A61L27/04
Inventor 刘鹏赵永春
Owner CHONGQING UNIV
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